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Immune-related genes LAMA2 and IL1R1 correlate with tumor sites and predict poor survival in pancreatic adenocarcinoma

    Mengna Zhang‡

    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, 430071, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Lirong Zeng‡

    Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Yanan Peng

    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, 430071, China

    ,
    Bin Fan

    *Author for correspondence:

    E-mail Address: fb824@126.com

    Hepatobiliary Surgery, The Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000, China

    ,
    PengFei Chen

    **Author for correspondence:

    E-mail Address: escpff@163.com

    Department of Gastroenterology, The Central Hospital of Enshi Autonomous Prefecture, Enshi, 445000, China

    &
    Jing Liu

    ***Author for correspondence:

    E-mail Address: liujing_gi@126.com

    Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China

    Hubei Clinical Center & Key Lab of Intestinal & Colorectal Diseases, Wuhan, 430071, China

    Published Online:https://doi.org/10.2217/fon-2020-1012

    Aims: The aim of this study was to identify the immune- and locus-associated genes in pancreatic ductal adenocarcinoma and evaluate their value in prognosis. Methods: The pancreatic ductal adenocarcinoma stromal and immune scores were calculated with the estimation of stromal and immune cells in malignant tumor tissues using expression data algorithm. The authors screened the differentially expressed genes to generate immune- and stromal-related differentially expressed genes. Next, the authors conducted weighted correlation network analysis to find the gene sets related to tumor sites. Results:IL1R1 and LAMA2 were identified as the site- and immune-related genes in pancreatic ductal adenocarcinoma, and their high expression in pancreatic head cancer exhibited high immune scores and predicted unfavorable prognosis. Conclusion: The authors identified IL1R1 and LAMA2 as immune- and locus-associated genes, and their high expression predicted a poor prognosis.

    Lay abstract

    The prognosis of pancreatic cancer is poor, and pancreatic head carcinoma is different from pancreatic body/tail carcinoma in many respects. In recent years, the role of the immune microenvironment in tumors has been increasingly revealed. The authors wanted to find ways to improve the diagnosis and treatment of patients with pancreatic cancer by analyzing the key genes associated with different immune scores and pancreatic cancer sites. In the authors' study, IL1R1 and LAMA2 were identified as immune- and locus-associated genes, and their high expression predicted a poor prognosis, especially in pancreatic body/tail cancer. Early identification of high IL1R1 expression in pancreatic body/tail carcinoma may improve tumor prognosis.

    Papers of special note have been highlighted as: •• of considerable interest

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