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Fecal calprotectin as an intestinal inflammation marker is elevated in glaucoma

    Zuo Wang

    Department of Clinical Laboratory, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science & Technology of China, Chengdu, China

    ,
    Hang Yuan

    Department of Immunology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, China

    ,
    Xiong Zhu

    Department of Prenatal Diagnosis, Chengdu Women’s & Children’s Central Hospital, School of Medicine, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Jinxia Wang

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Wenbo Xiu

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Yang Chen

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Gao Zhang

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Jing Fu

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Kun Peng

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    An Li

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Donghua Liu

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Xijing Huang

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    ,
    Chong He

    *Author for correspondence:

    E-mail Address: herrickhoo@163.com

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science & Technology of China, Chengdu, China

    &
    Fang Lu

    **Author for correspondence:

    E-mail Address: lufangfang@126.com

    Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    Medico-Engineering Cooperation on Applied Medicine Research Center, University of Electronic Science & Technology of China, Chengdu, China

    Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science & Technology of China, Chengdu, China

    Published Online:https://doi.org/10.2217/bmm-2023-0352

    Objective: The aim of this study was to investigate the potential association between glaucoma and fecal calprotectin. Methods: A total of 144 glaucomatous patients and 66 healthy controls were enlisted for this study. The fecal calprotectin was assessed using enzyme-linked immunosorbent assay. Results: The median fecal calprotectin levels were significantly elevated in glaucoma (73.67 vs 41.97 μg/g; p < 0.001), primary angle-closure glaucoma (76.85 μg/g; p < 0.001) and primary open-angle glaucoma (69.29 μg/g; p = 0.016) groups compared with controls. A notable proportion of the glaucoma (24%; p < 0.001), primary angle-closure glaucoma (21%; p < 0.001) and primary open-angle glaucoma (24%; p < 0.001) subgroups exhibited highly abnormal fecal calprotectin levels (≥250 μg/g). Conclusion: Elevated fecal calprotectin might indicate potential intestinal inflammation in glaucoma.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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