We use cookies to improve your experience. By continuing to browse this site, you accept our cookie policy.×
Skip main navigation
Aging Health
Bioelectronics in Medicine
Biomarkers in Medicine
Breast Cancer Management
CNS Oncology
Colorectal Cancer
Concussion
Epigenomics
Future Cardiology
Future Medicine AI
Future Microbiology
Future Neurology
Future Oncology
Future Rare Diseases
Future Virology
Hepatic Oncology
HIV Therapy
Immunotherapy
International Journal of Endocrine Oncology
International Journal of Hematologic Oncology
Journal of 3D Printing in Medicine
Lung Cancer Management
Melanoma Management
Nanomedicine
Neurodegenerative Disease Management
Pain Management
Pediatric Health
Personalized Medicine
Pharmacogenomics
Regenerative Medicine
Published Online:https://doi.org/10.2217/nmt-2023-0026
Free first page

References

  • 1. Tiwari S, Atluri V, Kaushik A, Yndart A, Nair M. Alzheimer's disease: pathogenesis, diagnostics, and therapeutics. Int. J. Nanomed. 14, 5541–5554 (2019).
  • 2. Association AS. 2018 Alzheimer's disease facts and figures. Alzheimer's Dement. 14(3), 367–429 (2018).
  • 3. Tanzi RE. The genetics of Alzheimer disease. Cold Spring Harbor Perspect. Med. 2(10), 1–2 (2012).
  • 4. Lambert J-C, Amouyel P. Genetics of Alzheimer's disease: new evidences for an old hypothesis? Curr. Opin. Gene. Develop. 21(3), 295–301 (2011).
  • 5. Giri M ZM, Lü Y. Genes associated with Alzheimer's disease: an overview and current status. Dovepress doi: https://doi.org/10.2147/CIA.S105769 (2016).
  • 6. Mahley RW. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology. Science 240(4852), 622–630 (1988).
  • 7. Chen JX, Yan SS. Role of mitochondrial amyloid-beta in Alzheimer's disease. J. Alzheimer's Dis.: JAD 20(Suppl. 2), S569–S578 (2010).
  • 8. Crews L, Masliah E. Molecular mechanisms of neurodegeneration in Alzheimer's disease. Hum. Mol. Genet. 19(R1), R12–20 (2010).
  • 9. Walsh S, Merrick R, Richard E, Nurock S, Brayne C. Lecanemab for Alzheimer's disease. BMJ 379, 3010 (2022).
  • 10. Couzin-Frankel J, Piller C. Alzheimer's drug stirs excitement-and concerns. Science 378(6624), 1030–1031 (2022).
  • 11. Van Dyck CH, Swanson CJ, Aisen P et al. Lecanemab in early Alzheimer's disease. N. Engl. J. Med. 388(1), 9–21 (2023).
  • 12. Legleiter J, Czilli DL, Gitter B, Demattos RB, Holtzman DM, Kowalewski T. Effect of different anti-A–beta antibodies on A–beta fibrillogenesis as assessed by atomic force microscopy. J. Mol. Biol. 335(4), 997–1006 (2004).
  • 13. Solomon B, Koppel R, Hanan E, Katzav T. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl Acad. Sci. USA 93(1), 452–455 (1996).
  • 14. Lord A, Gumucio A, Englund H et al. An amyloid-beta protofibril-selective antibody prevents amyloid formation in a mouse model of Alzheimer's disease. Neurobiol. Dis. 36(3), 425–434 (2009).
  • 15. Swanson CJ, Zhang Y, Dhadda S et al. A randomized, double-blind, phase 2b proof-of-concept clinical trial in early Alzheimer's disease with lecanemab, an anti-Aβ protofibril antibody. Alzheimer's Res. Ther. 13(1), 80 (2021).
  • 16. Söllvander S, Ekholm-Pettersson F, Brundin RM et al. Increased number of plasma B cells producing autoantibodies against Aβ42 protofibrils in Alzheimer's disease. J. Alzheimer's Dis.: JAD 48(1), 63–72 (2015).
  • 17. Tucker S, Möller C, Tegerstedt K et al. The murine version of BAN2401 (mAb158) selectively reduces amyloid-β protofibrils in brain and cerebrospinal fluid of tg-ArcSwe mice. J. Alzheimer's Dis.: JAD 43(2), 575–588 (2015).
  • 18. Magnusson K, Sehlin D, Syvänen S et al. Specific uptake of an amyloid-β protofibril-binding antibody-tracer in AβPP transgenic mouse brain. J. Alzheimer's Dis.: JAD 37(1), 29–40 (2013).
  • 19. Söderberg L, Johannesson M, Nygren P et al. Lecanemab, Aducanumab, and Gantenerumab - binding profiles to different forms of amyloid-beta might explain efficacy and side effects in clinical trials for Alzheimer's disease. Neurotherapeutics 20(1), 195–206 (2023).
  • 20. Rentería ME, Mitchell BL, De Lara AM. Genetic testing for Alzheimer's disease: trends, challenges and ethical considerations. Curr. Opin. Psychiatry 33(2), 136–140 (2020).