Polymersomes and their applications in cancer delivery and therapy

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1 Stewart BW, Wild CP. World Cancer Report 2014. IARC Nonserial Publication, Switzerland (2014).
  Google Scholar
• 2 Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J. Clin. 63(1), 11–30 (2013).
  MedlineGoogle Scholar
• 3 Yamauchi T, Yoshida A, Ueda T. Camptothecin induces DNA strand breaks and is cytotoxic in stimulated normal lymphocytes. Oncol. Rep. 25(2), 347–352 (2011).
  Medline CASGoogle Scholar
• 4 Fujita-Yamaguchi Y. Renewed interest in basic and applied research involving monoclonal antibodies against an oncofetal Tn-antigen. J. Biochem. 154(2), 103–105 (2013).
  Medline CASGoogle Scholar
• 5 Chandramohan V, Mitchell DA, Johnson LA, Sampson JH, Bigner DD. Antibody, T-cell and dendritic cell immunotherapy for malignant brain tumors. Future Oncol. 9(7), 977–990 (2013).
  CASGoogle Scholar
• 6 Kapur R, Einarsdottir HK, Vidarsson G. IgG-effector functions: “The Good, The Bad and The Ugly”. Immunol. Lett. 162(2), 139–144 (2013).
  Google Scholar
• 7 Fakhrejahani E, Toi M. Antiangiogenesis therapy for breast cancer: an update and perspectives from clinical trials. Jpn. J. Clin. Oncol. 44(3), 197–207 (2014).
  MedlineGoogle Scholar
• 8 Li X, Kimberly RP. Targeting the Fc receptor in autoimmune disease. Expert Opin. Ther. Targets 18(3), 335–350 (2014).
  Medline CASGoogle Scholar
• 9 Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 46(12 Pt 1), 6387–6392 (1986).
  Medline CASGoogle Scholar
• 10 Maeda H. Macromolecular therapeutics in cancer treatment: the EPR effect and beyond. J. Control. Release 164(2), 138–144 (2012).
  Medline CASGoogle Scholar
• 11 Fang J, Nakamura H, Maeda H. The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Adv. Drug Deliv. Rev. 63(3), 136–151 (2011).
  Medline CASGoogle Scholar
• 12 Maeda H, Nakamura H, Fang J. The EPR effect for macromolecular drug delivery to solid tumors: improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo. Adv. Drug Deliv. Rev. 65(1), 71–79 (2013).•• A historical review of enhanced permeability and retention effect, on its features and consequential benefits in tumor-selective delivery of nanoparticles.
  Medline CASGoogle Scholar
• 13 Maeda H. Vascular permeability in cancer and infection as related to macromolecular drug delivery, with emphasis on the EPR effect for tumor-selective drug targeting. Proc. Japan Acad. B 88(3), 53–71 (2012).
  CASGoogle Scholar
• 14 Duncan R. Polymer conjugates as anticancer nanomedicines. Nat. Rev. Cancer 6(9), 688–701 (2006).
  Medline CASGoogle Scholar
• 15 Greish K. Enhanced permeability and retention (EPR) effect for anticancer nanomedicine drug targeting. Cancer Nanotechnol. 624, 25–37 (2010).
  CASGoogle Scholar
• 16 Duncan R. The dawning era of polymer therapeutics. Nat. Rev. Drug Discov. 2(5), 347–360 (2003).
  Medline CASGoogle Scholar
• 17 Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2(12), 751–760 (2007).
  Medline CASGoogle Scholar
• 18 Dombu CY, Betbeder D. Airway delivery of peptides and proteins using nanoparticles. Biomaterials 34(2), 516–525 (2013).
  Medline CASGoogle Scholar
• 19 Pichon C, Billiet L, Midoux P. Chemical vectors for gene delivery: uptake and intracellular trafficking. Curr. Opin. Biotechnol. 21(5), 640–645 (2010).
  Medline CASGoogle Scholar
• 20 Liboiron BD, Mayer LD. Nanoscale particulate systems for multidrug delivery: towards improved combination chemotherapy. Ther. Deliv. 5(2), 149–171 (2014).
  Medline CASGoogle Scholar
• 21 Svenson S. What nanomedicine in the clinic right now really forms nanoparticles? Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 6(2), 125–135 (2014).
  Medline CASGoogle Scholar
• 22 Angelico R, Ceglie A, Sacco P, Colafemmina G, Ripoli M, Mangia A. Phyto-liposomes as nanoshuttles for water-insoluble silybin–phospholipid complex. Int. J. Pharm. 471(1–2), 173–181 (2014).
  Medline CASGoogle Scholar
• 23 Schroeder A, Turjeman K, Schroeder JE, Leibergall M, Barenholz Y. Using liposomes to target infection and inflammation induced by foreign body injuries or medical implants. Expert Opin. Drug Deliv. 7(10), 1175–1189 (2010).
  Medline CASGoogle Scholar
• 24 El Maghraby GM, Barry BW, Williams AC. Liposomes and skin: from drug delivery to model membranes. Eur. J. Pharm. Sci. 34(4–5), 203–222 (2008).
  Medline CASGoogle Scholar
• 25 Ruttala H, Ko Y. Liposome encapsulated albumin-paclitaxel nanoparticle for enhanced antitumor efficacy. Pharm. Res. 32(3), 1002–1016 (2014).
  MedlineGoogle Scholar
• 26 Lee S, Koo H, Na JH et al. DNA amplification in neutral liposomes for safe and efficient gene delivery. ACS Nano 8(5), 4257–4267 (2014).
  Medline CASGoogle Scholar
• 27 Goren D, Horowitz AT, Zalipsky S, Woodle MC, Yarden Y, Gabizon A. Targeting of stealth liposomes to ERBB-2 (HER/2) receptor: in vitro and in vivo studies. Br. J. Cancer 74(11), 1749–1756 (1996).
  Medline CASGoogle Scholar
• 28 Marqués-Gallego P, De Kroon AIPM. Ligation strategies for targeting liposomal nanocarriers. BioMed Res. Int. 2014, 12 (2014).
  Google Scholar
• 29 Brown S, Khan DR. The treatment of breast cancer using liposome technology. J. Drug Deliv. 2012, 6 (2012).
