Review

Tianjin Key Laboratory of Brain Science & Neural Engineering, Academy of Medical Engineering & Translational Medicine, Tianjin University, Tianjin, 300072, China

Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China

Xue Li

Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China

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Xiaoyu Mu

Tianjin Key Laboratory of Brain Science & Neural Engineering, Academy of Medical Engineering & Translational Medicine, Tianjin University, Tianjin, 300072, China

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Xuening Zhang

Department of Radiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China

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Hao Wang

*Author for correspondence: Tel.: +86 1375 240 3114;

E-mail Address: hao_wang@tju.edu.cn

Tianjin Key Laboratory of Brain Science & Neural Engineering, Academy of Medical Engineering & Translational Medicine, Tianjin University, Tianjin, 300072, China

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Xiao-Dong Zhang

**Author for correspondence: Tel.: +86 1375 216 8632;

E-mail Address: xiaodongzhang@tju.edu.cn

Tianjin Key Laboratory of Brain Science & Neural Engineering, Academy of Medical Engineering & Translational Medicine, Tianjin University, Tianjin, 300072, China

Department of Physics & Tianjin Key Laboratory of Low Dimensional Materials Physics & Preparing Technology, School of Sciences, Tianjin University, Tianjin, 300350, China

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Published Online:8 Dec 2022https://doi.org/10.2217/nnm-2022-0124

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Abstract

Near-infrared-II (NIR-II) fluorescence imaging has rapidly developed for the noninvasive investigation of physiological and pathological activities in living organisms with high spatiotemporal resolution. However, the penetration depth of fluorescence restricts its ability to provide deep anatomical information. Scientists integrate NIR-II fluorescence imaging with other imaging modes (such as photoacoustic and magnetic resonance imaging) to create multimodal imaging that can acquire detailed anatomical and quantitative information with deeper penetration by using multifunctional probes. This review offers a comprehensive picture of NIR-II-based dual/multimodal imaging probes and highlights advances in bioimaging and therapy. In addition, seminal studies and trends in multimodal imaging probes activated by NIR-II laser are summarized and several key points regarding future clinical translation are elucidated.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 17, No. 21

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Received 18 May 2022

Accepted 14 November 2022

Published online 8 December 2022

Published in print September 2022

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To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/nnm-2022-0124

Author contributions

M Wu wrote the draft and supervised the submittal, revision and coordination of the manuscript. X Li, X Mu and X Zhang participated in the collection of literature and revision of the manuscript. H Wang and X Zhang supervised the study design and quality assurance of the manuscript.

Financial & competing interests disclosure

This work was financially supported by the National Key Research and Development Program of China (2021YFF1200700), the National Natural Science Foundation of China (91859101, 81971744, U1932107, 82001952, 11804248, 81701826 and 81971673), Outstanding Youth Funds of Tianjin (2021FJ-0009), National Natural Science Foundation of Tianjin (19JCZDJC34000, 20JCYBJC00940, 21JCZDJC00620 and 21JCYBJC00490), the Innovation Foundation of Tianjin University and CAS Interdisciplinary Innovation Team (JCTD-2020-08), Key Program of the Tianjin Health and Family Planning Commission (16KG115) and Tianjin Health Research Project (TJWJ2021QN035 and TJMJ2022MS010). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Multimodal molecular imaging in the second near-infrared window

Abstract

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