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The efficacy and safety of lenvatinib in the treatment of solid tumors: an up-to-date meta-analysis

    Wen jie Xie

    Department of General Surgery, Baoding First Central Hospital, Baoding, 071000, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Shuai Zhang

    Department of General Surgery, Baoding First Central Hospital, Baoding, 071000, China

    ‡Authors contributed equally

    Search for more papers by this author

    ,
    Lei Su

    Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, 071000, China

    ,
    Yan hong Li

    Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, 071000, China

    ,
    Xi Zhang

    Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, 071000, China

    &
    Yu ge Ran

    *Author for correspondence: Tel.: +86 0312 598 3232;

    E-mail Address: 13722957200@163.com

    Department of Radiotherapy, Affiliated Hospital of Hebei University, Baoding, 071000, China

    Published Online:https://doi.org/10.2217/fon-2020-0327

    Aim: We performed an updated meta-analysis to evaluate the efficacy and safety of lenvatinib in cancer patients. Materials & methods: Databases were searched to identify relevant trials. Data were extracted to evaluate overall survival, progression-free survival, overall response rate and grade ≥3 adverse events. Results: The pooled analysis demonstrated that lenvatinib significantly improved progression-free survival (hazard ratio: 0.43; 95% CI: 0.23–0.80; p = 0.008), overall survival (hazard ratio: 0.85; 95% CI: 0.75–0.97; p = 0.013) and overall response rate (relative risk: 6.89; 95% CI: 2.22–21.36; p = 0.001) compared with control therapy. However, the use of lenvatinib can increase the risk of severe infection. Conclusion: Lenvatinib-containing regimens are associated with better progression-free survival, overall survival and overall response rate, but can induce severe infection.

    Papers of special note have been highlighted as: • of interest

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