  Google Scholar
• 30 Du J, Tang Y, Lewis AL, Armes SP. pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer. J. Am. Chem. Soc. 127(51), 17982–17983 (2005).
  Medline CASGoogle Scholar
• 31 Smart TP, Mykhaylyk OO, Ryan AJ, Battaglia G. Polymersomes hydrophilic brush scaling relations. Abstr. Pap. Am. Chem. S 5, 3607–3610 (2009).
  CASGoogle Scholar
• 32 Holowka EP, Pochan DJ, Deming TJ. Charged polypeptide vesicles with controllable diameter. J. Am. Chem. Soc. 127(35), 12423–12428 (2005).
  Medline CASGoogle Scholar
• 33 Koide A, Kishimura A, Osada K, Jang W-D, Yamasaki Y, Kataoka K. Semipermeable polymer vesicle (PICsome) self-assembled in aqueous medium from a pair of oppositely charged block copolymers: physiologically stable micro-/nanocontainers of water-soluble macromolecules. J. Am. Chem. Soc. 128(18), 5988–5989 (2006).
  Medline CASGoogle Scholar
• 34 Al-Jamal WT, Kostarelos K. Liposomes: from a clinically established drug delivery system to a nanoparticle platform for theranostic nanomedicine. Acc. Chem. Res. 44(10), 1094–1104 (2011).
  Medline CASGoogle Scholar
• 35 Elnaggar YSR, El-Refaie WM, El-Massik MA, Abdallah OY. Lecithin-based nanostructured gels for skin delivery: an update on state of art and recent applications. J. Control. Release 180, 10–24 (2014).
  Medline CASGoogle Scholar
• 36 Levine DH, Ghoroghchian PP, Freudenberg J et al. Polymersomes: a new multi-functional tool for cancer diagnosis and therapy. Methods 46(1), 25–32 (2008).
  Medline CASGoogle Scholar
• 37 Discher DE, Eisenberg A. Polymer vesicles. Science 297(5583), 967–973 (2002).
  Medline CASGoogle Scholar
• 38 Discher DE, Ahmed F. Polymersomes. Annu. Rev. Biomed. Eng. 8, 323–341 (2006).
  Medline CASGoogle Scholar
• 39 Discher BM. Polymersomes: tough vesicles made from diblock copolymers. Science 284(5417), 1143–1146 (1999).•• The first ever report on polymersomes directing the development of synthetic thin-shelled capsules based on block copolymers.
  Medline CASGoogle Scholar
• 40 Peer D. Harnessing RNAi nanomedicine for precision therapy. Mol. Cell. Ther. 2(5), doi:10.1186/2052-8426-2-5 (2014) (Epub ahead of print).
  MedlineGoogle Scholar
• 41 Israelachvili JN. Intermolecular and Surface Forces (3rd Edition). Academic Press, MA, USA (2011).
  Google Scholar
• 42 Smart T, Lomas H, Massignani M, Flores-Merino MV, Perez LR, Battaglia G. Block copolymer nanostructures. Nano Today 3(3–4), 38–46 (2008).
  CASGoogle Scholar
• 43 Christian DA, Cai S, Bowen DM, Kim Y, Pajerowski JD, Discher DE. Polymersome carriers: from self-assembly to siRNA and protein therapeutics. Eur. J. Pharm. Biopharm. 71(3), 463–474 (2009).
  Medline CASGoogle Scholar
• 44 Kim S-H, Shum HC, Kim JW, Cho J-C, Weitz DA. Multiple polymersomes for programmed release of multiple components. J. Am. Chem. Soc. 133(38), 15165–15171 (2011).
  Medline CASGoogle Scholar
• 45 Marguet M, Edembe L, Lecommandoux S. Polymersomes in polymersomes: multiple loading and permeability control. Angew. Chem. Int. Ed. Engl. 51(5), 1173–1176 (2012).
  Medline CASGoogle Scholar
• 46 Battaglia G, Tomas S, Ryan AJ. Lamellarsomes: metastable polymeric multilamellar aggregates. Abstr. Pap. Am. Chem. S 3(4), 470–475 (2007).
  CASGoogle Scholar
• 47 Battaglia G, Ryan AJ. Bilayers and interdigitation in block copolymer vesicles. J. Am. Chem. Soc. 127(24), 8757–8764 (2005).
  Medline CASGoogle Scholar
• 48 Kim KT, Zhu J, Meeuwissen SA et al. Polymersome stomatocytes: controlled shape transformation in polymer vesicles. J. Am. Chem. Soc. 132(36), 12522–12524 (2010).
  Medline CASGoogle Scholar
• 49 Massignani M, Lopresti C, Blanazs A et al. Controlling cellular uptake by surface chemistry, size, and surface topology at the nanoscale. Small 5(21), 2424–2432 (2009).
  Medline CASGoogle Scholar
• 50 Sumeet J, Frank S B. On the origins of morphological complexity in block copolymer surfactants. Science 300(5618), 460–464 (2003).
  MedlineGoogle Scholar
• 51 Photos PJ, Bacakova L, Discher B, Bates FS, Discher DE. Polymer vesicles in vivo: correlations with PEG molecular weight. J. Control. Release 90(3), 323–334 (2003).•• Describes a twofold increase in in vivo circulation time of PEGylated polymersomes compared with PEGylated liposomes.
  Medline CASGoogle Scholar
• 52 Du J, Armes SP. pH-responsive vesicles based on a hydrolytically self-cross-linkable copolymer. J. Am. Chem. Soc. 127(37), 12800–12801 (2005).
  Medline CASGoogle Scholar
• 53 Bi H, Yang B, Wang L, Cao W, Han X. Electroformation of giant unilamellar vesicles using interdigitated ITO electrodes. J. Mater. Chem. A 1(24), 7125–7130 (2013).
  CASGoogle Scholar
• 54 Mabrouk E, Cuvelier D, Pontani L-L et al. Formation and material properties of giant liquid crystal polymersomes. Abstr. Pap. Am. Chem. S 5(9), 1870–1878 (2009).
