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Short Communication

Association between serum aminotransferase enzymes–lipid profile ratio and spontaneous HCV clearance in blood donors

    Ashraf A Tabll

    *Author for correspondence:

    E-mail Address: ashraftabll@yahoo.com

    Microbial Biotechnology Department, National Research Centre, Giza, Egypt

    ,
    Marwa A Kodous

    Chemistry Department, Faculty of Science, Port-Said University, Port-Said, Egypt

    ,
    Ayman T Abbas

    Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdul-Aziz University, Jeddah, Saudi Arabia

    Biotechnology Research Laboratories, Gastroenterology Surgery Center, Mansoura University, Mansoura, Egypt

    ,
    Mohamed M Omran

    Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt

    &
    Elsherbeny H Elsayed

    Chemistry Department, Faculty of Science, Port-Said University, Port-Said, Egypt

    Published Online:https://doi.org/10.2217/fvl.15.103

    Aim: Study the role of the aminotransferase lipid profile ratio in the spontaneous clearance of HCV. Materials & methods: Blood samples from 68 blood donors were classified into three groups: negative for HCV antibodies (control group I), positive anti-HCV with negative HCV-RNA, (group II) and positive anti-HCV with positive HCV-RNA (group III). Results: A significant linear correlation was observed between the HCV-RNA levels and aminotransferase enzymes–lipid profile ratio as indicated by the values of (AST)/triglycerides (r = 0.577; p = 0.003) and ALT/triglycerides (r = 0.508; p < 0.009). AST/high-density lipoprotein had an area under the receiver operating characteristic curve of 0.72 for discriminating between nonspontaneous HCV-clearance from spontaneous HCV-clearance patients. Conclusion: AST/high-density lipoprotein can be used for the prediction of HCV clearance without treatment.

    Papers of special note have been highlighted as: • of interest

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