Blood clearance and tissue distribution of PEGylated and non-PEGylated gold nanorods after intravenous administration in rats

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Bibliography

• 1  Rayavarapu RG, Petersen W, Ungureanu C, Post JN, Van Leeuwen TG, Manohar S: Synthesis and bioconjugation of gold nanoparticles as potential molecular probes for light-based imaging techniques. Int. J. Biomed Imaging29817 (2007).Medline, Google Scholar
• 2  De Jong WH, Borm PJA: Drug delivery and nanoparticles: applications and hazards. Int. J. Nanomedicine3,133–149 (2008).▪ Review with focus on toxicological evaluation of nanoparticles for drug delivery.Crossref, Medline, CAS, Google Scholar
• 3  Duncan R: The dawning era of polymer therapeutics. Nat. Rev. Drug Disc.2,347–360 (2003).Crossref, Medline, CAS, Google Scholar
• 4  Ferrari M: Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer5,161–171 (2005).▪ Comprehensive overview of possibilities for use of nanomaterials for cancer treatment.Crossref, Medline, CAS, Google Scholar
• 5  Li S-D, Huang L: Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharmac.5,496–504 (2008).Crossref, Medline, CAS, Google Scholar
• 6  Alexis F, Pridgen E, Molnar LK, Farokhzad OC: Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharm.5,505–515 (2008).▪ Review dealing with factors affecting blood clearance of nanoparticles.Crossref, Medline, CAS, Google Scholar
• 7  De Jong WH, Hagens WI, Krystek P, Burger MC, Sips AJAM, Geertsma RE: Particle size dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials29,1912–1919 (2008).Crossref, Medline, CAS, Google Scholar
• 8  Demoy M, Gibaud S, Andreux JP, Weingarten C, Gouritin B, Couvreur P: Splenic trapping of nanoparticles: complementary approaches for in situ studies. Pharm. Res.14,463–468 (1997).Crossref, Medline, CAS, Google Scholar
• 9  Gibaud S, Demoy M, Andreux JP, Weingarten C, Gouritin B, Couvreur P: Cells involved in the capture of nanoparticles in hematopoietic organs. J. Pharm. Sci.85,944–950 (1996).Crossref, Medline, CAS, Google Scholar
• 10  Lenaerts V, Nagelkerke JF, Van Berkel TJ et al.: In vivo uptake of polyisobutyl cyanoacrylate nanopartuicles by rat liver Kupffer, endothelial, and parenchyma cells. J. Pharm. Sci.73,980–982 (1984).Crossref, Medline, CAS, Google Scholar
• 11  Moghimi SM, Hunter AC, Murray JC: Long circulating and target specific nanoparticles: theory and practice. Pharmacol. Rev.53,283–318 (2001).Medline, CAS, Google Scholar
• 12  Sadauskas E, Wallin H, Stoltenberg M et al.: Kupffer cells are central in the removal of nanoparticles from the organism. Part Fibre Toxicol.4,10 (2007).▪ Study clearly demonstrating localization of nanoparticles in Kupffer cells of liver.Crossref, Medline, Google Scholar
• 13  Weissenbrock A, Wirth M, Gabor F: WGA grafted PLGA-nanospheres: preparation and association with Caco-2 cells. J. Control. Release99,383–392 (2004).Crossref, Medline, Google Scholar
• 14  Nobs L, Buchegger F, Gurny R, Allémann E: Poly(lactic acid) nanoparticles labeled with biologically active Neutravidin™ for active targeting. Eur. J. Pharm. Biopharm.58,483–490 (2004).Crossref, Medline, CAS, Google Scholar
• 15  Prinzen L, Miserus R, Dirksen A et al.: Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano. Lett.7,93–100 (2007).Crossref, Medline, CAS, Google Scholar
• 16  Niidome T, Yamagata M, Okamoto Y et al.: PEG-modified gold nanorods with a stealth character for in vivo application. J. Control. Release114,343–347 (2006).Crossref, Medline, CAS, Google Scholar
• 17  Akiyama Y, Mori T, Katayama Y, Niidome T: The effects of PEG grafting level and injection dose on gold nanorod biodistribution in the tumor bearing mice. J. Control. Release139,81–84 (2009).Crossref, Medline, CAS, Google Scholar
• 18  Von Maltzahn G, Park J-H, Agrawal A et al.: Computationally guided photothermal tumor therapy using long-circulating gold nanorod antennas. Cancer Res.69,3892–3900 (2009).Crossref, Medline, CAS, Google Scholar
• 19  Eghtedari M, Liopo AV, Copland JA, Oraevsky AA, Motamedi M: Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells. Nano. Lett.9,287–291 (2009).Crossref, Medline, CAS, Google Scholar
• 20  Balogh L, Nigavekar SS, Nair BM et al.: Significant effect of size on the in vivo biodistribution of gold composite nanodevices in mouse tumor models. Nanomedicine3,281–296 (2007).Crossref, Medline, CAS, Google Scholar
• 21  Semmler-Behnke M, Kreyling WG, Lipka J et al.: Biodistribution of 1.4- and 18-nm gold particles in rats. Small4,2108–2111 (2008).Crossref, Medline, CAS, Google Scholar
• 22  Lin AWH, Lewinski NA, West JL, Halas NJ, Drezek RA: Optically tunable nanoparticle contrast agents for early cancer detection: model-based analysis of gold nanoshells. J. Biomed. Opt.10,064035 (2005).Crossref, Medline, Google Scholar