  CASGoogle Scholar
• 55 Howse JR, Jones RaL, Battaglia G, Ducker RE, Leggett GJ, Ryan AJ. Templated formation of giant polymer vesicles with controlled size distributions. Nat. Mater. 8(6), 507–511 (2009).
  Medline CASGoogle Scholar
• 56 Abbaspourrad A, Duncanson WJ, Lebedeva N et al. Microfluidic fabrication of stable gas-filled microcapsules for acoustic contrast enhancement. Langmuir 29(40), 12352–12357 (2013).
  Medline CASGoogle Scholar
• 57 Liu D, Herranz-Blanco B, Mäkilä E et al. Microfluidic templated mesoporous silicon–solid lipid microcomposites for sustained drug delivery. ACS Appl. Mater. Interfaces 5(22), 12127–12134 (2013).
  Medline CASGoogle Scholar
• 58 Thiele J, Abate AR, Shum HC, Bachtler S, Förster S, Weitz DA. Fabrication of polymersomes using double-emulsion templates in glass-coated stamped microfluidic devices. Small 6(16), 1723–1727 (2010).
  Medline CASGoogle Scholar
• 59 Arriaga LR, Datta SS, Kim S-H et al. Ultrathin shell double emulsion templated giant unilamellar lipid vesicles with controlled microdomain formation. Small 10(5), 950–956 (2013).
  MedlineGoogle Scholar
• 60 Utada AS, Lorenceau E, Link DR, Kaplan PD, Stone HA, Weitz DA. Monodisperse double emulsions generated from a microcapillary device. Science 308(5721), 537–541 (2005).
  Medline CASGoogle Scholar
• 61 Marguet M, Bonduelle C, Lecommandoux S. Multicompartmentalized polymeric systems: towards biomimetic cellular structure and function. Chem. Soc. Rev. 42(2), 512–529 (2013).• A review that introduced another possiblity of polymersome-based nanoparticles in biomedical applications.
  Medline CASGoogle Scholar
• 62 Lee JC, Bermudez H, Discher BM et al. Preparation, stability, and in vitro performance of vesicles made with diblock copolymers. Biotechnol. Bioeng. 73(2), 135–145 (2001).
  Medline CASGoogle Scholar
• 63 Battaglia G, Ryan AJ. Pathways of polymeric vesicle formation. J. Phys. Chem. 110(21), 10272–10279 (2006).•• Describes the conformation changes along with the energy changes from bulk film to final vesicles upon the hydration.
  CASGoogle Scholar
• 64 Lopresti C, Massignani M, Fernyhough C et al. Controlling polymersome surface topology at the nanoscale by membrane confined polymerpolymer phase separation. ACS Nano 5(3), 1775–1784 (2011).
  Medline CASGoogle Scholar
• 65 Pearson RT, Warren NJ, Lewis AL, Armes SP, Battaglia G. Effect of pH and temperature on PMPC–PDPA copolymer self-assembly. Macromolecules 46(4), 1400–1407 (2013).
  CASGoogle Scholar
• 66 Robertson JD, Yealland G, Avila-Olias M et al. pH-sensitive tubular polymersomes: formation and applications in cellular delivery. ACS Nano 8(5), 4650–4661 (2014).
  Medline CASGoogle Scholar
• 67 Grumelard J, Taubert A, Meier W. Soft nanotubes from amphiphilic ABA triblock macromonomers. Chem. Commun. (13), 1462–1463 (2004).
  MedlineGoogle Scholar
• 68 Van Oers MCM, Rutjes FPJT, Van Hest JCM. Tubular polymersomes: a cross-linker-induced shape transformation. J. Am. Chem. Soc. 135(44), 16308–16311 (2013).
  Medline CASGoogle Scholar
• 69 Haluska C, Góźdź W, Döbereiner H-G, Förster S, Gompper G. Giant hexagonal superstructures in diblock-copolymer membranes. Phys. Rev. Lett. 89(23), 238302 (2002).
  MedlineGoogle Scholar
• 70 Christian DA, Ellenbroek WG, Tian A et al. Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding. Nat. Mater. 8(10), 843–849 (2009).
  Medline CASGoogle Scholar
• 71 Meeuwissen SA, Bruekers SMC, Chen Y, Pochan DJ, Van Hest JCM. Spontaneous shape changes in polymersomes via polymer/polymer segregation. Polymer Chemistry 5(2), 489–501 (2014).
  CASGoogle Scholar
• 72 Baumgart T, Hess ST, Webb WW. Imaging coexisting fluid domains in biomembrane models coupling curvature and line tension. Nature 425(6960), 821–824 (2003).
  Medline CASGoogle Scholar
• 73 Wang L, Chierico L, Little D et al. Encapsulation of biomacromolecules within polymersomes by electroporation. Angew. Chem. Int. Ed. Engl. 51(44), 11122–11125 (2012).
  Medline CASGoogle Scholar
• 74 Lee JS, Feijen J. Polymersomes for drug delivery: design, formation and characterization. J. Control. Release 161(2), 473–483 (2012).
  Medline CASGoogle Scholar
• 75 Jiang W, Zhou Y, Yan D. Hyperbranched polymer vesicles: from self-assembly, characterization, mechanisms, and properties to applications. Chem. Soc. Rev. 44, 3874–3889 (2015).
  Medline CASGoogle Scholar
• 76 Lomas H, Du J, Canton I et al. Efficient encapsulation of plasmid DNA in pH-sensitive PMPC-PDPA polymersomes: study of the effect of PDPA block length on copolymer-DNA binding affinity. Macromol. Biosci. 10(5), 513–530 (2010).
  Medline CASGoogle Scholar
• 77 Borchert U, Lipprandt U, Bilang M et al. pH-induced release from P2VP-PEO block copolymer vesicles. Langmuir 22(13), 5843–5847 (2006).
  Medline CASGoogle Scholar
• 78 Fernyhough C, Ryan AJ, Battaglia G. pH controlled assembly of a polybutadiene-poly(methacrylic acid) copolymer in water: packing considerations and kinetic limitations. Abstr. Pap. Am. Chem. S 5(8), 1674–1682 (2009).
