We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Epigenetic modulator LSD1, a theragnostic target for potentially malignant oral disorders and malignant lesions

    Vijayashree Priyadharsini Jayaseelan

    *Author for correspondence: Tel.: +99 4112 5984;

    E-mail Address: vijayashreej.sdc@saveetha.com

    Clinical Genetics Lab, Centre for Cellular & Molecular Research, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, 600077, India

    &
    Paramasivam Arumugam

    Molecular Biology Lab, Centre for Cellular & Molecular Research, Saveetha Dental College & Hospitals, Saveetha Institute of Medical & Technical Sciences, Saveetha University, Chennai, 600077, India

    Published Online:https://doi.org/10.2217/epi-2022-0294
    Free first page

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

    • 1. Sung H, Ferlay J, Siegel RL et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. Cancer. J. Clin. 71(3), 209–249 (2021).
    • 2. Bais MV. Targeting oral cancer epigenome via LSD1. Aging (Albany NY). 9(12), 2455–2456 (2017).
    • 3. Dorna D, Paluszczak J. The emerging significance of histone lysine demethylases as prognostic markers and therapeutic targets in head and neck cancers. Cells 11(6), 1023 (2022). •• Describes the role of lysine demethylases in head and neck cancers.
    • 4. Kim D, Kim KI, Baek SH. Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases. J. Biomed. Sci. 28(1), 41 (2021).
    • 5. Bottner J, Ribbat-Idel J, Klapper L et al. Elevated LSD1 and SNAIL expression indicate poor prognosis in hypopharynx carcinoma. Int. J. Mol. Sci. 23(9), 5075 (2022). •• Describes the prognostic ability of LSD1 in hypopharynx carcinoma.
    • 6. Alsaqer SF, Tashkandi MM, Kartha VK et al. Inhibition of LSD1 epigenetically attenuates oral cancer growth and metastasis. Oncotarget. 8(43), 73372–73386 (2017). •• Describes the therapeutic strategy exerted by attenuation of LSD1.
    • 7. Sheng W, LaFleur MW, Nguyen TH et al. LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade. Cell. 174(3), 549–563.e19 (2018).
    • 8. Yuan C, Li Z, Qi B et al. High expression of the histone demethylase LSD1 associates with cancer cell proliferation and unfavorable prognosis in tongue cancer. J. Oral. Pathol. Med. 44(2), 159–65 (2015). •• Describes the prognostic ability of LSD1 in tongue cancer.
    • 9. Wang Y, Zhu Y, Wang Q et al. The histone demethylase LSD1 is a novel oncogene and therapeutic target in oral cancer. Cancer. Lett. 374(1), 12–21 (2016). • Describes LSD1 as an oncogene and therapeutic lead.
    • 10. Yang CY, Lin CK, Tsao CH et al. Melatonin exerts anti-oral cancer effect via suppressing LSD1 in patient-derived tumor xenograft models. Oncotarget. 8(20), 33756–33769 (2017).
    • 11. Zhang W, Cheng J, Diao P et al. Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1. Br. J. Cancer. 122(4), 528–538 (2020). • Describes the potential of LSD1 as a therapeutic target.
    • 12. Han Y, Xu S, Ye W et al. Targeting LSD1 suppresses stem cell-like properties and sensitizes head and neck squamous cell carcinoma to PD-1 blockade. Cell. Death. Dis. 12(11), 993 (2021). • Describes the role of LSD1 in conferring stemness to the cancer cells.
    • 13. Wangzhou K, Fu W, Li M et al. microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1. Oral. Dis. doi: 10.1111/odi.13944 (2021) (Online ahead of print). • Describes microRNA targets of LSD1.
    • 14. Alhousami T, Diny M, Ali F et al. Inhibition of LSD1 attenuates oral cancer development and promotes therapeutic efficacy of immune checkpoint blockade and YAP/TAZ inhibition. Mol. Cancer. Res. 20(5), 712–721 (2022). •• Describes the therapeutic efficacy of LSD1 in attenuating oral cancer.
    • 15. Fang Y, Liao G, Yu B. LSD1/KDM1A inhibitors in clinical trials: advances and prospects. J. Hematol. Oncol. 12(1), 129 (2019).