Brain autoantibodies in autism spectrum disorder

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References

• 1 CDC. Prevalence of autism spectrum disorders – autism and developmental disabilities monitoring network, 14 sites, United States, 2008. MMWR Surveill. Summ. 61(3), 1–19 (2012).
  Google Scholar
• 2 Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD). Ann. NY Acad. Sci. 1107(1), 79–91 (2007).
  Medline CASGoogle Scholar
• 3 American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders (4th Edition). American Psychiatric Association, DC, USA (2000).
  Google Scholar
• 4 Fombonne E. Epidemiology of autistic disorder and other pervasive developmental disorders. J. Clin. Psychiatry 66(10), 3–8 (2005).
  MedlineGoogle Scholar
• 5 Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. J. Leuk. Biol. 80(1), 1–15 (2006). • Review covering a variety of immunological aspects in autism spectrum disorder (ASD).
  Medline CASGoogle Scholar
• 6 Croen LA, Braunschweig D, Haapanen L et al. Maternal mid-pregnancy autoantibodies to fetal brain protein: the Early Markers for Autism study. Biol. Psychiatry 64(7), 583–588 (2008).
  Medline CASGoogle Scholar
• 7 Ratajczak HV. Theoretical aspects of autism: causes – a review. J. Immunotoxicol. 8(1), 68–79 (2011).
  MedlineGoogle Scholar
• 8 Malkova NV, Yu CZ, Hsiao EY, Moore MJ, Patterson PH. Maternal immune activation yields offspring displaying mouse versions of the three core symptoms of autism. Brain Behav. Immun. 26(4), 607–616 (2012).
  Medline CASGoogle Scholar
• 9 Sweeten TL, Bowyer SL, Posey DJ, Halberstadt GM, McDougle CJ. Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics 112(5), e420–e424 (2003).
  MedlineGoogle Scholar
• 10 Cohly HH, Panja A. Immunological findings in autism. Int. Rev. Neurobiol. 71, 317–341 (2005).
  Medline CASGoogle Scholar
• 11 Singer HS, Morris CM, Williams PN, Yoon DY, Hong JJ, Zimmerman AW. Antibrain antibodies in children with autism and their unaffected siblings. J. Neuroimmunol. 178(1), 149–155 (2006).
  Medline CASGoogle Scholar
• 12 Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism. Ann. Clin. Psychiatry 21(3), 148–161 (2009).
  MedlineGoogle Scholar
• 13 Singh VK, Jensen RL. Elevated levels of measles antibodies in children with autism. Pediatr. Neurol. 28(4), 292–294 (2003).
  MedlineGoogle Scholar
• 14 Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. Int. Rev. Psychiat. 17(6), 485–495 (2005).
  MedlineGoogle Scholar
• 15 Odell D, Maciulis A, Cutler A et al. Confirmation of the association of the C4B null allelle in autism. Hum. Immunol. 66(2), 140–145 (2005).
  Medline CASGoogle Scholar
• 16 Watts TJ. The pathogenesis of autism. Clin. Med. Pathol. 1, 99–103 (2008).
  MedlineGoogle Scholar
• 17 Mostafa GA, Shehab AA, Al-Ayadhi LY. The link between some alleles on human leukocyte antigen system and autism in children. J. Neuroimmunol. 255(1–2), 70–74 (2013).
  MedlineGoogle Scholar
• 18 Braunschweig D, Ashwood P, Krakowiak P et al. Autism: maternally derived antibodies specific for fetal brain proteins. NeuroToxicology 29( 2), 226–231 (2008). • Highlights the possible role of maternal autoantibodies in the pathogenesis of ASD.
  MedlineGoogle Scholar
• 19 Nordahl CW, Braunschweig D, Iosif AM et al. Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder. Brain Behav. Immun. 30, 61–65 (2013).
  Medline CASGoogle Scholar
• 20 Bauman MD, Iosif AM, Ashwood P et al. Maternal antibodies from mothers of children with autism alter brain growth and social behavior development in the rhesus monkey. Transl. Psychiatry 3, e278 (2013).
  Medline CASGoogle Scholar
• 21 Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J. Child Neurol. 14(6), 388–394 (1999).
  Medline CASGoogle Scholar
• 22 Mostafa GA, Al-Ayadhi LY. The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children. J. Neuroimmunol. 261(1–2), 77–81 (2013).
  Medline CASGoogle Scholar
• 23 Diamond B, Huerta PT, Mina-Osorio P, Kowal C, Volpe BT. Losing your nerves? Maybe it’s the antibodies. Nat. Rev. Immunol. 9(6), 445–456 (2009).
  Google Scholar
• 24 Singh VK, Warren RP, Odell JD, Warren WL, Cole P. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav. Immun. 7(1), 97–103 (1993).
  Medline CASGoogle Scholar
• 25 Singh VK, Rivas WH. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci. Lett. 355(1–2), 53–56 (2004).
  Medline CASGoogle Scholar
• 26 Mostafa GA, Kitchener N. Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children. Pediatr. Neurol. 40(2), 107–112 (2009).