  CASGoogle Scholar
• 79 Checot F, Lecommandoux S, Klok HA, Gnanou Y. From supramolecular polymersomes to stimuli-responsive nano-capsules based on poly(diene-b-peptide) diblock copolymers. Eur. Phys. J. 10(1), 25–35 (2003).
  CASGoogle Scholar
• 80 Christian NA, Milone MC, Ranka SS et al. Tat-functionalized near-infrared emissive polymersomes for dendritic cell labeling. Bioconjug. Chem. 18(1), 31–40 (2006).
  Google Scholar
• 81 Gaitzsch J, Appelhans D, Wang L, Giuseppe B, Voit B. Synthetic bionanoreactor mechanical and chemical control of polymersome membrane permeability. Angew. Chem. Int. Ed. Engl. 51(18), 4448–2251 (2012).
  Medline CASGoogle Scholar
• 82 Yu S, Azzam T, Rouiller I, Eisenberg A. “Breathing” vesicles. J. Am. Chem. Soc. 131(30), 10557–10566 (2009).
  Medline CASGoogle Scholar
• 83 Chen W, Du J. Ultrasound and pH dually responsive polymer vesicles for anticancer drug delivery. Sci. Rep. 3, 2162 (2013).
  MedlineGoogle Scholar
• 84 Massignani M, Canton I, Sun T et al. Enhanced fluorescence imaging of live cells by effective cytosolic delivery of probes. PLoS ONE 5(5), e10459 (2010).
  MedlineGoogle Scholar
• 85 Du J, O'reilly RK. Advances and challenges in smart and functional polymer vesicles. Abstr. Pap. Am. Chem. S 5(19), 3544 (2009).
  CASGoogle Scholar
• 86 Xia Y, Yin X, Burke NaD, Stöver HDH. Thermal response of narrow-disperse poly(N-isopropylacrylamide) prepared by atom transfer radical polymerization. Macromolecules 38(14), 5937–5943 (2005).
  CASGoogle Scholar
• 87 Xia Y, Burke NaD, Stöver HDH. End group effect on the thermal response of narrow-disperse poly(N-isopropylacrylamide) prepared by atom transfer radical polymerization. Macromolecules 39(6), 2275–2283 (2006).
  CASGoogle Scholar
• 88 Qin S, Geng Y, Discher DE, Yang S. Temperature-controlled assembly and release from polymer vesicles of poly(ethylene oxide)-block- poly(N-isopropylacrylamide). Adv. Mater. 18(21), 2905–2909 (2006).
  CASGoogle Scholar
• 89 Li Y, Lokitz BS, Mccormick CL. Thermally responsive vesicles and their structural “locking” through polyelectrolyte complex formation. Angew. Chem. Int. Ed. Engl. 118(35), 5924–5927 (2006).
  Google Scholar
• 90 Pasparakis G, Alexander C. Sweet talking double hydrophilic block copolymer vesicles. Angew. Chem. Int. Ed. Engl. 47(26), 4847–4850 (2008).
  Medline CASGoogle Scholar
• 91 Weaver JVM, Armes SP, Butun V. Synthesis and aqueous solution properties of a well-defined thermo-responsive schizophrenic diblock copolymer. Chem. Commun. (18), 2122–2123 (2002).
  MedlineGoogle Scholar
• 92 Weaver J, Bannister I, Robinson K et al. Stimulus-responsive water-soluble polymers based on 2-hydroxyethyl methacrylate. Macromolecules 37(7), 2395–2403 (2004).
  CASGoogle Scholar
• 93 Zou YQ, Brooks DE, Kizhakkedathu JN. A novel functional polymer with tunable LCST. Macromolecules 41(14), 5393–5405 (2008).
  CASGoogle Scholar
• 94 Meng F, Engbers GHM, Feijen J. Biodegradable polymersomes as a basis for artificial cells: encapsulation, release and targeting. J. Control. Release 101(1–3), 187–198 (2005).
  Medline CASGoogle Scholar
• 95 Meng F, Hiemstra C, Engbers GHM, Feijen J. Biodegradable polymersomes. Macromolecules 36, 3004–3006 (2003).
  CASGoogle Scholar
• 96 Meng F, Zhong Z, Feijen J. Stimuli-responsive polymersomes for programmed drug delivery. Biomacromolecules 10(2), 197–209 (2009).
  Medline CASGoogle Scholar
• 97 Li M-H, Keller P. Stimuli-responsive polymer vesicles. Abstr. Pap. Am. Chem. S 5(5), 927 (2009).
  CASGoogle Scholar
• 98 Jain JP, Kumar N. Self assembly of amphiphilic (PEG)3-PLA copolymer as polymersomes- preparation, characterization, and their evaluation as drug carrier. Biomacromolecules 11, 9 (2010).
  Google Scholar
• 99 Jain JP, Kumar N. Development of amphotericin B loaded polymersomes based on (PEG)(3)-PLA co-polymers: factors affecting size and in vitro evaluation. Eur. J. Pharm. Sci. 40(5), 456–465 (2010).
  Medline CASGoogle Scholar
• 100 Ayen WY, Garkhal K, Kumar N. Doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes: effect of solvents and process parameters on formulation development and in vitro study. Mol. Pharm. 8(2), 466–478 (2011).
  Medline CASGoogle Scholar
• 101 Ghoroghchian PP, Li G, Levine DH et al. Bioresorbable vesicles formed through spontaneous self-assembly of amphiphilic poly(ethylene oxide)-block-polycaprolactone. Macromolecules 39(5), 1673–1675 (2006).
  Medline CASGoogle Scholar
• 102 Ahmed F, Discher DE. Self-porating polymersomes of PEG–PLA and PEG–PCL: hydrolysis-triggered controlled release vesicles. J. Control. Release 96(1), 37–53 (2004).
  Medline CASGoogle Scholar
• 103 Ahmed F, Pakunlu RI, Brannan A, Bates F, Minko T, Discher DE. Biodegradable polymersomes loaded with both paclitaxel and doxorubicin permeate and shrink tumors, inducing apoptosis in proportion to accumulated drug. J. Control. Release 116(2), 150–158 (2006).
  Medline CASGoogle Scholar
• 104 Chen W, Meng F, Cheng R, Zhong Z. pH-sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles. J. Control. Release 142(1), 40–46 (2010).
