IL-27 genetic variation and susceptibility of dilated cardiomyopathy in Chinese Han population

Papers of special note have been highlighted as: • of interest

References

• 1 Elliott P, Andersson B, Arbustini E et al. Classification of the cardiomyopathies: a position statement from the European Society of Cardiology Working Group on Myocardial and Pericardial Diseases. Eur. Heart J. 29(2), 270–276 (2008).
  MedlineGoogle Scholar
• 2 Zimmermann O, Kochs M, Zwaka TP et al. Myocardial biopsy based classification and treatment in patients with dilated cardiomyopathy. Int. J. Cardiol. 104(1), 92–100 (2005).
  MedlineGoogle Scholar
• 3 Caforio AL, Mahon NG, Baig MK et al. Prospective familial assessment in dilated cardiomyopathy: cardiac autoantibodies predict disease development in asymptomatic relatives. Circulation 115(1), 76–83 (2007).
  MedlineGoogle Scholar
• 4 Marriott JB, Goldman JH, Keeling PJ, Baig MK, Dalgleish AG, Mckenna WJ. Abnormal cytokine profiles in patients with idiopathic dilated cardiomyopathy and their asymptomatic relatives. Heart 75(3), 287–290 (1996).
  Medline CASGoogle Scholar
• 5 Herda LR, Felix SB, Staudt A. Immunoadsorption in patients with dilated cardiomyopathy. Atheroscler. Suppl. 10(5), 126–128 (2009).
  Medline CASGoogle Scholar
• 6 Frustaci A, Chimenti C, Calabrese F, Pieroni M, Thiene G, Maseri A. Immunosuppressive therapy for active lymphocytic myocarditis: virological and immunologic profile of responders versus nonresponders. Circulation 107(6), 857–863 (2003).
  MedlineGoogle Scholar
• 7 Pflanz S, Timans JC, Cheung J et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4⁺ T cells. Immunity 16(6), 779–790 (2002).
  Medline CASGoogle Scholar
• 8 Neurath MF. New therapies for sepsis: focus on the interleukin (IL)12 family member IL27. Ann. Rheum. Dis. 66(Suppl. 3), iii29–iii31 (2007).
  Medline CASGoogle Scholar
• 9 Shen Y, Yuan XD, Hu D et al. Association between interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis. Hum. Immunol. 75(9), 991–995 (2014).
  Medline CASGoogle Scholar
• 10 Wang Z, Wang L, Fan R, Zhou J, Zhong J. Association of IL-27 gene three polymorphisms with Crohn's disease susceptibility in a Chinese Han population. Int. J. Clin. Exp. Pathol. 7(12), 8952–8957 (2014).
  MedlineGoogle Scholar
• 11 Yamamoto-Furusho JK, Posadas-Sanchez R, Alvarez-Leon E, Vargas-Alarcon G. Protective role of Interleukin 27 (IL-27) gene polymorphisms in patients with ulcerative colitis. Immunol. Lett. 172, 79–83 (2016).
  Medline CASGoogle Scholar
• 12 Zhang D, Ma M, Yang Y et al. Association between polymorphisms in IL27 and risk for CHD in a Chinese population. Cardiol. Young 26(2), 237–243 (2016).
  MedlineGoogle Scholar
• 13 Richardson P, Mckenna W, Bristow M et al. Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation 93(5), 841–842 (1996). • Proposes the definition of cardiomyopathies, which are classified as dilated cardiomyopathy, hypertrophic cardiomyopathy, restrictive cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy and unclassified cardiomyopathies.
  Medline CASGoogle Scholar
• 14 Zhou B, Zhang P, Tang T et al. Polymorphisms and plasma levels of IL-27: impact on genetic susceptibility and clinical outcome of bladder cancer. BMC Cancer 15, 433 (2015).
  MedlineGoogle Scholar
• 15 Sole X, Guino E, Valls J, Iniesta R, Moreno V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 22(15), 1928–1929 (2006).
  Medline CASGoogle Scholar
• 16 Fu M. Autoimmunity in idiopathic dilated cardiomyopathy: from patients to molecules and back to patients. Int. J. Cardiol. 112(1), 1 (2006). • Suggests multiple autoimmune are pathophysiologically involved in the pathogenesis of dilated cardiomyopathy and can provide scope for therapeutic approaches.
  MedlineGoogle Scholar
• 17 Staudt A, Schaper F, Stangl V et al. Immunohistological changes in dilated cardiomyopathy induced by immunoadsorption therapy and subsequent immunoglobulin substitution. Circulation 103(22), 2681–2686 (2001).
  Medline CASGoogle Scholar
• 18 Satoh M, Tamura G, Segawa I, Tashiro A, Hiramori K, Satodate R. Expression of cytokine genes and presence of enteroviral genomic RNA in endomyocardial biopsy tissues of myocarditis and dilated cardiomyopathy. Virchows Arch. 427(5), 503–509 (1996).
  Medline CASGoogle Scholar
• 19 Villarino AV, Huang E, Hunter CA. Understanding the pro- and anti-inflammatory properties of IL-27. J. Immunol. 173(2), 715–720 (2004).
  Medline CASGoogle Scholar
• 20 Carl JW, Bai XF. IL27: its roles in the induction and inhibition of inflammation. Int. J. Clin. Exp. Pathol. 1(2), 117–123 (2008).
  Medline CASGoogle Scholar
• 21 Artis D, Villarino A, Silverman M et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J. Immunol. 173(9), 5626–5634 (2004).
  Medline CASGoogle Scholar
• 22 Goldberg R, Zohar Y, Wildbaum G, Geron Y, Maor G, Karin N. Suppression of ongoing experimental autoimmune encephalomyelitis by neutralizing the function of the p28 subunit of IL-27. J. Immunol. 173(10), 6465–6471 (2004).
  Medline CASGoogle Scholar
• 23 Zhu H, Lou C, Liu P. Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells. Virol J. 12, 189 (2015). • Indicates IL-27 plays an important role in the pathogenesis of CVB3-induced myocarditis, and can effectively reduce Th17 production.
  MedlineGoogle Scholar
• 24 Badorff C, Knowlton KU. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside. Med. Microbiol. Immunol. 193(2–3), 121–126 (2004).
  Medline CASGoogle Scholar
• 25 Takeda A, Hamano S, Yamanaka A et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170(10), 4886–4890 (2003).
  Medline CASGoogle Scholar
• 26 Hoffmann SC, Stanley EM, Darrin Cox E et al. Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. Transplantation 72(8), 1444–1450 (2001).
  Medline CASGoogle Scholar
• 27 Yu W, Zhang K, Wang Z, Zhang J, Chen T, Jin L. Functional variant in the promoter region of IL-27 alters gene transcription and confers a risk for ulcerative colitis in northern Chinese Han. Hum. Immunol. 78(3), 287–293 (2017). • Indicates IL-27 plays an important role in the pathogenesis of CVB3-induced myocarditis, and can effectively reduce Th17 production.
  Medline CASGoogle Scholar
• 28 Felker GM, Hu W, Hare JM, Hruban RH, Baughman KL, Kasper EK. The spectrum of dilated cardiomyopathy. The Johns Hopkins experience with 1278 patients. Medicine (Baltimore) 78(4), 270–283 (1999).
  Medline CASGoogle Scholar
• 29 QUANTO1.1:A computer program for power and sample size calculations for genetic-epidemiologystudies. http://hydra.usc.edu/gxe.
  Google Scholar