Synthesis of theranostic epithelial cell adhesion molecule targeted mesoporous silica nanoparticle with gold gatekeeper for hepatocellular carcinoma

Papers of special note have been highlighted as: • of interest; •• of considerable interest

References

• 1 Li Y, Farmer RW, Yang Y, Martin RCG. Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence. BMC Cancer 16, 228–237 (2016). • Evaluates epithelial cell adhesion molecule expression in hepatocellular carcinoma and the effects of epithelial cell adhesion molecule to established chemotherapy.
  Medline CASGoogle Scholar
• 2 Lin S, Hoffmann K, Schemmer P. Treatment of hepatocellular carcinoma: a systematic review. Liver Cancer 1(3–4), 144–158 (2012).
  Medline CASGoogle Scholar
• 3 Greco F, Vicent MJ. Combination therapy: opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines. Adv. Drug Deliv. Rev. 61(13), 1203–1213 (2009).
  Medline CASGoogle Scholar
• 4 Alibolandi M, Ramezani M, Abnous K, Sadeghi F, Hadizadeh F. Comparative evaluation of polymersome versus micelle structures as vehicles for the controlled release of drugs. J. Nanopart. Res. 17, 76 (2015).
  Google Scholar
• 5 Alibolandi M, Abnous K, Hadizadeh F et al. Dextran-poly lactide-co-glycolide polymersomes decorated with folate-antennae for targeted delivery of docetaxel to breast adenocarcinima in vitro and in vivo. J. Control. Release 241, 45–56 (2016).
  Medline CASGoogle Scholar
• 6 Alibolandi M, Abnous K, Sadeghi F, Hosseinkhani H, Ramezani M, Hadizadeh F. Folate receptor-targeted multimodal polymersomes for delivery of quantum dots and doxorubicin to breast adenocarcinoma: in vitro and in vivo evaluation. Int. J. Pharm. 500(1–2), 162–178 (2016). • Reports the design and application of tumor-targeted quantum dot-based theranostic polymersome for the imaging and chemotherapy of breast cancer.
  Medline CASGoogle Scholar
• 7 Sameti M, Bohr G, Ravi Kumar MN et al. Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery. Int. J. Pharm. 266(1–2), 51–60 (2003).
  Medline CASGoogle Scholar
• 8 Ambrogio MW, Thomas CR, Zhao YL, Zink JI, Stoddart JF. Mechanized silica nanoparticles: a new frontier in theranostic nanomedicine. Acc. Chem. Res. 44(10), 903–913 (2011).
  Medline CASGoogle Scholar
• 9 Palanikumar L, Choi ES, Cheon JY, Joo SH, Ryu J-H. Noncovalent polymer- gatekeeper in mesoporous silica nanoparticles as a targeted drug delivery platform. Adv. Funct. Mater. 25, 957–965 (2015). •• Reports the design of a novel type of stimulus-responsive polymer gatekeeper dual drug delivery system for tumor targeting.
  CASGoogle Scholar
• 10 Hu C, Yu L, Zheng Z et al. Tannin as a gatekeeper of pH-responsive mesoporous silica nanoparticles for drug delivery. RSC Adv. 5, 85436–85441 (2015).
  CASGoogle Scholar
• 11 Lai C-Y, Trewyn BG, Jeftinija DM et al. A mesoporous silica nanosphere-based carrier system with chemically removable cds nanoparticle caps for stimuli- responsive controlled release of neurotransmitters and drug molecules. J. Am. Chem. Soc. 125(15), 4451–4459 (2003).
  Medline CASGoogle Scholar
• 12 Giri S, Trewyn BG, Stellmaker MP, Lin VS-Y. Stimuli-responsive controlled- release delivery system based on mesoporous silica nanorods capped with magnetic nanoparticles. Angew. Chem. Int. Ed. Engl. 44(32), 5038–5044 (2005).
  Medline CASGoogle Scholar
• 13 Radu DR, Lai C-Y, Jeftinija K, Rowe EW, Jeftinija S, Lin VS-Y. A polyamidoamine dendrimer-capped mesoporous silica nanosphere-based gene transfection reagent. J. Am. Chem. Soc. 126(41), 13216–13217 (2004).