  Medline CASGoogle Scholar
• 105 Kim J-K, Garripelli VK, Jeong U-H, Park J-S, Repka MA, Jo S. Novel pH-sensitive polyacetal-based block copolymers for controlled drug delivery. Int. J. Pharm. 401(1–2), 79–86 (2010).
  Medline CASGoogle Scholar
• 106 Napoli A, Valentini M, Tirelli N, Muller M, Hubbell JA. Oxidation-responsive polymeric vesicles. Nat. Mater. 3(3), 183–189 (2004).
  Medline CASGoogle Scholar
• 107 Cerritelli S, Velluto D, Hubbell JA. PEG-SS-PPS: reduction-sensitive disulfide block copolymer vesicles for intracellular drug delivery. Biomacromolecules 8(6), 1966–1972 (2007).
  Medline CASGoogle Scholar
• 108 Cabane E, Malinova V, Menon S, Palivan CG, Meier W. Photoresponsive polymersomes as smart, triggerable nanocarriers. Abstr. Pap. Am. Chem. S 7(19), 9167 (2011).
  CASGoogle Scholar
• 109 Mabrouk E, Cuvelier D, Brochard-Wyart F, Nassoy P, Li M-H. Bursting of sensitive polymersomes induced by curling. Proc. Natl Acad. Sci. USA 106(18), 7294–7298 (2009).
  Medline CASGoogle Scholar
• 110 Tong X, Wang G, Soldera A, Zhao U. How can azobenzene block copolymer vesicles be dissociated and reformed by light. J. Phys. Chem. B 109(43), 20281–20287 (2005).
  Medline CASGoogle Scholar
• 111 Wang G, Tong X, Zhao Y. Preparation of azobenzene-containing amphiphilic diblock copolymers for light-responsive micellar aggregates. Macromolecules 37(24), 8911–8917 (2004).
  CASGoogle Scholar
• 112 Cambre JN, Sumerlin BS. Biomedical applications of boronic acid polymers. Polymer 52(21), 4631–4643 (2011).
  CASGoogle Scholar
• 113 Cheng F, Jäkle F. Boron-containing polymers as versatile building blocks for functional nanostrctured materials. Polymer Chemistrty 2(10), 2122–2132 (2011).
  CASGoogle Scholar
• 114 Kim H, Kang YJ, Kang S, Kim KT. Monosaccharide-responsive release of insulin from polymersomes of polyboroxole block copolymers at neutral pH. J. Am. Chem. Soc. 134(9), 4030–4033 (2012).
  Medline CASGoogle Scholar
• 115 Kratz F, Elsadek B. Clinical impact of serum proteins on drug delivery. J. Control. Release 161(2), 429–445 (2012).•• A very recent review navigating the stealthiness of nanoparticles, conferred by their physicochemical properties and their advantages in cancer therapy.
  Medline CASGoogle Scholar
• 116 Mosqueira VCF, Legrand P, Gulik A et al. Relationship between complement activation, cellular uptake and surface physicochemical aspects of novel PEG-modified nanocapsules. Biomaterials 22(22), 2967–2979 (2001).
  Medline CASGoogle Scholar
• 117 Oltra NS, Nair P, Discher DE. From stealthy polymersomes and filomicelles to “self” peptide-nanoparticles for cancer therapy. Annu. Rev. Chem. Biomol. Eng. 5, 281–299 (2014).
  Medline CASGoogle Scholar
• 118 Diciccio JE, Steinberg BE. Lysosomal pH and ana­lysis of the counter ion pathways that support acidification. J. Gen. Physiol. 137(4), 385–390 (2011).
  Medline CASGoogle Scholar
• 119 Mellman I, Fuchs R, Helenius A. Acidification of the endocytic and exocytic pathways. Annu. Rev. Biochem. 55, 663–700 (1986).•• Presents how the size, shape and surface chemistry of nanoparticles control their cell entry via endocytosis, as well as how to escape the lysosomal degradation to achieve effective payload release.
  Medline CASGoogle Scholar
• 120 Saftig P, Klumperman J. Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function. Nat. Rev. Mol. Cell Biol. 10(9), 623–635 (2009).
  Medline CASGoogle Scholar
• 121 Canton I, Battaglia G. Endocytosis at the nanoscale. Chem. Soc. Rev. 41(7), 2718 (2012).
  Medline CASGoogle Scholar
• 122 Rejman J, Oberle V, Zuhorn IS, Hoekstra D. Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis. Biochem. J. 377(Pt 1), 159–169 (2004).
  Medline CASGoogle Scholar
• 123 Pourtau L, Oliveira H, Thevenot J et al. Antibody-functionalized magnetic polymersomes: In vivo targeting and imaging of bone metastases using high resolution MRI. Adv. Healthc. Mater. 2(11), 1420–1424 (2013).
  Medline CASGoogle Scholar
• 124 Shcherbakova DM, Verkhusha VV. Near-infrared fluorescent proteins for multicolor in vivo imaging. Nat. Methods 10(8), 751–754 (2013).
  Medline CASGoogle Scholar
• 125 Filonov GS, Piatkevich KD, Ting L-M, Zhang J, Kim K, Verkhusha VV. Bright and stable near-infrared fluorescent protein for in vivo imaging. Nat. Biotechnol. 29(8), 757–761 (2011).
  Medline CASGoogle Scholar
• 126 Frangioni JV. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol. 7(5), 626–634 (2003).
  Medline CASGoogle Scholar
• 127 Chance B. Near-infrared images using continuous, phase-modulated, and pulsed light with quantitation of blood and blood oxygenationa. Ann. NY Acad. Sci. 838(1), 29–45 (1998).
  Medline CASGoogle Scholar
• 128 Ghoroghchian PP, Frail PR, Susumu K et al. Near-infrared-emissive polymersomes: self-assembled soft matter for in vivo optical imaging. Proc. Natl Acad. Sci. USA 102(8), 2922–2927 (2005).
  Medline CASGoogle Scholar
• 129 Lin VS, DiMagno SG, Therien MJ. Highly conjugated, acetylenyl bridged porphyrins: new models for light-harvesting antenna systems. Science 264(5162), 7 (1994).
