Short Communication

Elevated expression of ASF1B correlates with poor prognosis in human lung adenocarcinoma

Department of Radiation Oncology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, PR China

Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, PR China

‡Authors contributed equally

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Jiao Zhang‡

Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, Tianjin 300060, PR China

Department of General Surgery, Tianjin Fifth Central Hospital, Tianjin 300450, PR China

‡Authors contributed equally

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Yafang Zheng

Department of Radiation Oncology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, PR China

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Qingzhang Wang

Department of Radiation Oncology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, PR China

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Xiaochuan Min

Department of Radiation Oncology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, PR China

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Tieshuan Tian

*Author for correspondence:

E-mail Address: radiotherapytjch@126.com

https://orcid.org/0000-0003-0545-9948

Department of Radiation Oncology, Tianjin Chest Hospital, Tianjin Cardiovascular Disease Research Institute, Tianjin 300222, PR China

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Published Online:12 Feb 2021https://doi.org/10.2217/pme-2020-0112

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Abstract

Aim: ASF1 is involved in tumorigenesis. However, its possible role in lung adenocarcinoma (LUAD) is unclear. This study thus explored the role of ASF1A and ASF1B in LUAD. Materials & methods: Data from The Cancer Genome Atlas and Gene Expression Omnibus were employed to investigate ASF1A and ASF1B expression and its roles in LUAD prognosis. Immunohistochemistry was applied to determine the protein expression of ASF1B of 30 LUAD patients. Results: The upregulation of ASF1B in tumor tissues is associated with worse overall survival and progress-free survival and is correlated with advanced tumor stage and tumor development. However, aberrant expression of ASF1A was not found in LUAD and ASF1A was not related to patients’ overall survival and progress-free survival. Conclusion:ASF1B could be a promising prognostic and therapeutic biomarker in LUAD.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 18, No. 2

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History

Received 12 May 2020

Accepted 29 October 2020

Published online 12 February 2021

Published in print March 2021

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Keywords

Author contributions

Z Feng and Y Zheng conceived and designed the study, performed the statistical analysis and wrote the manuscript. J Zhang and Q Wang collected the data. X Min and T Tian revised the manuscript. All authors read and approved the final manuscript.

Acknowledgments

The authors thanked L Xu for technical and material support.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations. In addition, for investigations involving human subjects, informed consent has been obtained from the participants involved.

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