  Medline CASGoogle Scholar
• 14 Thomas CR, Ferris DP, Lee JH et al. Noninvasive remote-controlled release of drug molecules in vitro using magnetic actuation of mechanized nanoparticles. J. Am. Chem. Soc. 132(31), 10623–10625 (2010).
  Medline CASGoogle Scholar
• 15 Amin M, Badiee A, Jaafari MR. Improvement of pharmacokinetic and antitumor activity of pegylated liposomal doxorubicin by targeting with N-methylated cyclic RGD peptide in mice bearing C-26 colon carcinomas. Int. J. Pharm. 458(2), 324–333 (2013).
  Medline CASGoogle Scholar
• 16 Oh SS, Lee BF, Leibfarth FA et al. Synthetic aptamer-polymer hybrid constructs for programmed drug delivery into specific target cells. J. Am. Chem. Soc. 136(42), 15010–15015 (2014). • This article is of interest because of novelty in design and synthesis of multifunctional systems that combine the advantages of aptamers and polymers for programmed drug delivery applications.
  Medline CASGoogle Scholar
• 17 Lu J, Zhao W, Huang Y et al. Targeted delivery of doxorubicin by folic acid-decorated dual functional nanocarrier. Mol. Pharm. 11(11), 4164–4178 (2014).
  Medline CASGoogle Scholar
• 18 Cho B. RNA-RNA SELEX. Methods Mol. Biol. 1240, 39–47 (2015).
  Medline CASGoogle Scholar
• 19 Wu X, Ding B, Gao J et al. Second-generation aptamer-conjugated PSMA- targeted delivery system for prostate cancer therapy. Int. J. Nanomedicine 6, 1747–1756 (2011).
  Medline CASGoogle Scholar
• 20 Mu Q, Kievit FM, Kant RJ, Lin G, Jeon M, Zhang M. Anti-HER2/neu peptide- conjugated iron oxide nanoparticles for targeted delivery of paclitaxel to breast cancer cells. Nanoscale 7(43), 18010–18014 (2015).
  Medline CASGoogle Scholar
• 21 Wu G, Barth RF, Yang W, Kawabata S, Zhang L, Green-Church K. Targeted delivery of methotrexate to epidermal growth factor receptor-positive brain tumors by means of aetuximab (IMC-C225) dendrimer bioconjugates. Mol. Cancer Ther. 5(1), 52–59 (2006).
  Medline CASGoogle Scholar
• 22 Li L, Hou J, Liu X et al. Nucleolin-targeting liposomes guided by aptamer AS1411for the delivery of siRNA for the treatment of malignant melanomas. Biomaterials 35(12), 3840–3850 (2014).
  Medline CASGoogle Scholar
• 23 Hayward SL, Wilson CL, Kidambi S. Hyaluronic acid-conjugated liposome nanoparticles for targeted delivery to CD44 overexpressing glioblastoma cells. Oncotarget 7(23), 34158–34171 (2016).
  MedlineGoogle Scholar
• 24 Alibolandi M, Ramezani M, Sadeghi F, Abnous K, Hadizadeh F. Epithelial cell adhesion molecule aptamer conjugated PEG-PLGA nanopolymersomes for targeted delivery of doxorubicin to human breast adenocarcinoma cell line in vitro. Int. J. Pharm. 479(1), 241–251 (2015).
  Medline CASGoogle Scholar
• 25 Tivnan A, Orr WS, Gubala V et al. Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles. PLoS ONE 7(5), e38129 (2012).
  Medline CASGoogle Scholar
• 26 Yamashita T, Honda M, Nakamoto Y et al. Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma. Hepatology 57(4), 1484–1497 (2013).
  Medline CASGoogle Scholar
• 27 Terris B, Cavard C, Perret C. EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma. J. Hepatol. 52(2), 280–281 (2010).
  Medline CASGoogle Scholar
• 28 He X, Zhao Y, He D, Wang K, Xu F, Tang J. ATP-responsive controlled release system using aptamer- functionalized mesoporous silica nanoparticles. Langmuir 28(35), 12909–12915 (2012). • Describes the synthesis and characterization of mesoporous silica nanoparticles.
