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Should a routine genotyping of CYP2D6 and CYP2C19 genetic polymorphisms be recommended to predict venlafaxine efficacy in depressed patients treated in psychiatric settings?

    Adela Taranu

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    ,
    Romain Colle

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    Service de Psychiatrie, Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    ,
    Florence Gressier

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    Service de Psychiatrie, Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    ,
    Khalil El Asmar

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    ,
    Laurent Becquemont

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    Centre de Recherche Clinique (CRC), Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    ,
    Emmanuelle Corruble

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    Service de Psychiatrie, Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    &
    Céline Verstuyft

    *Author for correspondence:

    E-mail Address: celine.verstuyft@aphp.fr

    INSERM UMR1178, Team (Depression & Antidepressants), Faculté de Médecine Paris-Sud, Univ. Paris-Sud, Le Kremlin Bicêtre, France

    Service de Génétique Moléculaire, Pharmacogénétique et Hormonologie, Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    Centre de Ressources Biologiques, CRB Paris-Sud, Hôpital Bicêtre, Groupe Hospitalier Paris Sud, AP-HP, Le Kremlin Bicêtre, France

    Published Online:https://doi.org/10.2217/pgs-2017-0003

    Aim: The antidepressant venlafaxine (VEN) is metabolized by CYP2D6 and CYP2C19. The aim of this study was to assess the relevance of generalizing to daily practice the genotyping of CYP2D6 and CYP2C19 to predict VEN efficacy in depressed patients treated in psychiatric settings. Patients & Methods: This study was nested in a naturalistic cohort, with 206 patients requiring a new antidepressant treatment and genotyped for CYP2D6 *3, *4, *5 del, *6, *2xN, *10, *41 and CYP2C19 *2, *3, *4, *5, *17 alleles. Results: CYP2D6 and CYP2C19 phenotypes were associated neither with the Hamilton depression rating scale score improvement, nor with response and remission. Conclusion: Routine CYP2D6 and CYP2C19 genotyping cannot be recommended to predict VEN efficacy in depressed patients treated in psychiatry settings.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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