Research Article

Association of FSH with metabolic syndrome in postmenopausal women: a comparison with CRP, adiponectin and leptin

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Department of Laboratory Medicine, Collegium Medicum, Nicholas Copernicus University, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland

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Irena Ponikowska

Department of Balneology, Collegium Medicum, Nicholas Copernicus University, Leśna 3, 87-720 Ciechocinek, Poland

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Malgorzata Cwiklinska-Jurkowska

Department of Theoretical Foundations of Biomedical Sciences & Medical Computer Science, Collegium Medicum, Nicholas Copernicus University, Jagiellonska 15, 85-067 Bydgoszcz, Poland

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Grazyna Sypniewska

Department of Laboratory Medicine, Collegium Medicum, Nicholas Copernicus University, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland

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Published Online:13 Oct 2014https://doi.org/10.2217/bmm.14.49

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Abstract

Aim: The aim of this study was to evaluate the usefulness of follicle-stimulating hormone (FSH) determination in the postmenopausal women with metabolic syndrome (MetS) in a comparative analysis with biomarkers such as C-reactive protein (CRP), adiponectin, leptin and leptin-to-adiponectin ratio (L/A). Material & methods: 135 postmenopausal women with MetS and 153 without MetS were subjected to examinations. Results: The increase in the probability of MetS, when the value of the marker concentration decreased or increased by 1 standard deviation, was two times higher for FSH-based models than for models including CRP and leptin, and was similar to models including adiponectin and L/A. The areas under the ROC curves were 0.78 for FSH, 0.68 for CRP, 0.72 for leptin, 0.76 for adiponectin and 0.80 for L/A. Conclusions: Our results suggest that the FSH concentration assesses the probability of MetS similarly to L/A or adiponectin and better than CRP or leptin in postmenopausal women.

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Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 8, No. 7

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Published online 13 October 2014

Published in print August 2014

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Financial & competing interests disclosure

This study was supported by a grant (BW 01/2008) from the Nicolaus Copernicus University in Torun Ludwik Rydygier Collegium Medicum, Bydgoszcz, Poland. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board's approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

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