Systematic Review

MTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: evidence of a case–control study and meta-analysis

Bone and Joint Reconstruction Research Center, Shafa Yahyaeian Orthopedics Hospital, Iran University of Medical Sciences, Tehran, Iran

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Batoul Sadat Haerian

*Author for correspondence:

E-mail Address: batoolsadat@yahoo.com

Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Saadat Molanaei

Department of Pathology, Milad Hospital, Tehran, Iran

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Farid Kosari

Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran

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Shahram Sabeti

Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Farahnaz Bidari-Zerehpoosh

Department of Pathology, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Ebrahim Abdolali

Department of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

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Mohammad Reza Zali

Gastroenterology & Liver Diseases Research Center (GLDRC), Shahid Beheshti University of Medical Science, Tehran, Iran

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Published Online:28 Oct 2016https://doi.org/10.2217/pgs-2016-0048

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Abstract

Several studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case–control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case–control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Published online 28 October 2016

Published in print November 2016

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Acknowledgements

The authors gratefully acknowledge the Iranians subjects for their participation in this study. The authors also thank Farzaneh Niki Boroujeni, Sepideh Homaye Nikfar, Soudabeh Yousef Nya and Zahra Jaefari, the staff of Sina hospital for their kind assistance in recruiting of FFPE and blood samples.

Financial & competing interests disclosure

This work was supported by the 645/646 SBUMS Research Grants, Iran. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

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