  Medline CASGoogle Scholar
• 29 Jana NR, Gearheart L, Murphy CJ. Seeding growth for size control of 5–40 nm diameter gold nanoparticles. Langmuir 17(22), 6782–6786 (2001).
  CASGoogle Scholar
• 30 Alibolandi M, Ramezani M, Abnous K et al. In vitro and in vivo evaluation of therapy targeting epithelial-cell adhesion-molecule aptamers for non-small cell lung cancer. J. Controlled Release. 209, 88–100 (2015).
  Medline CASGoogle Scholar
• 31 Kumar B, Kulanthaivel S, Mondal A et al. Mesoporous silica nanoparticle based enzyme responsive system for colon specific drug delivery through guar gum capping. Colloid Surf. B 150, 352–361 (2016).
  MedlineGoogle Scholar
• 32 Shigdar S, Lin J, Yu Y, Pastuovic M, Wei M, Duan W. RNA aptamer against a cancer stem cell marker epithelial cell adhesion molecule. Cancer Sci. 102(5), 991–998 (2011).
  Medline CASGoogle Scholar
• 33 Mojardín L, Botet J, Quintales L, Moreno S, Salas M. New insights into the RNA based mechanism of action of the anticancer drug 5′-fluorouracil in eukaryotic cells. PLoS ONE 8(11), e78172–e78182 (2013).
  Medline CASGoogle Scholar
• 34 Alibolandi M, Ramezani M, Abnous K, Hadizadeh F. AS1411 aptamer-decorated biodegradable polyethylene glycol-poly(lactic-co-glycolic acid) nanopolymersomes for the targeted delivery of gemcitabine to non-small cell lung cancer In vitro. J. Pharm. Sci. 105(5), 1741–1750 (2016).
  Medline CASGoogle Scholar
• 35 Taghdisi SM, Danesh NM, Sarreshtehdar Emrani A et al. Targeted delivery of epirubicin to cancer cells by PEGylated A10 aptamer. J. Drug Target. 21(8), 739–744 (2013).
  Medline CASGoogle Scholar
• 36 Alshaer W, Hillaireau H, Vergnaud J, Ismail S, Fattal E. Functionalizing liposomes with anti-CD44 aptamer for selective targeting of cancer cells. Bioconjug. Chem 26(7), 1307–1313 (2015).
  Medline CASGoogle Scholar
• 37 Suresh D, Zambre A, Chanda N et al. Bombesin peptide conjugated gold nanocages internalize via clathrin mediated endocytosis. Bioconjug. Chem. 25(8), 1565–1579 (2014).
  Medline CASGoogle Scholar
• 38 Li Y, Farmer RW, Yang Y, Martin RC. Epithelial cell adhesion molecule in human hepatocellular carcinoma cell lines: a target of chemoresistence. BMC Cancer 16, 228–237 (2016).
  Medline CASGoogle Scholar
• 39 Chen Z, Lian F, Wang X, Chen Y, Tang N. Arginine-glycine-aspartic acid- polyethylene glycol-polyamidoamine dendrimer conjugate improves liver-cell aggregation and function in 3-D spheroid culture. Int. J. Nanomedicine 11, 4247–4259 (2016).
  Medline CASGoogle Scholar
• 40 Peng C, Zheng L, Chen Q et al. PEGylated dendrimer-entrapped gold nanoparticles for in vivo blood pool and tumor imaging by computed tomography. Biomaterials 33(4), 1107–1119 (2012). • Reports the synthesis of dendrimer-entrapped gold nanoparticles and it tackles computed tomography imaging applications.
  Medline CASGoogle Scholar
• 41 Maeda H, Wu J, Sawa T, Matsumura Y, Hori K. Tumor vascular permeability and the epr effect in macromolecular therapeutics: a review. J. Control. Release 65(1–2), 271–284 (2000).
  Medline CASGoogle Scholar
• 42 Maeda H. The enhanced permeability and retention (EPR) effect in tumor vasculature: the key role of tumor-selective macromolecular drug targeting. Adv. Enzyme Regul. 41, 189–207 (2001).
  Medline CASGoogle Scholar