Review

Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles

Graduate School of Pure & Applied Sciences, University of Tsukuba. 1–1-1 Ten-noudai, Tsukuba, Ibaraki 305–8573, Japan

† Author for correspondence

International Center for Materials Nanoarchitectonics Satellite (MANA), National Institute for Materials Science (NIMS) & University of Tsukuba.

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Email the corresponding author at yukio@nagalabo.jp

Published Online:27 Sep 2010https://doi.org/10.2217/nnm.10.76

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Abstract

RNA interference is a post-transcriptional gene-silencing pathway induced by double-stranded small interfering RNA (siRNA). The potential use of siRNA as a therapeutic agent has attracted great attention as a novel approach to the treatment of several intractable diseases. Despite the rapid progress in the therapeutic use of siRNA, systemic application is still controversial due to the limitations of siRNA, such as low enzymatic tolerability, cellular internalization and body distribution after systemic administration. This review describes the recent progress and strategies of siRNA delivery systems based on polyion complexes. Numerous siRNA-containing polyion complex systems bound together through electrostatic interactions between the negatively charged siRNA and positively charged components, including synthetic polymers, biopolymers and nanoparticles, have been developed for the therapeutic application of siRNA. Additionally, stimulus-sensitive smart siRNA carrier systems, including bioreducible polycations and hydrophilic polymer–siRNA conjugates, have been developed to enhance the gene-silencing efficacy of siRNAs.

Keywords:

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Vol. 5, No. 7
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Published online 27 September 2010

Published in print September 2010

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© Future Medicine Ltd
Keywords
Financial & competing interests disclosure
This work was financially supported by the Core Research Program for Evolutional Science and Technology (CREST) from the Japan Science and Technology Corporation (JST) and a Grant-in-Aid for Scientific Research (#18200033) from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.

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Smart siRNA delivery systems based on polymeric nanoassemblies and nanoparticles

Abstract

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