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Research Article

Construction of a prognostic model based on genome-wide methylation analysis of miRNAs for hepatocellular carcinoma

    Zhaoqi Shi‡

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    ‡Zhaoqi Shi and Xiaolong Liu contributed equally

    Search for more papers by this author

    ,
    Xiaolong Liu‡

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    ‡Zhaoqi Shi and Xiaolong Liu contributed equally

    Search for more papers by this author

    ,
    Duguang Li

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    ,
    Xiaoxiao Fan

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    ,
    Lifeng He

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    ,
    Daizhan Zhou

    **Author for correspondence: Tel.: +86 139 1702 1526;

    E-mail Address: 3416252@zju.edu.cn

    Life Science Research Center, The First Affiliated Hospital of Xinxiang Medical University, Weihui, 453100, Henan, China

    &
    Hui Lin

    *Author for correspondence: Tel.: +86 137 3805 5489;

    E-mail Address: 369369@zju.edu.cn

    Department of General Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, China

    Published Online:https://doi.org/10.2217/epi-2023-0365

    Aim: Using the methylation level of miRNA genes to develop a prognostic model for patients with hepatocellular carcinoma (HCC). Materials & methods: least absolute shrinkage and selection operator and multivariate Cox regression analyses were performed to develop a prognostic model. One miRNA in the model was selected for verification. Results: A prognostic model was developed using eight miRNAs. The areas under the curve for predicting overall survival at 1, 3 and 5 years were 0.75, 0.81 and 0.81. miR-223 was found to be hypomethylated in 160 HCC tissues, and its methylation level was associated with Barcelona Clinic Liver Cancer stages and the prognosis of patients with HCC. Conclusion: The prognostic model based on miRNA methylation levels has the capability to partially forecast the prognosis of patients with HCC.

    Tweetable abstract

    Our research has formulated a prognostic model using the methylation levels of eight miRNA genes for partially forecasting the overall survival rate of patients with hepatocellular carcinoma.

    Papers of special note have been highlighted as: • of interest

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