  Google Scholar
• 130 Susumu K, Therien MJ. Decoupling optical and potentiometric band gaps in π-conjugated materials. J. Am. Chem. Soc. 124(29), 8550–8552 (2002).
  Medline CASGoogle Scholar
• 131 Rubtsov IV, Susumu K, Rubtsov GI, Therien MJ. Ultrafast singlet excited-state polarization in electronically asymmetric ethyne-bridged bis[(porphinato)zinc(II)] complexes. J. Am. Chem. Soc. 125(9), 2687–2696 (2003).
  Medline CASGoogle Scholar
• 132 Bleul R, Thiermann R, Marten GU et al. Continuously manufactured magnetic polymersomes – a versatile tool (not only) for targeted cancer therapy. Nanoscale 5(23), 11385 (2013).
  Medline CASGoogle Scholar
• 133 Sanson C, Diou O, Thévenot J et al. Doxorubicin loaded magnetic polymersomes: theranostic nanocarriers for MR imaging and magneto-chemotherapy. ACS Nano 5(2), 1122–1140 (2011).
  Medline CASGoogle Scholar
• 134 Cheng Z, Tsourkas A. Paramagnetic porous polymersomes. Langmuir 24(15), 8169–8173 (2008).
  Medline CASGoogle Scholar
• 135 Chiang W-H, Huang W-C, Chang C-W et al. Functionalized polymersomes with outlayered polyelectrolyte gels for potential tumor-targeted delivery of multimodal therapies and MR imaging. J. Control. Release 168(3), 280–288 (2013).
  Medline CASGoogle Scholar
• 136 Qi W, Ghoroghchian PP, Li G, Hammer DA, Therien MJ. Aqueous self-assembly of poly(ethylene oxide)-block-poly(epsilon-caprolactone) (PEO-b-PCL) copolymers: disparate diblock copolymer compositions give rise to nano- and meso-scale bilayered vesicles. Nanoscale 5(22), 10908–10915 (2013).
  Medline CASGoogle Scholar
• 137 Hu C-MJ, Aryal S, Zhang L. Nanoparticle-assisted combination therapies for effective cancer treatment. Ther. Deliv. 1(2), 323–334 (2010).
  Medline CASGoogle Scholar
• 138 Baumann BC, Kao GD, Mahmud A et al. Enhancing the efficacy of drug-loaded nanocarriers against brain tumors by targeted radiation therapy. Oncotarget 4(1), 64–79 (2012).
  Google Scholar
• 139 Mohan P, Rapoport N. Doxorubicin as a molecular nanotheranostic agent: effect of doxorubicin encapsulation in micelles or nanoemulsions on the ultrasound-mediated intracellular delivery and nuclear trafficking. Mol. Pharm. 7(6), 1959–1973 (2010).
  Medline CASGoogle Scholar
• 140 Gustafson DL, Merz AL, Long ME. Pharmacokinetics of combined doxorubicin and paclitaxel in mice. Cancer Lett. 220(2), 161–169 (2005).
  Medline CASGoogle Scholar
• 141 Briasoulis E, Karavasilis V, Tzamakou E et al. Interaction pharmacokinetics of PEGylated liposomal doxorubicin (Caelyx) on coadministration with paclitaxel or docetaxel. Cancer Chemother. Pharmacol. 53(5), 452–457 (2004).
  Medline CASGoogle Scholar
• 142 Kim H-O, Kim E, An Y et al. A biodegradable polymersome containing Bcl-xL siRNA and doxorubicin as a dual delivery vehicle for a synergistic anticancer effect. Macromol. Biosci. 13(6), 745–754 (2013).
  Medline CASGoogle Scholar
• 143 Doherty JK, Bond C, Jardim A, Adelman JP, Clinton GM. The HER-2/neu receptor tyrosine kinase gene encodes a secreted autoinhibitor. Proc. Natl Acad. Sci. USA 96(19), 10869–10874 (1999).
  Medline CASGoogle Scholar
• 144 Sugahara KN, Teesalu T, Karmali PP et al. Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs. Science 328(5981), 1031–1035 (2010).
  Medline CASGoogle Scholar
• 145 Pang Z, Gao H, Yu Y et al. Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin. Bioconjug. Chem. 22(6), 1171–1180 (2011).
  Medline CASGoogle Scholar
• 146 Petersen MA, Hillmyer MA, Kokkoli E. Bioresorbable polymersomes for targeted delivery of cisplatin. Bioconjug. Chem. 24(4), 533–543 (2013).
  Medline CASGoogle Scholar
• 147 Lomas H, Johnston AP, Such GK et al. Polymersome-loaded capsules for controlled release of DNA. Small 7(14), 2109–2119 (2011).
  Medline CASGoogle Scholar
• 148 Pangburn TO, Georgiou K, Bates FS, Kokkoli E. Targeted polymersome delivery of siRNA induces cell death of breast cancer cells dependent upon Orai3 protein expression. Langmuir 28(35), 12816–12830 (2012).
  Medline CASGoogle Scholar
• 149 Kim Y, Tewari M, Pajerowski JD et al. Polymersome delivery of siRNA and antisense oligonucleotides. J. Control. Release 134(2), 132–140 (2009).
  Medline CASGoogle Scholar
• 150 Zhang J, Wu L, Meng F et al. pH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery. Langmuir 28(4), 2056–2065 (2012).
  Medline CASGoogle Scholar
• 151 Pang Z, Feng L, Hua R et al. Lactoferrin-conjugated biodegradable polymersome holding doxorubicin and tetrandrine for chemotherapy of glioma rats. Mol. Pharm. 7(6), 1995–2005 (2010).• Describes an excellent example of how to evaluate the in vivo safety of polymersomes.
  Medline CASGoogle Scholar
• 152 Murdoch C, Reeves KJ, Hearnden V et al. Internalization and biodistribution of polymersomes into oral squamous cell carcinoma cells in vitro and in vivo. Nanomedicine 5(7), 12 (2010).
  Google Scholar
• 153 Liu G, Ma S, Li S et al. The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes. Biomaterials 31(29), 7575–7585 (2010).
