We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine

Nanomedicine against multidrug resistance in cancer treatment

    Jie Gao

    International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, PR China

    ,
    Si-Shen Feng

    Department of Chemical & Biomolecular Engineering, National University of Singapore, Block E5, 02–11, Engineering Drive 4, 117576, Singapore

    &
    Yajun Guo

    * Author for correspondence

    International Joint Cancer Institute, The Second Military Medical University, 800 Xiang Yin Road, Shanghai 200433, PR China.

    Published Online:https://doi.org/10.2217/nnm.12.11
    Free first page

    Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

    References

    • Dong X, Mumper RJ. Nanomedicinal strategies to treat multidrug-resistant tumors: current progress. Nanomedicine (Lond.)5,597–615 (2010).▪▪ Outstanding review of nanomedicinal strategies for multidrug resistance in cancer therapy.
    • Shapira A, Livney YD, Broxterman HJ. Nanomedicine for targeted cancer therapy: towards the overcoming of drug resistance. Drug Resist. Updat.14,150–163 (2011).▪▪ Comprehensive review reporting nanomedicines to overcome drug resistance in cancer therapy.
    • Dean M, Fojo T, Bates S. Tumor stem cells and drug resistance. Nat. Rev. Cancer5,275–284 (2005).▪▪ Excellent review article describing the relationship of cancer stem cells and drug resistance.
    • Reed JC. Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol. Oncol. Clin. North Am.9,451–473 (1995).
    • Shannon AM, Bouchier-Hayes DJ, Condron CM. Tumour hypoxia, chemotherapeutic resistance and hypoxia-related therapies. Cancer Treat. Rev.29,297–307 (2003).
    • Chen AM, Zhang M, Wei D. Co-delivery of doxorubicin and Bcl-2 siRNA by mesoporous silica nanoparticles enhances the efficacy of chemotherapy in multidrug-resistant cancer cells. Small5,2673–2677 (2009).▪ Simultaneous delivery of doxorubicin and Bcl-2 siRNA using mesoporous silica nanoparticles showed significantly enhanced antitumor activity in multidrug-resistant cancer cells.
    • Senchenkov A, Litvak DA, Cabot MC. Targeting ceramide metabolism – a strategy for overcoming drug resistance. J. Natl. Cancer Inst.93,347–357 (2001).
    • Meads MB, Gatenby RA, Dalton WS. Enviroment-mediated drug resistance: a major contributor to minimal residual disease. Nat. Rev. Cancer9,665–674 (2009).▪▪ Excellent review article regarding tumor environment and multidrug resistance.
    • Wion D, Berger F. Cancer stem cells. N. Engl. J. Med.355,1253–1261 (2006).
    • 10  Greenberg PL, Lee SJ, Advani R: Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a Phase III trial (E2995). J. Clin. Oncol.22,1078–1086 (2004).▪▪ Report about the pharmacokinetic interaction that exists between the chemotherapeutics and the ABC transporter inhibitors.
    • 11  Feng SS, Zhao LY, Tang JT. Nanomedicine for oral chemotherapy. Nanomedicine (Lond.)6(3),407–410 (2011).▪▪ Editorial for a short review on nanomedicine for oral chemotherapy in comparison with ABC transporter application.
    • 12  Gao J, Feng SS, Guo Y. Antibody engineering promotes nanomedicine for cancer treatment. Nanomedicine (Lond.)5,1141–1145 (2010).▪ Classical editorial about the contribution of antibodies to nanomedicines in cancer therapy.
    • 13  Chow EK, Zhang XQ, Chen M. Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment. Sci. Transl. Med.3,73ra21 (2011).▪▪ Excellent work about nanodiamond-delivered doxorubicin in overcoming multidrug resistance in cancer.
    • 14  Minko T, Kopeckova P, Kopecek J. Comparison of the anticancer effect of free and HPMA copolymer-bound adriamycin in human ovarian carcinoma cells. Pharm. Res.16,986–996 (1999).
    • 15  Song XR, Cai Z, Zheng Y. Reversion of multidrug resistance by coencapsulation of vincristine and verapamil in PLGA nanoparticles. Eur. J. Pharm. Sci.37,300–305 (2009).
    • 16  Ganta S, Amiji M. Coadministration of paclitaxel and curcumin in nanoemulsion formulations to overcome multidrug resistance in tumor cells. Mol. Pharm.6,928–939 (2009).
    • 17  Tseng YC, Mozumdar S, Huang L. Lipid-based systemic delivery of siRNA. Adv. Drug Deliv. Rev.61,721–731 (2009).
    • 18  Gao J, Yu Y, Zhang Y. EGFR-specific PEGylated immunoliposomes for active siRNA delivery in hepatocellular carcinoma. Biomaterials33,270–282 (2012).▪▪ Excellent work regarding EGF receptor-specific immunoliposomes for siRNA-mediated gene silencing in hepatocellular carcinoma.
    • 19  Gao J, Liu W, Xia Y. The promotion of siRNA delivery to breast cancer overexpressing epidermal growth factor receptor through anti-EGFR antibody conjugation by immunoliposomes. Biomaterials32,3459–3470 (2011).
    • 20  Yadav S, van Vlerken LE, Little SR. Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells. Cancer Chemother. Pharmacol.63,711–722 (2009).