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The intravenous to oral switch of taxanes: strategies and current clinical developments

    Marit AC Vermunt

    *Author for correspondence: Tel.: +31 20 512 2127;

    E-mail Address: m.vermunt@nki.nl

    Department of Pharmacy & Pharmacology, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands

    ,
    Andries M Bergman

    Department of Medical Oncology & Oncogenomics, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands

    ,
    Eric van der Putten

    Modra Pharmaceuticals BV, Barbara Strozzilaan 201, Amsterdam, 1083HN, The Netherlands

    &
    Jos H Beijnen

    Department of Pharmacy & Pharmacology, Netherlands Cancer Institute – Antoni van Leeuwenhoek, Plesmanlaan 121, Amsterdam, 1066CX, The Netherlands

    Modra Pharmaceuticals BV, Barbara Strozzilaan 201, Amsterdam, 1083HN, The Netherlands

    Department of Pharmaceutical Sciences, Utrecht University, Heidelberglaan 100, Utrecht, 3584CX, The Netherlands

    Published Online:https://doi.org/10.2217/fon-2020-0876

    The taxanes paclitaxel, docetaxel and cabazitaxel are important anticancer agents that are widely used as intravenous treatment for several solid tumor types. Switching from intravenous to oral treatment can be more convenient for patients, improve cost–effectiveness and reduce the demands of chemotherapy treatment on hospital care. However, oral treatment with taxanes is challenging because of pharmaceutical and pharmacological factors that lead to low oral bioavailability. This review summarizes the current clinical developments in oral taxane treatment. Intravenous parent drugs, strategies in the oral switch, individual agents in clinical trials, challenges and further perspectives on treatment with oral taxanes are subsequently discussed.

    Papers of special note have been highlighted as: •• of considerable interest

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