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Application of next-generation sequencing in diffuse large B-cell lymphoma

    Yudi Wang

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    ,
    Suzhen Jia

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    ,
    Xiubo Cao

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    ,
    Shengchen Ge

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    ,
    Kang Yu

    *Author for correspondence: Tel.: +86 138 0668 1379;

    E-mail Address: yukang1379@163.com

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    &
    Yi Chen

    **Author for correspondence: Tel.: +86 136 0066 2969;

    E-mail Address: chenyi2969@163.com

    Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China

    Published Online:https://doi.org/10.2217/pgs-2022-0140

    Summary

    Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of invasive non-Hodgkin lymphoma. There is great heterogeneity in its molecular biological characteristics, clinical manifestations and prognosis. The use of rituximab has greatly improved the cure rate of DLBCL, but there are still 30% of patients with poor prognosis. In the era of precision medicine, the significance of molecular biology and genetic factors on the diagnosis, treatment and prognosis of patients has been found. Among these, next-generation sequencing technology plays an important role. This paper reviews the research progress of next-generation sequencing technology in the classification, diagnosis, prognosis and molecular targeted therapy of DLBCL.

    Graphical abstract

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