Protective effects of nanoceria in imiquimod induced psoriasis by inhibiting the inflammatory responses

References

• 1. Sahu S , Katiyar SS , Kushwah V , Jain S . Active natural oil-based nanoemulsion containing tacrolimus for synergistic antipsoriatic efficacy. Nanomedicine 13(16), 1985–1998 (2018).
  CASGoogle Scholar
• 2. Valdimarsson H , Bake BS , Jónsdótdr I , Fry L . Psoriasis: a disease of abnormal keratinocyte proliferation induced by T lymphocytes. Immunol. Today 7(9), 256–259 (1986).
  Medline CASGoogle Scholar
• 3. Rebholz B , Haase I , Eckelt B et al. Crosstalk between keratinocytes and adaptive immune cells in an IκBα protein-mediated inflammatory disease of the skin. Immunity 27(2), 296–307 (2007).
  Medline CASGoogle Scholar
• 4. Magee C , Farkas F , Ikumi N et al. SAT0319 description of musculoskeletal symptoms in a cohort of patients with psoriasis. Ann. Reheum. Dis. 77(Suppl. 2), 1024 (2018).
  Google Scholar
• 5. El-Boghdady NA , Ismail MF , Abd-Alhameed MF , Ahmed AS , Ahmed HH . Bidirectional association between psoriasis and obesity: benefits and risks. J. Interferon Cytokine Res. 38(1), 12–19 (2018).
  Medline CASGoogle Scholar
• 6. Dattilo G , Imbalzano E , Casale M et al. Psoriasis and cardiovascular risk: correlation between psoriasis and cardiovascular functional indices. Angiology 69(1), 31–37 (2018).
  MedlineGoogle Scholar
• 7. Frers RAK , Otero-Losada M , Kersberg E , Cosentino V , Capani F . Immune system links psoriasis-mediated inflammation to cardiovascular diseases via traditional and non-traditional cardiovascular risk factors. In: An Interdisciplinary Approach to Psoriasis. Chiriac A (Ed.). InTech, London, UK (2017).
  Google Scholar
• 8. Naldi L , Chatenoud L , Linder D et al. Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: results from an Italian case–control study. J. Investig. Dermatol. 125(1), 61–67 (2005).
  Medline CASGoogle Scholar
• 9. Umezawa Y , Ozawa A , Kawasima T et al. Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch. Dermatol. Res. 295(1), S43–S54 (2003).
  MedlineGoogle Scholar
• 10. Woo SM , Choi JW , Yoon HS , Jo SJ , Youn JI . Classification of facial psoriasis based on the distributions of facial lesions. J. Am. Acad. Dermatol. 58(6), 959–963 (2008).
  MedlineGoogle Scholar
• 11. Griffiths C , Christophers E , Barker J et al. A classification of psoriasis vulgaris according to phenotype. Br. J. Dermatol. 156(2), 258–262 (2007).
  Medline CASGoogle Scholar
• 12. Sukarovska BG , Lipozencić J , Vrzogić P . Topical corticosteroids and corticosteroid sparing therapy in psoriasis management. Acta Med. Croatica 61(4), 375–381 (2007).
  MedlineGoogle Scholar
• 13. Brown KL , Krejci-Manwaring J , Tusa MG et al. Poor compliance with topical corticosteroids for atopic dermatitis despite severe disease. Dermatol. Online J. 14(9), (2008).
  Google Scholar
• 14. Kyosseva SV , Chen L , Seal S , McGinnis JF . Nanoceria inhibit expression of genes associated with inflammation and angiogenesis in the retina of Vldlr null mice. Exp. Eye Res. 116, 63–74 (2013).
  Medline CASGoogle Scholar
• 15. Goushbolagh NA , Farhood B , Astani A , Nikfarjam A , Kalantari M , Zare MH . Quantitative cytotoxicity, cellular uptake and radioprotection effect of cerium oxide nanoparticles in MRC-5 normal cells and MCF-7 cancerous cells. BioNanoScience 8(3), 769–777 (2018).
  Google Scholar
• 16. Kumari P , Saifi MA , Khurana A , Godugu C . Cardioprotective effects of nanoceria in a murine model of cardiac remodeling. J. Trace Elem. Med. Biol. 50, 198–208 (2018).
  Medline CASGoogle Scholar
• 17. Eriksson P , Tal AA , Skallberg A et al. Cerium oxide nanoparticles with antioxidant capabilities and gadolinium integration for MRI contrast enhancement. Sci. Rep. 8(1), 6999 (2018).
  MedlineGoogle Scholar
• 18. Celardo I , Traversa E , Ghibelli L . Cerium oxide nanoparticles: a promise for applications in therapy. J. Exp. Ther. Oncol. 9(1), 47–51 (2011).
  Medline CASGoogle Scholar
• 19. Celardo I , Pedersen JZ , Traversa E , Ghibelli L . Pharmacological potential of cerium oxide nanoparticles. Nanoscale 3(4), 1411–1420 (2011).
