Review

Department of Traumatic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China

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Xiaojing Dai

MD Anderson Cancer Center, The Advanced Technology Genomics Core, Houston, TX 77030, USA

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Yong Li

*Author for correspondence:

E-mail Address: Yong.li@med.wmich.edu

https://orcid.org/0000-0001-7956-9600

Department of Orthopedic Surgery & Biomedical Engineering, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI 49008, USA

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Published Online:31 Mar 2021https://doi.org/10.2217/rme-2020-0066

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Abstract

Numerous individuals suffer from impaired wound healing, such as chronic ulcers, severe burns and immune disorders, resulting in both public health and economic burdens. Skin is the first line of defense and the largest organ of the human body, however, an incomplete understanding of underlying cellular and molecular mechanisms of dermal repair leads to a lack of effective therapy for healing impaired wounds. There are strong clinical and social needs for improved therapeutic approaches to enhance endogenous tissue repair and regenerative capacity. The purpose of this review is to illuminate the cellular and molecular aspects of the healing process and highlight potential therapeutic strategies to accelerate translational research and the development of clinical therapies in dermal wounds.

Keywords:

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Vol. 16, No. 4

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History

Received 6 May 2020

Accepted 10 March 2021

Published online 31 March 2021

Published in print April 2021

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Keywords

Author contributions

F Yang made substantial contributions to the conception and design, and participated in drafting the manuscript and graphics. X Bai participated in drafting the manuscript. X Dai participated in drafting the manuscript and parts of graphics. Y Li wrote, edited and gave final approval of the version to be submitted and any revised versions.

Acknowledgments

The authors thanked M Hall, N Nakamura, Tolsma R and Patrick Li for their critical discussion and help to edit this manuscript. They sincerely apologize for the inadvertent omission of any pertinent original references owing to space constraints.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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The biological processes during wound healing

Abstract

References