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SET protein as an epigenetics target

    Gabriel da Silva‡

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    ‡Both authors contributed equally

    Search for more papers by this author

    ,
    Thaís Moré Milan‡

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    ‡Both authors contributed equally

    Search for more papers by this author

    ,
    Pablo Shimaoka Chagas

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    ,
    Glauce Lunardelli Trevisan

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    ,
    Camila Lopes Ferraz

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    &
    Andréia Machado Leopoldino

    *Author for correspondence:

    E-mail Address: andreiaml@usp.br

    Department of Clinical Analyses, Toxicology & Food Sciences, School of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Brazil

    Published Online:https://doi.org/10.2217/epi-2023-0297

    The SET gene has four transcripts reported in NCBI, coding two isoforms of SET proteins. The most known function of SET protein is inhibiting protein phosphatase 2A, a tumor suppressor, which has been associated with different biological processes. In this review, our focus was on exploring the other SET functions related to epigenetic mechanisms, which impact cellular migration, cell cycle and apoptosis.

    Tweetable abstract

    SET protein is responsible for regulating essential epigenetic processes. The disrupted function of SET in cancer makes it a promising target for research.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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