  Medline CASGoogle Scholar
• 20. Mason J , Mason A , Cork M . Topical preparations for the treatment of psoriasis: a systematic review. Br. J. Dermatol. 142(3), 351–364 (2000).
  Google Scholar
• 21. Schäfer-Korting M , Mehnert W , Korting H-C . Lipid nanoparticles for improved topical application of drugs for skin diseases. Adv. Drug Deliv. Rev. 59(6), 427–443 (2007).
  MedlineGoogle Scholar
• 22. Zhang Z , Tsai PC , Ramezanli T , Michniak‐Kohn BB . Polymeric nanoparticles‐based topical delivery systems for the treatment of dermatological diseases. Wiley Interdisciplinary Rev. 5(3), 205–218 (2013).
  CASGoogle Scholar
• 23. Di Cesare A , Di Meglio P , Nestle FO . The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J. Investig. Dermatol. 129(6), 1339–1350 (2009).
  MedlineGoogle Scholar
• 24. Kryczek I , Bruce AT , Gudjonsson JE et al. Induction of IL-17+ T cell trafficking and development by IFN-γ: mechanism and pathological relevance in psoriasis. J. Immunol. 181(7), 4733–4741 (2008).
  Medline CASGoogle Scholar
• 25. Ha H , Wang H , Siebenlist U . IL-17 is crucial for psoriatic inflammation, but also initiates an anti-inflammatory feedback loop via signaling into keratinocytes. J. Investig. Dermatol. (2018).
  Google Scholar
• 26. Sangomla S , Saifi MA , Khurana A , Godugu C . Nanoceria ameliorates doxorubicin induced cardiotoxicity: possible mitigation via reduction of oxidative stress and inflammation. J. Trace Elem. Med. Biol. 47, 53–62 (2018).
  Medline CASGoogle Scholar
• 27. Saifi MA , Sangomla S , Khurana A , Godugu C . Protective effect of nanoceria on cisplatin-induced nephrotoxicity by amelioration of oxidative stress and pro-inflammatory mechanisms. Biol. Trace Elem. Res. 189(1), 145–156 (2018).
  MedlineGoogle Scholar
• 28. Karkale S , Khurana A , Saifi MA , Godugu C , Talla V . Oropharyngeal administration of silica in Swiss mice: a robust and reproducible model of occupational pulmonary fibrosis. Pulmon. Pharmacol. Ther. 51, 32–40 (2018).
  Medline CASGoogle Scholar
• 29. Karkale S , Khurana A , Saifi MA , Godugu C , Talla V . Andrographolide ameliorates silica induced pulmonary fibrosis. Int. Immunopharmacol. 62, 191–202 (2018).
  Medline CASGoogle Scholar
• 30. Kumar GS , Kulkarni A , Khurana A , Kaur J , Tikoo K . Selenium nanoparticles involve HSP-70 and SIRT1 in preventing the progression of type 1 diabetic nephropathy. Chemico-Biolog. Interact. 223, 125–133 (2014).
  Medline CASGoogle Scholar
• 31. Khurana A , Tekula S , Godugu C . Nanoceria suppresses multiple low doses of streptozotocin-induced type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis. Nanomedicine 13(15), 1905–1922 (2018).
  CASGoogle Scholar
• 32. Bale S , Venkatesh P , Sunkoju M , Godugu C . An adaptogen: Withaferin A ameliorates in vitro and in vivo pulmonary fibrosis by modulating the interplay of fibrotic, matricelluar proteins, and cytokines. Front. Pharmacol. 9, 248 (2018).
  MedlineGoogle Scholar
• 33. Tiruveedi VL , Bale S , Khurana A , Godugu C . Withaferin A, a novel compound of Indian ginseng (Withania somnifera), ameliorates C erulein‐induced acute pancreatitis: possible role of oxidative stress and inflammation. Phytother. Res. 32(12), 2586–2596 (2018).
  Medline CASGoogle Scholar
• 34. Nerurkar L , McColl A , Graham G , Cavanagh J . The systemic response to topical Aldara treatment is mediated through direct TLR7 stimulation as Imiquimod enters the circulation. Sci. Rep. 7(1), 16570 (2017).
  MedlineGoogle Scholar
• 35. Bhalerao J , Bowcock AM . The genetics of psoriasis: a complex disorder of the skin and immune system. Hum. Mol. Genet. 7(10), 1537–1545 (1998).
  Medline CASGoogle Scholar
• 36. Mantovani L , Medaglia M , Piacentini P et al. Burden of moderate-to-severe plaque psoriasis and new therapeutic approaches (secukinumab): an Italian perspective. Dermatol. Ther. 6(2), 151–167 (2016).
  Google Scholar
• 37. Stawczyk-Macieja M , Rębała K , Szczerkowska-Dobosz A et al. Evaluation of psoriasis genetic risk based on five susceptibility markers in a population from northern Poland. PloS ONE 11(9), e0163185 (2016).
  MedlineGoogle Scholar
• 38. Fortune DG , Richards HL , Griffiths CE , Main CJ . Psychological stress, distress and disability in patients with psoriasis: consensus and variation in the contribution of illness perceptions, coping and alexithymia. Br. J. Clin. Psychol. 41(2), 157–174 (2002).
