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Genome-wide association studies in pharmacogenomics of antidepressants

    Eugene Lin

    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

    Vita Genomics, Inc., 7 Fl., No. 6, Sec. 1, Jung-Shing Road, Wugu Shiang, Taipei, Taiwan

    &
    Hsien-Yuan Lane

    *Author for correspondence:

    E-mail Address: hylane@gmail.com

    Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan

    Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan

    Published Online:https://doi.org/10.2217/pgs.15.5

    Major depressive disorder (MDD) is one of the most common psychiatric disorders worldwide. Doctors must prescribe antidepressants based on educated guesses due to the fact that it is unmanageable to predict the effectiveness of any particular antidepressant in an individual patient. With the recent advent of scientific research, the genome-wide association study (GWAS) is extensively employed to analyze hundreds of thousands of single nucleotide polymorphisms by high-throughput genotyping technologies. In addition to the candidate-gene approach, the GWAS approach has recently been utilized to investigate the determinants of antidepressant response to therapy. In this study, we reviewed GWAS studies, their limitations and future directions with respect to the pharmacogenomics of antidepressants in MDD.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest.

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