• 23  Perez-Juste J, Pastoriza-Santos I, Liz-Marzan L, Mulvaney P: Gold nanorods: synthesis, characterization and applications. Coord. Chem. Rev.249,1870–1901 (2005).Crossref, CAS, Google Scholar
• 24  Sokolov K, Follen M, Aaron J et al.: Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. Cancer Res.63,1999–2004 (2003).Medline, CAS, Google Scholar
• 25  Stuart DA, Haes AJ, Yonzon CR, Hicks EM, Van Duyne RP: Biological applications of localised surface plasmonic phenomenae. IEE Proc. Nanobiotechnol.152,13–32 (2005).Crossref, Medline, CAS, Google Scholar
• 26  Nikoobakht B, El-Sayed MA: Preparation and growth mechanism of gold nanorods (NRs) using seed-mediated growth method. Chem. Mater.15,1957–1962 (2003).Crossref, CAS, Google Scholar
• 27  Liu M, Guyot-Sionnest P: Mechanism of silver(I)-assisted growth of gold nanorods and bipyramids. J. Physic. Chem. B109,22192–22200 (2005).Crossref, Medline, CAS, Google Scholar
• 28  Takahashi H, Niidome Y, Niidome T, Kaneko K, Kawasaki H, Yamada S: Modification of gold nanorods using phosphatidylcholine to reduce cytotoxicity. Langmuir22,2–5 (2006).Crossref, Medline, CAS, Google Scholar
• 29  Alkilany AM, Nagaria PK, Hexel CR, Shaw TJ, Murphy CJ, Wyatt MD: Cellular uptake and cytotoxicity of gold nanorods: molecular origin of cytotoxicity and surface effects. Small5,701–708 (2009).Crossref, Medline, CAS, Google Scholar
• 30  Rayavarapu RG, Petersen W, Hartsuiker L et al.: In vitro toxicity studies of polymer-coated gold nanorods. Nanotechnology21, No. 145101 (2010)Crossref, Medline, Google Scholar
• 31  Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia MA, McNeil SE: Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv. Drug Del. Rev.61,428–437 (2009).▪ Review on nanoparticle–protein interaction.Crossref, Medline, CAS, Google Scholar
• 32  Dobrovolskaia MA, Patri AK, Zheng J et al.: Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles. Nanomedicine5,106–117 (2009).Crossref, Medline, CAS, Google Scholar
• 33  De Paoli Lacerda SH, Park JJ, Meuse C et al.: Interaction of gold nanoparticles with common human blood proteins. ACS Nano.4,365–379 (2010).Crossref, Medline, CAS, Google Scholar
• 34  Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA: The nanoparticle–protein complex as a biological entity; a complex fluids and surface science challenge for the 21st Century. Adv. Colloid Interface Sci.134–135, 167–174 (2007).Google Scholar
• 35  Lynch I, Dawson KA: Protein–nanoparticle interactions. Nano. Today3,40–47 (2008).Crossref, CAS, Google Scholar
• 36  Nel AE, Mädler L, Velegol D et al.: Understanding biophysicochemical interactions at the nano-bio interface. Nat. Mater.8,543–557 (2009).Crossref, Medline, CAS, Google Scholar
• 37  Liao H, Hafner JH: Gold nanorod bioconjugates. Chem. Mater.17,4636–4641 (2005).Crossref, CAS, Google Scholar
• 38  Storm G, Belliot SO, Daemen T, Lasic DD: Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system. Adv. Drug Del. Rev.17,31–48 (1995).▪ Early review on possibilities to avoid uptake of nanoparticles by phagocytic cells by surface modification.Crossref, CAS, Google Scholar
• 39  Gref R, Lück M, Quellec P et al.: ‘Stealth’ corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption. Colloids Surf. B: Biointerfaces18,301–313 (2000).Crossref, Medline, CAS, Google Scholar
• 40  Owens III DE, Peppas NA: Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm.307,93–102 (2006).▪ Review on serum protein and polymer-coated nanoparticle interaction, and influence on in vivo fate of the particles.Crossref, Medline, CAS, Google Scholar
• 41  Moghimi SM: Mechanisms of splenic clearance of blood cells and particles: towards development of new splenotropic agents. Adv. Drug Del. Rev.17,103–115 (1995).▪ The anatomy and function of the spleen as a blood filter.Crossref, CAS, Google Scholar
• 42  Sadauskas E, Danscher G, Stoltenberg M, Vogel U, Larsen A, Wallin H: Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine5,162–169 (2009).Crossref, Medline, CAS, Google Scholar
• 43  Yu LE, Yung L-YL, Ong C-N et al.: Translocation and effects of gold nanoparticles after inhalation exposure in rats. Nanotoxicology1,235–242 (2007).Crossref, CAS, Google Scholar
• 44  Xia T, Kovonich M, Liong M et al.: Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress. ACS Nano.2,2121–21334 (2008).Crossref, Medline, CAS, Google Scholar
• 45  Nemmar A, Hoet PH, Vanquickenborne B et al.: Passage of inhaled particles into the blood circulation in humans. Circulation105,411–414 (2002).▪ Study showing nanoparticle translocation form lung to blood, but debated because of loss of radiolabel.Crossref, Medline, CAS, Google Scholar
• 46  Kreyling WG, Semmler M, Moller W: Dosimetry and toxicology of ultrafine particles. J. Aerosol Med.17,140–152 (2004).Crossref, Medline, CAS, Google Scholar
• 47  Mills NL, Amin N, Robinson SD et al.: Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am. J. Respir. Crit. Care Med.173,426–431 (2006).Crossref, Medline, Google Scholar