  MedlineGoogle Scholar
• 27 Mostafa GA, Al-Ayadhi LY. Increased serum levels of anti-ganglioside M1 autoantibodies in autistic children: relation to the disease severity. J. Neuroinflammation 8, 39 (2011).
  Medline CASGoogle Scholar
• 28 Mostafa GA, Al-Ayadhi LY. The relationship between the increased frequency of serum antineuronal antibodies and the severity of autism in children. Eur. J. Paediatr. Neurol. 16(5), 464–468 (2012).
  MedlineGoogle Scholar
• 29 Rossi CC, Joaquin Fuentes J, Van de Water J, Amaral DG. Brief report: antibodies reacting to brain tissue in Basque Spanish children with autism spectrum disorder and their mothers. J. Autism Dev. Disord. doi:10.1007/s10803-013-1859-y (2013) (Epub ahead of print).
  Google Scholar
• 30 Vural B, Ugurel E, Tuzun E et al. Anti-neuronal and stress induced-phosphoprotein 1 antibodies in neuro-Behcet’s disease. J. Neuroimmunol. 239, 91–97 (2011).
  Medline CASGoogle Scholar
• 31 Hensley K, Venkova K, Christov A, Gunning W, Park J. Collapsin response mediator protein-2: an emerging pathologic feature and therapeutic target for neurodisease indications. Mol. Neurobiol. 43, 180–191 (2011).
  Medline CASGoogle Scholar
• 32 Frye RE, Sequeira JM, Quadros EV, James SJ, Rossignol DA. Cerebral folate receptor autoantibodies in autism spectrum disorder. Mol. Psychiatry 18, 369–381 (2013).
  Medline CASGoogle Scholar
• 33 Aboul-Enein F, Rauschka H, Kornek B et al. Preferential loss of myelin-associated glycoprotein reflects hypoxia like white matter damage in stroke and inflammatory brain diseases. J. Neuropathol. Exp. Neurol. 62(1), 25–33 (2003).
  Medline CASGoogle Scholar
• 34 Mostafa GA, Al-Ayadhi LY. A lack of association between hyperserotonemia and the increased frequency of serum anti-myelin basic protein auto-antibodies in autistic children. J. Neuroinflammation 8, 71 (2011).
  Medline CASGoogle Scholar
• 35 Angelucci F, Mirabella M, Frisullo G, Caggiula M, Tonali PA, Batocchi AP. Serum levels of anti-myelin antibodies in relapsing-remitting multiple sclerosis patients during different phases of disease activity and immunomodulatory therapy. Dis. Markers 21, 49–55 (2005).
  Medline CASGoogle Scholar
• 36 Hedegaard CJ, Chen N, Sellebjerg F et al. Autoantibodies to myelin basic protein (MBP) in healthy individuals and in patients with multiple sclerosis: a role in regulating cytokine responses to MBP. Immunology 128, e451–e461 (2009).
  MedlineGoogle Scholar
• 37 Nelson KB, Grether JK, Croen LA et al. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann. Neurol. 49, 597–606 (2001).
  Medline CASGoogle Scholar
• 38 Connolly AM, Chez M, Streif EM et al. Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau–Kleffner syndrome, and epilepsy. Biol. Psychiatry 59 (4), 354–363 (2006).
  Medline CASGoogle Scholar
• 39 Hashimoto K, Iwata Y, Nakamura K et al. Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 1529–1531 (2006).
  Medline CASGoogle Scholar
• 40 Moeller S, Lau NM, Green PH et al. Lack of association between autism and anti-GM1 ganglioside antibody. Neurology 81(18), 1640–1641 (2013).
  MedlineGoogle Scholar
• 41 Careaga M, Hansen RL, Hertz-Piccotto I, Van de Water J, Ashwood P. Increased anti-phospholipid antibodies in autism spectrum disorders. Mediators Inflamm. 2013, 935608 (2013).
  MedlineGoogle Scholar
• 42 Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr. Neurol. 17(1), 88–90 (1997).
  Medline CASGoogle Scholar
• 43 Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK. Serum autoantibodies to brain in Landau–Kleffner variant, autism, and other neurologic disorders. J. Pediatr. 134(5), 607–613 (1999).
  Medline CASGoogle Scholar
• 44 Goines P, Haapanen L, Boyce R et al. Autoantibodies to cerebellum in children with autism associate with behavior. Brain. Behav. Immun. 25(3), 514–523 (2011).
  Medline CASGoogle Scholar
• 45 Silva SC, Correia C, Fesel C et al. Autoantibody repertoires to brain tissue in autism nuclear families. J. Neuroimmunol. 152(1–2), 176–182 (2004).
  Medline CASGoogle Scholar
• 46 Vojdani A, O’Bryan T, Green JA et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr. Neurosci. 7(3), 151–161 (2004).
  Medline CASGoogle Scholar
• 47 Chez MG, Connolly AM, Nowinski C, Buchanan C. The presence of autoantibodies in idiopathic/acquired versus genetic variants of pediatric epilepsy. Epilepsia 41S, 183 (2000).
