Review

An update on miRNAs as biological and clinical determinants in colorectal cancer: a bench-to-bedside approach

Department of Clinical Laboratory, Shanghai Tenth People's Hospital Affiliated with Tongji University, Shanghai 200072, China

^‡Authors contributed equally

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Junlan Feng^‡

Department of Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China

^‡Authors contributed equally

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Huanlong Qin

Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, 301 Yanchang Road, Shanghai 200072, China

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Yanlei Ma

Department of GI Surgery, Shanghai Tenth People's Hospital Affiliated with Tongji University, 301 Yanchang Road, Shanghai 200072, China

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Ajay Goel

*Author for correspondence:

E-mail Address: ajay.goel@baylorhealth.edu

Center for Gastrointestinal Research & Center for Epigenetics, Cancer Prevention & Cancer Genomics, Baylor Research Institute & Charles A Sammons Cancer Center, Baylor University Medical Center, Dallas, TX, USA

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Published Online:15 Jun 2015https://doi.org/10.2217/fon.15.83

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Abstract

ABSTRACT

Colorectal carcinogenesis represents a sequential progression of normal colonic mucosa from adenoma to carcinoma. It has become apparent that miRNA deregulation contributes to the initiation and progression of colorectal cancer (CRC). These oncogenic or tumor-suppressive miRNAs interact with intracellular signaling networks and lead to alteration of cell proliferation, apoptosis, metastasis and even response to chemotherapeutic treatments. This article aims to review the cutting edge progress in the discovery of the role of novel mechanisms for miRNAs in the development of CRC. We will also discuss the potential use of miRNAs as biomarkers for early diagnosis and prognosis of CRC. Furthermore, with advancements in RNA delivery technology, it is anticipated that manipulation of miRNAs may offer an alternative therapy for CRC treatment.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Published online 15 June 2015

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Financial & competing interests disclosure

This work was supported by grants R01 CA72851, CA181572, CA184792 and U01 CA187956 from the National Cancer Institute, NIH, a pilot grant from Charles A Sammons Cancer Center, and funds from the Baylor Research Institute to A Goel. This work was also supported by grants from the National Natural Science Foundation of China (no. 81372615 and no. 81201884), Shanghai Science and Technology Development Fund (no. 12140902300 and no. 12410707400), Shanghai Health System Outstanding Young Talent Training Plan (no. XYQ2013118) and Shanghai Tenth people's Hospital CLIMB project for outstanding Young Clinical Investigators (W Weng). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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