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COL10A1 is a potential immunotherapy biomarker associated with immune infiltration and deficient mismatch repair in colon cancer

    Shuo Cai‡

    *Author for correspondence:

    E-mail Address: shuocai4406@163.com

    Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    ‡Authors contributed equally

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    ,
    Zhiwei Sun‡

    VIP-II Division of Medical Department, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    ‡Authors contributed equally

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    ,
    Yan Yan

    Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    ,
    Weifeng Li

    Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    &
    Qi Wu

    **Author for correspondence:

    E-mail Address: wuqi1973@bjmu.edu.cn

    Department of Endoscopy Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing, 100142, China

    Published Online:https://doi.org/10.2217/imt-2023-0096

    Aim: Our study aimed to identify the role of COL10A1 in colon cancer, including interaction with immune infiltrates and somatic mutations. Methods: COL10A1 expression and prognostic value were assessed. Correlations between COL10A1 and various immune parameters were conducted by bioinformatic analysis. Results: Our study demonstrated that COL10A1 is overexpressed in colon cancer and correlates with poor patient survival. The expression level of COL10A1 is significantly associated with mismatch repair deficiency and immune infiltration. High expression of COL10A1 may confer greater sensitivity to anti-PD-1 treatment in colon cancer patients. Conclusion: COL10A1 is a potential diagnostic biomarker associated with deficient mismatch repair and immune infiltration in colon cancer.

    Plain language summary

    Colorectal cancer (CRC) is a deadly disease and we do not have a cure. Immunotherapy is a new method that can help CRC patients to live longer, but it only works for some people. To find out who will get good results with immunotherapy, we looked at a protein named COL10A1. We found more COL10A1 in colon cancer tissues than in healthy tissues. CRC patients with a lot of COL10A1 are more likely to die than those patients with low levels of this protein. COL10A1 can interact with some immune cells and by looking at how much COL10A1 is in different CRC patients, we may be able to choose the right patients to treat with immunotherapy.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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