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Downregulation of LINC00515 in high-grade serous ovarian cancer and its relationship with platinum resistance

    Mao-Wei Ni

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    Key Laboratory Diagnosis & Treatment Technology on Thoracic Oncology of Zhejiang Province, Hangzhou, Zhejiang, PR China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Jie Zhou

    Center for Medicinal Resources Research, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang, PR China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Ying-Li Zhang

    Department of Gynecologic Oncology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Guo-Ming Zhou

    Laboratory Medicine, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Sheng-Jie Zhang

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Jian-Guo Feng

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Qiang Xu

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Yun Zhou

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    ,
    Han-Zhou Mou

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    &
    Zhi-Guo Zheng

    *Author for correspondence:

    E-mail Address: zhengzg@zjcc.org.cn

    Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, PR China

    Key Laboratory of Head & Neck Cancer Translational Research of Zhejiang Province, Hangzhou, Zhejiang, PR China

    Published Online:https://doi.org/10.2217/bmm-2018-0382

    Aim: To investigate the expression of long intergenic noncoding RNA 00515 (LINC00515) in high-grade serous ovarian cancer (HGSOC) and its potential correlation with platinum resistance. Patients & methods: Expression of LINC00515 in HGSOC (n = 115) and normal (n = 19) tissues was detected via quantitative real-time PCR (qRT-PCR). We further explored the statistical significance of the relationship between LINC00515 expression and platinum resistance in HGSOC. Results: LINC00515 was gradually downregulated in the order of normal > platinum-sensitive > platinum-resistant tissue (p < 0.05). Results demonstrated that LINC00515 downregulation was correlated with platinum resistance and relapse-free survival (RFS) of HGSOC (p < 0.05). Conclusion: LINC00515 downregulation is correlated with HGSOC development, platinum resistance and RFS, supporting its utility as a potential biomarker to predict platinum resistance and prognosis of RFS.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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