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The causality between Type 2 diabetes and breast cancer: a bidirectional two-sample Mendelian randomization study

    Lihan Zhang‡

    The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Shuochuan Liu‡

    The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Guangxing Yue

    The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China

    ,
    Hong Niu

    The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China

    ,
    Mengjin Hu

    Xuanwu Hospital, Capital Medical University, Beijing, 100053, China

    ,
    Yuling Zheng

    **Author for correspondence:

    E-mail Address: zhengyl@hactcm.edu.cn

    The First Affiliated Hospital of Henan University of CM, Zhengzhou, 450008, China

    &
    Jingwen Tang

    *Author for correspondence:

    E-mail Address: tjw0371@163.com

    The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, 450008, China

    Published Online:https://doi.org/10.2217/fon-2023-0708

    Objective: Observational studies showed that Type 2 diabetes increased the risk of breast cancer, and vice versa. However, it is uncertain whether the link is causal or just due to confounding factors. Using bidirectional Mendelian randomization analysis, we assessed the bidirectional causal relationship from a genetic level. Methods: Large genome-wide association studies yielded summary-level data for Type 2 diabetes and breast cancer. Results: Genetically predicted Type 2 diabetes presented no statistically significant association with overall breast cancer or its subtypes. Similarly, genetically predicted overall breast cancer or its subtypes had no causal effect on Type 2 diabetes. Sensitivity analyses yielded similar results. Conclusion: Our bidirectional Mendelian randomization studies revealed no causal links between Type 2 diabetes and breast cancer.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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