Review

Nanoscaffolds in promoting regeneration of the peripheral nervous system

Chen Aijie

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

Guangdong Provincial Key Laboratory of Construction & Detection in Tissue Engineering, Guangzhou 510515, China

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Lai Xuan

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

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Liang Huimin

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

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Zhang Yanli

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

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Kang Yiyuan

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

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Lin Yuqing

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

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Shao Longquan

*Author for correspondence:

E-mail Address: shaolongquan@smu.edu.cn

Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, Guangdong 510515, China

Guangdong Provincial Key Laboratory of Construction & Detection in Tissue Engineering, Guangzhou 510515, China

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Published Online:23 May 2018https://doi.org/10.2217/nnm-2017-0389

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Abstract

The ability to surgically repair peripheral nerve injuries is urgently needed. However, traditional tissue engineering techniques, such as autologous nerve transplantation, have some limitations. Therefore, tissue engineered autologous nerve grafts have become a suitable choice for nerve repair. Novel tissue engineering techniques derived from nanostructured conduits have been shown to be superior to other successful functional neurological structures with different scaffolds in terms of providing the required structures and properties. Additionally, different biomaterials and growth factors have been added to nerve scaffolds to produce unique biological effects that promote nerve regeneration and functional recovery. This review summarizes the application of different nanoscaffolds in peripheral nerve repair and further analyzes how the nanoscaffolds promote peripheral nerve regeneration.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 13, No. 9

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Received 21 December 2017

Accepted 1 March 2018

Published online 23 May 2018

Published in print May 2018

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Financial & competing interests disclosure

This work was supported by the National Key Research and Development Program of China (2016YFC1102605, 2016YFC1102603), the National Natural Science Foundation of China (51672122) and the Natural Science Foundation of Guang-dong Province of China (2016A030313673 and 2015A030313299). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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