  MedlineGoogle Scholar
• 39. de Korte J , Mombers FM , Bos JD , Sprangers MA . Quality of life in patients with psoriasis: a systematic literature review. J. Investig. Dermatol. Symp. Proc. 32(12), 2586–2596 (2004).
  Google Scholar
• 40. Lowes MA , Russell CB , Martin DA , Towne JE , Krueger JG . The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses. Trends Immunol. 34(4), 174–181 (2013).
  Medline CASGoogle Scholar
• 41. Pulido-Reyes G , Rodea-Palomares I , Das S et al. Untangling the biological effects of cerium oxide nanoparticles: the role of surface valence states. Sci. Rep. 5, 15613 (2015).
  Medline CASGoogle Scholar
• 42. Hirst SM , Karakoti AS , Tyler RD , Sriranganathan N , Seal S , Reilly CM . Anti‐inflammatory properties of cerium oxide nanoparticles. Small 5(24), 2848–2856 (2009).
  Medline CASGoogle Scholar
• 43. Malyukin Y , Maksimchuk P , Seminko V , Okrushko E , Spivak N . Limitations of self-regenerative antioxidant ability of nanoceria imposed by oxygen diffusion. J. Phys. Chem. C 122(28), 16406–16411 (2018).
  CASGoogle Scholar
• 44. Newkirk GM , Wu H , Santana I , Giraldo JP . Catalytic scavenging of plant reactive oxygen species in vivo by anionic cerium oxide nanoparticles. J. Visual. Exp. (138), e58373–e58373 (2018).
  Google Scholar
• 45. Baldim V , Bedioui F , Mignet N , Margaill I , Berret J-F . The enzyme-like catalytic activity of cerium oxide nanoparticles and its dependency on Ce³⁺ surface area concentration. Nanoscale 10(15), 6971–6980 (2018).
  Medline CASGoogle Scholar
• 46. Sirsjö A , Karlsson M , Gidöf A , Rollman O , Törmä H . Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine‐stimulated cultured keratinocytes. Br. J. Dermatol. 134(4), 643–648 (1996).
  Medline CASGoogle Scholar
• 47. McKay IA , Leigh IM . Altered keratinocyte growth and differentiation in psoriasis. Clin. Dermatol. 13(2), 105–114 (1995).
  Medline CASGoogle Scholar
• 48. Cox CA , Shi G , Yin H et al. Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J. Immunol. 180(11), 7414–7422 (2008).
  Medline CASGoogle Scholar
• 49. Asha K , Singal A , Sharma SB , Arora VK , Aggarwal A . Dyslipidaemia & oxidative stress in patients of psoriasis: emerging cardiovascular risk factors. Ind. J. Med. Res. 146(6), 708 (2017).
  Medline CASGoogle Scholar
• 50. Shi Z-R , Tan G-Z , Cao C-X et al. Decrease of galectin-3 in keratinocytes: a potential diagnostic marker and a critical contributor to the pathogenesis of psoriasis. J. Autoimmunity 89, 30–40 (2018).
  Medline CASGoogle Scholar
• 51. Jiang M , Sun Z , Dang E et al. TGFβ/SMAD/microRNA-486-3p signaling axis mediates keratin 17 expression and keratinocyte hyperproliferation in psoriasis. J. Investig. Dermatol. 137(10), 2177–2186 (2017).
  Medline CASGoogle Scholar
• 52. Mohammed J , Gunderson AJ , Khong H-H , Koubek RD , Udey MC , Glick AB . TGFβ1 overexpression by keratinocytes alters skin dendritic cell homeostasis and enhances contact hypersensitivity. J. Investig. Dermatol. 133(1), 135–143 (2013).
  Medline CASGoogle Scholar
• 53. Blauvelt A . Dual inhibition of IL-12/IL-23 and selective inhibition of IL-23 in psoriasis. In: Biologic and Systemic Agents in Dermatology. Yamauchi PS (Ed.). Springer, Cham, Switzerland, 123–131 (2018).
  Google Scholar
• 54. Lin Z-M , Ma M , Li H et al. Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17. Pharmacol. Res. 129, 443–452 (2018).
  Medline CASGoogle Scholar
• 55. Nguyen LTH , Ahn S-H , Nguyen UT , Yang I-J . Dang-Gui-Liu-Huang Tang a traditional herbal formula, ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting IL-22 production. Phytomedicine 47, 48–57 (2018).
  MedlineGoogle Scholar
• 56. Al-Shobaili HA , Farhan J , Zafar U , Rasheed Z . Functional role of human interleukin-32 and nuclear transcription factor-kB in patients with psoriasis and psoriatic arthritis. Int. J. Health Sci. 12(3), 29 (2018).
  Google Scholar
• 57. Hampton PJ , Jans R , Flockhart RJ , Parker G , Reynolds NJ . Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2). J. Cell. Physiol. 227(4), 1529–1537 (2012).
  Medline CASGoogle Scholar