Research Article

PTT combination therapy

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Huilin Gou

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Yanfeng Liu

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Kai Xi

*Author for correspondence: Tel.: +86 25 89682304;

E-mail Address: xikai@nju.edu.cn

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Dechen Jiang

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Xudong Jia

**Author for correspondence: Tel.: +86 25 89683562;

E-mail Address: jiaxd@nju.edu.cn

School of Chemistry & Chemical Engineering, Nanjing University, Nanjing, 210023, PR China

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Published Online:24 Apr 2020https://doi.org/10.2217/nnm-2020-0022

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Abstract

Aim: To develop a hybrid nanoassembly platform using PEG-chitosan/iron oxide nanoparticles for effective low-power assisted photodynamic/photothermal combination therapy. Materials & methods: The hybrid nanoassemblies (NAs) were firstly fabricated by self-assembling chitosan and iron oxide nanoparticles, following which their surfaces were modified with polyethylene glycolated triphenylphosphine and loaded with methylene blue (MB) photosensitizer. The physical characteristics and phototherapy effects of these NAs were evaluated. Results: The formed MB-loaded NAs could produce both heat and singlet oxygen under low-power near-infrared irradiation, which would damage the cancer cells. Delivered by intravenous injection, the MB-loaded NAs showed high tendency to accumulate at the tumor sites, which would lead to effective cancer treatment under controlled photoexcitation without damaging the normal tissues. Conclusion: The proposed low-power assisted simultaneous photodynamic/photothermal approach effectively improves treatment efficiency and provides safe and precise treatment option.

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Vol. 15, No. 11

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History

Received 16 January 2020

Accepted 12 March 2020

Published online 24 April 2020

Published in print May 2020

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Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/nnm-2020-0022

Financial & competing interests disclosure

The work was financially supported by the Fundamental Research Funds for the Central Universities (no. 020514380149; 14380190) and the National Natural Science Foundation of China (21875102). These funding agencies were involved in the design, collection, analysis and interpretation of the data, as well as the writing and publication of the manuscripts. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human or animal experimental investigations.

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