Research Article

Prevention of abdominal adhesion by a polycaprolactone/phospholipid hybrid film containing quercetin and silver nanoparticles

Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

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Shahram Rabbani

Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular Diseases Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, 14155-6153, Iran

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Arash Mahboubi

Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

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Sayyed Abbas Tabatabai

Department of Pharmaceutical Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

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Azadeh Haeri

*Author for correspondence:

E-mail Address: a_haeri@sbmu.ac.ir

https://orcid.org/0000-0003-2234-9222

Department of Pharmaceutics & Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

Protein Technology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 14155-6153, Iran

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Published Online:21 Oct 2021https://doi.org/10.2217/nnm-2021-0209

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Abstract

Aim: To develop quercetin-loaded poly(caprolactone) (PCL)/soybean phosphatidylcholine (PC) films coated with silver (Ag) to prevent the formation of postoperative adhesions (POA). Materials & methods: Films were prepared using the solvent casting method, coated with Ag, and underwent in vitro tests. In vivo studies were conducted employing an animal model of sidewall defect and cecum abrasion. Results: Films showed sustained release behavior of quercetin and Ag. Coating films with Ag improved their antimicrobial activity. In vivo studies confirmed superior antiadhesion properties of films compared with the control groups evaluated by gross observation, histochemical staining and immunohistochemistry analyses. Conclusion: Ag-Q-PCL-PC films are a potential candidate to prevent POA by acting as a sustained release delivery system and physical barrier.

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Papers of special note have been highlighted as: • of interest

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Vol. 16, No. 27

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History

Received 1 June 2021

Accepted 27 August 2021

Published online 21 October 2021

Published in print November 2021

Information

Keywords

Author contributions

R Hosseinpour-Moghadam performed the experiments, analyzed data and wrote the manuscript. S Rabbani designed and performed the in vivo experiments and edited the manuscript. A Mahboubi supervised the antimicrobial experiments and edited the manuscript. SA Tabatabai supervised the in vitro characterization, was involved in finance acquisition and edited the manuscript. A Haeri designed the study, supervised project administration, analyzed data and edited the manuscript. All authors approved the final version of the manuscript.

Financial & competing interests disclosure

This work was supported by Shahid Beheshti University of Medical Sciences and the National Animal Modeling Network and In vivo Research, Council for Development of Stem Cell Sciences and Technologies, Vice-Presidency for Science and Technology grant no. 98/11630. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

All animal procedures were approved by the local ethics committee on animal research of Shahid Beheshti University of Medical Sciences (Tehran, Iran) and the authors have followed the principles outlined in the Declaration of Helsinki for all animal experimental investigations.

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