Correlation analysis of HHV-6A viral load and anti-TPO antibody levels in patients with Hashimoto's thyroiditis
Abstract
Aim: This study investigated the correlation between anti-thyroid peroxidase (anti-TPO) antibody levels and human herpesvirus 6 (HHV-6) viral load as triggers for Hashimoto's thyroiditis (HT). Materials & methods: The study included 60 HT patients, 60 patients with non-autoimmune thyroid disease, and 60 subjects with normal thyroid function. HHV-6 viral loads in serum samples were detected using real-time PCR. Results: A significant correlation was found between the increase in viral load and increased levels of anti-TPO antibodies in serum samples from HT patients (p = 0.001). Conclusion: The aim of this study was to explore the potential involvement of HHV-6A in the onset of HT, with the goal of identifying improved treatment options for affected individuals.
Plain language summary
Hashimoto's thyroiditis (HT) is an autoimmune disease. This means that the immune system mistakenly attacks healthy cells and tissues. HT mainly affects the thyroid gland. This study aimed to find out if there is a relationship between a type of herpesvirus, human herpesvirus 6 (HHV-6), and the number of immune cells against a protein in the thyroid gland, thyroid peroxidase (anti-TPO), with the development of HT. The study included 60 patients with HT, 60 patients with non-autoimmune thyroid disease and 60 subjects with normal thyroid function. The results showed that there was a relationship between the presence of HHV-6 and anti-TPO in HT patients. This suggests that HHV-6 plays a role in the development of HT.
Papers of special note have been highlighted as: • of interest; •• of considerable interest
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