  Medline CASGoogle Scholar
• 154 Discher DE, Ortiz V, Srinivas G et al. Emerging applications of polymersomes in delivery: from molecular dynamics to shrinkage of tumors. Prog. Polym. Sci. 32(8–9), 838–857 (2007).
  Medline CASGoogle Scholar
• 155 Liu LF, Desai SD, Li T-K, Mao Y, Sun MEI, Sim S-P. Mechanism of action of camptothecin. Ann. NY Acad. Sci. 922(1), 1–10 (2000).
  Medline CASGoogle Scholar
• 156 Bleul R, Thiermann R, K S, Häfeli UO, Maskos M. Multifunctional nanocarriers for biomedical applications. Proc. SPIE 8595, 85951N (2013).
  Google Scholar
• 157 Van De Wiele C, Phonteyne P, Pauwels P et al. Gastrin-releasing peptide receptor imaging in human breast carcinoma versus immunohistochemistry. J. Nucl. Med. 49(2), 260–264 (2008).
  MedlineGoogle Scholar
• 158 Markwalder R, Reubi JC. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer Res. 59(5), 1152–1159 (1999).
  Medline CASGoogle Scholar
• 159 Friedmann T, Roblin R. Gene therapy for human genetic disease? Science 175(4025), 949–955 (1972).
  Medline CASGoogle Scholar
• 160 Miller AD. Human gene therapy comes of age. Nature 357(6378), 455–460 (1992).
  Medline CASGoogle Scholar
• 161 Nielsen C. Human gene therapy. Nature 392(6679), 6 (1998).
  MedlineGoogle Scholar
• 162 Dias N, Stein CA. Antisense oligonucleotides: basic concepts and mechanisms. Mol. Cancer Ther. 1(5), 347–355 (2002).
  Medline CASGoogle Scholar
• 163 Hannon GJ. RNA interference. Nature 418(6894), 244–251 (2002).
  Medline CASGoogle Scholar
• 164 Hart SL. Multifunctional nanocomplexes for gene transfer and gene therapy. Cell Biol. Toxicol. 26(1), 69–81 (2010).
  Medline CASGoogle Scholar
• 165 Luo D, Saltzman WM. Synthetic DNA delivery systems. Nature 18(1), 33–37 (2000).
  CASGoogle Scholar
• 166 Glover DJ, Lipps HJ, Jans DA. Towards safe, non-viral therapeutic gene expression in humans. Nat. Rev. Genet. 6(4), 299–310 (2005).
  Medline CASGoogle Scholar
• 167 Pathak A, Patnaik S, Gupta KC. Recent trends in non-viral vector-mediated gene delivery. Biotechnol. J. 4(11), 1559–1572 (2009).
  Medline CASGoogle Scholar
• 168 Huang Z, Teng W, Liu L, Wang L, Wang Q, Dong Y. Efficient cytosolic delivery mediated by polymersomes facilely prepared from a degradable, amphiphilic, and amphoteric copolymer. Nanotechnology 24(26), 265104 (2013).
  MedlineGoogle Scholar
• 169 Brown MD, Gray AI, Tetley L et al. In vitro and in vivo gene transfer with poly(amino acid) vesicles. J. Control. Release 93(2), 193–211 (2003).
  Medline CASGoogle Scholar
• 170 Brown MD, Schätzlein A, Brownlie A et al. Preliminary characterization of novel amino acid based polymeric vesicles as gene and drug delivery agents. Bioconjug. Chem. 11(6), 880–891 (2000).
  Medline CASGoogle Scholar
• 171 Lomas H, Massignani M, Abdullah KA et al. Non-cytotoxic polymer vesicles for rapid and efficient intracellular delivery. Faraday Discuss. 139, 143 (2008).
  Medline CASGoogle Scholar
• 172 Lima RT, Martins LM, Guimaraes JE, Sambade C, Vasconcelos MH. Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells. Cancer Gene Ther. 11(5), 8 (2004).
  MedlineGoogle Scholar
• 173 Egli S, Schlaad H, Bruns N, Meier W. Functionalization of block copolymer vesicle surfaces. Polymers 3(4), 252–280 (2011).
  CASGoogle Scholar
• 174 Yang X, Grailer JJ, Rowland IJ et al. Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging. ACS Nano 4(11), 6805–6817 (2010).
  Medline CASGoogle Scholar
• 175 Lu Y, Low PS. Folate-mediated delivery of macromolecular anticancer therapeutic agents. Adv. Drug Deliv. Rev. 54(5), 675–693 (2002).
  Medline CASGoogle Scholar
• 176 Wang S, Lee RJ, Cauchon G, Gorenstein DG, Low PS. Delivery of antisense oligodeoxyribonucleotides against the human epidermal growth-factor receptor into cultured Kb cells with liposomes conjugated to folate via polyethylene-glycol. Proc. Natl Acad. Sci. USA 92(8), 3318–3322 (1995).
  Medline CASGoogle Scholar
• 177 Pierschbacher MD, Ruoslahti E. Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule. Nature 309, 30–33 (1984).
  Medline CASGoogle Scholar
• 178 Kokkoli E, Mardilovich A, Wedekind A, Rexeisen EL, Garg A, Craig JA. Self-assembly and applications of biomimetic and bioactive peptide-amphiphiles. Abstr. Pap. Am. Chem. S 2(12), 1015–1024 (2006).
  CASGoogle Scholar
• 179 Ellis LM. A targeted approach for antiangiogenic therapy of metastatic human colon cancer. Am. J. Surg. 69(1), 3–10 (2003).
  Google Scholar
• 180 Jayne DG, Heath RM, Dewhurst O, Scott N, Guillou PJ. Extracellular matrix proteins and chemoradiotherapy: α5β1 integrin as a predictive marker in rectal cancer. Eur. J. Surg. Oncol. 28(1), 30–36 (2002).
  Medline CASGoogle Scholar
• 181 Jia Y, Zeng Z-Z, Markwart SM et al. Integrin fibronectin receptors in matrix metalloproteinase-1-dependent invasion by breast cancer and mammary epithelial cells. Cancer Res. 64(23), 8674–8681 (2004).