  Google Scholar
• 48 Aschner M, Allen JW, Kimelberg HK, LoPachin RM, Streit WJ. Glial cells in neurotoxicity development. Annu. Rev. Pharmacol. Toxicol. 39, 151–173 (1999).
  Medline CASGoogle Scholar
• 49 Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann. Neurol. 57(1), 67–81 (2005).
  MedlineGoogle Scholar
• 50 Mazur-Kolecka B, Cohen IL, Gonzalez M et al. Autoantibodies against neuronal progenitors in sera from children with autism. Brain Dev. doi:10.1016/j.braindev.04.015 (2013) (Epub ahead of print).
  MedlineGoogle Scholar
• 51 Rossi CC, Van de Water J, Rogers SJ, Amaral DG. Detection of plasma autoantibodies to brain tissue in young children with and without autism spectrum disorders. Brain Behav. Immun. 25, 1123–1135 (2011).
  Medline CASGoogle Scholar
• 52 Dalton P, Deacon R, Blamire A et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann. Neurol. 53(4), 533–537 (2003). • First study to administer maternal plasma containing autoantibodies to gestating mice to study their role on behavioral deficits in ASD children.
  MedlineGoogle Scholar
• 53 Singer HS, Moriss CM, Gause CD, Gillin PK, Crawford S, Zimmerman AW. Antibodies against fetal brain in sera of mothers with autistic children. J. Neuroimmunol. 194(1–2), 165–172 (2008)
  Medline CASGoogle Scholar
• 54 Schwartzer JJ, Careaga M, Onore CE, Rushakoff JA, Berman RF, Ashwood P. Maternal immune activation and strain specific interactions in the development of autism-like behaviors in mice. Transl. Psychiatry 12, e240 (2013).
  Google Scholar
• 55 Zimmerman AW, Connors SL, Matteson KJ et al. Maternal antibrain antibodies in autism. Brain Behav. Immun. 21, 351–357 (2007).
  Medline CASGoogle Scholar
• 56 Fox E, Amaral D, Van de Water J. Maternal and fetal anti-brain antibodies in development and disease. Develop. Neurobiol. 72(10), 1327–1334 (2012).
  Medline CASGoogle Scholar
• 57 Braunschweig D, Golub MS, Koenig CM et al. Maternal autism-associated IgG antibodies delay development and produce anxiety in a mouse gestational transfer model. J. Neuroimmunol. 252(1–2), 56–65 (2012).
  Medline CASGoogle Scholar
• 58 Gesundheit B, Rosenzweig JP, Naor D et al. Immunological and autoimmune considerations of autism spectrum disorders. J. Autoimmun. 44, 1–7 (2013).
  Medline CASGoogle Scholar
• 59 Brimberg L, Sadiq A, Gregersen PK, Diamond B. Brain-reactive IgG correlates with autoimmunity in mothers of a child with an autism spectrum disorder. Mol. Psychiatry 18, 1171–1177 (2013). • Study on a large cohort of mothers of ASD children to assess the association of brain autoantibody reactivity with autoimmunity.
  Medline CASGoogle Scholar
• 60 Atladottir HO, Pedersen MG, Thorsen P et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 124, 687–694 (2009).
  MedlineGoogle Scholar
• 61 Patterson PH. Modeling autistic features in animals. Pediatr. Res. 69(3), 34R–40R (2011).
  MedlineGoogle Scholar
• 62 Heo Y, Zhang Y, Gao D, Miller VM, Lawrence DA. Aberrant immune responses in a mouse with behavioral disorders. PLoS ONE 6(7), e20912 (2011). • Describes the role of immune responses in behavioral deficit in BTBR mice.
  Medline CASGoogle Scholar
• 63 Onore CE, Careaga M, Babineau BA, Schwartzer JJ, Berman RF, Ashwood A. Inflammatory macrophage phenotype in BTBR T+tf/J mice. Front. Neurosci. 7, 158 (2013).
  MedlineGoogle Scholar
• 64 Braunschweig D, Krakowiak P, Duncanson P et al. Autism-specific maternal autoantibodies recognize critical proteins in developing brain. Transl. Psychiatry 3, e277 (2013). •• Describes six new biomarkers that are specific for ASD.
  Medline CASGoogle Scholar
• 65 Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J. Neurosci. 23(1), 297–302 (2003).
  MedlineGoogle Scholar
• 66 Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav. Immun. 22(6), 806–816 (2008).
  Medline CASGoogle Scholar
• 67 Singer HS, Morris C, Gause C, Pollard M, Zimmerman AW, Pletnikov M. Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: a pregnant dam mouse model. J. Neuroimmunol. 211(1–2), 39–48 (2009).
  Medline CASGoogle Scholar
• 68 Volkmar FR, Lord C, Bailey A, Schultz RT, Klin A. Autism and pervasive developmental disorders. J. Child Psychol. Psychiatry 45(1), 135–170 (2004).
  MedlineGoogle Scholar
• 69 Russo AJ, Krigsman A, Jepson B, Wakefield A. Generalized autoimmunity of ANCA and ASCA related to severity of disease in autistic children with GI disease. Immunol. Immunogenet. Insights 1, 37–47 (2009).
  CASGoogle Scholar