  Medline CASGoogle Scholar
• 182 Chen J, De S, Brainard J, Byzova TV. Metastatic properties of prostate cancer cells are controlled by VEGF. Cell Commun. Adhes. 11(1), 1–11 (2004).
  MedlineGoogle Scholar
• 183 Maglott A, Bartik P, Cosgun S et al. The small α5β1 integrin antagonist, SJ749, reduces proliferation and clonogenicity of human astrocytoma cells. Cancer Res. 66(12), 6002–6007 (2006).
  Medline CASGoogle Scholar
• 184 Dingemans A-MC, Van Den Boogaart V, Vosse BA, Van Suylen R-J, Griffioen AW, Thijssen VL. Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer. Mol. Cancer 9(152), doi:10.1186/1476-4598-9-152 (2010) (Epub ahead of print).
  MedlineGoogle Scholar
• 185 Faouzi M, Hague F, Potier M, Ahidouch A, Sevestre H, Ouadid-Ahidouch H. Down-regulation of Orai3 arrests cell-cycle progression and induces apoptosis in breast cancer cells but not in normal breast epithelial cells. J. Cell. Physiol. 226(2), 542–551 (2011).
  Medline CASGoogle Scholar
• 186 Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C, Perez JM. Biochemical mechanisms of cisplatin cytotoxicity. Anticancer Agents Med. Chem. 7(1), 3–18 (2007).
  Medline CASGoogle Scholar
• 187 Fasanaro P, Greco S, Lorenzi M et al. An integrated approach for experimental target identification of hypoxia-induced miR-210. J. Biol. Chem. 284(50), 35134–35143 (2009).
  Medline CASGoogle Scholar
• 188 Wu H, Zhu S, Mo YY. Suppression of cell growth and invasion by miR-205 in breast cancer. Cell Res. 19(4), 439–448 (2009).
  Medline CASGoogle Scholar
• 189 Tolmachev V. Imaging of HER-2 overexpression in tumors for guiding therapy. Curr. Pharm. Des. 14(28), 2999–3019 (2008).
  Medline CASGoogle Scholar
• 190 Kumar SR, Quinn TP, Deutscher SL. Evaluation of an ¹¹¹In-radiolabeled peptide as a targeting and imaging agent for ErbB-2 receptor expressing breast carcinomas. Clin. Cancer Res. 13(20), 6070–6079 (2007).
  Medline CASGoogle Scholar
• 191 Upadhyay KK, Meins JFL, Misra A et al. Biomimetic doxorubicin loaded polymersomes from hyaluronan-block-poly(γ-benzyl glutamate) copolymers. Biomacromolecules 10(10), 2802–2808 (2009).
  Medline CASGoogle Scholar
• 192 Upadhyay KK, Bhatt AN, Castro E et al. In vitro and in vivo evaluation of docetaxel loaded biodegradable polymersomes. Macromol. Biosci. 10(5), 503–512 (2010).
  Medline CASGoogle Scholar
• 193 Girish KS, Kemparaju K. The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 80(21), 1921–1943 (2007).
  Medline CASGoogle Scholar
• 194 Rameez S, Alosta H, Palmer AF. Biocompatible and biodegradable polymersome encapsulated hemoglobin: a potential oxygen carrier. Bioconjug. Chem. 19(5), 1025–1032 (2008).
  Medline CASGoogle Scholar
• 195 Jain JP, Jatana M, Chakrabarti A, Kumar N. Amphotericin-B-loaded polymersomes formulation (PAMBO) based on (PEG)3-PLA copolymers: an in vivo evaluation in a murine model. Mol. Pharm. 8(1), 204–212 (2011).
  Medline CASGoogle Scholar
• 196 Ayen WY, Kumar N. In vivo evaluation of doxorubicin-loaded (PEG)(3)-PLA nanopolymersomes (PolyDoxSome) using DMBA-induced mammary carcinoma rat model and comparison with marketed LipoDox. Pharm. Res. 29(9), 2522–2533 (2012).
  Medline CASGoogle Scholar
• 197 Monopoli MP, Aberg C, Salvati A, Dawson KA. Biomolecular coronas provide the biological identity of nanosized materials. Nat. Nanotechnol. 7(12), 779–786 (2012).
  Medline CASGoogle Scholar
• 198 Salvati A, Pitek AS, Monopoli MP et al. Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface. Nat. Nano 8(2), 137–143 (2013).
  Medline CASGoogle Scholar
• 199 Carroll MV, Sim RB. Complement in health and disease. Adv. Drug Deliv. Rev. 63(12), 965–975 (2011).
  Medline CASGoogle Scholar
• 200 Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11(9), 785–797 (2010).
  Medline CASGoogle Scholar
• 201 Pomeroy C, Mitchell J, Eckert E, Raymond N, Crosby R, Dalmasso AP. Effect of body weight and caloric restriction on serum complement proteins, including Factor D/adipsin: studies in anorexia nervosa and obesity. Clin. Exp. Immunol. 108(3), 507–515 (1997).
  Medline CASGoogle Scholar
• 202 Macor P, Tedesco F. Complement as effector system in cancer immunotherapy. Immunol. Lett. 111(1), 6–13 (2007).
  Medline CASGoogle Scholar
• 203 Carter D, Lieber A. Protein engineering to target complement evasion in cancer. FEBS Lett. 588(2), 334–340 (2014).
  Medline CASGoogle Scholar
• 204 Danhier F, Feron O, Préat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J. Control. Release 148(2), 135–146 (2010).
  Medline CASGoogle Scholar
• 205 Choi KY, Chung H, Min KH et al. Self-assembled hyaluronic acid nanoparticles for active tumor targeting. Biomaterials 31(1), 106–114 (2010).
  Medline CASGoogle Scholar
• 206 Choi KY, Saravanakumar G, Park JH, Park K. Hyaluronic acid-based nanocarriers for intracellular targeting: interfacial interactions with proteins in cancer. Colloids Surf. B Biointerfaces 99(0), 82–94 (2012).
  Medline CASGoogle Scholar
• 207 Chandrawati R, Caruso F. Biomimetic liposome- and polymersome-based multicompartmentalized assemblies. Langmuir 28(39), 13798–13807 (2012).
  Medline CASGoogle Scholar