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Molecular landscape of pancreatic cancer: challenges and clinical implications

    Ioannis D Kyrochristos

    Centre for Biosystems & Genome Network Medicine, Ioannina University, Ioannina 45110, Greece

    Department of Surgery, Ioannina University Hospital, Ioannina 45500, Greece

    ,
    Demosthenes E Ziogas

    Centre for Biosystems & Genome Network Medicine, Ioannina University, Ioannina 45110, Greece

    Department of Surgery, ‘G Hatzikosta’ General Hospital, Ioannina 45001, Greece

    ,
    Georgios K Glantzounis

    Department of Surgery, Ioannina University Hospital, Ioannina 45500, Greece

    &
    Dimitrios H Roukos

    *Author for correspondence: Tel.: +30 265 100 557;

    E-mail Address: droukos@uoi.gr

    Centre for Biosystems & Genome Network Medicine, Ioannina University, Ioannina 45110, Greece

    Department of Surgery, Ioannina University Hospital, Ioannina 45500, Greece

    Biomedical Research Foundation of the Academy of Athens (BRFAA), Athens 11527, Greece

    Published Online:https://doi.org/10.2217/fon-2017-0335
    Free first page

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

    References

    • 1 Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J. Clin. 67(1), 7–30 (2017).
    • 2 Oettle H, Neuhaus P, Hochhaus A et al. Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial. JAMA 310(14), 1473–1481 (2013).
    • 3 Yu Z, Zhong W, Tan ZM, Wang LY, Yuan YH. Gemcitabine adjuvant therapy for resected pancreatic cancer: a meta-analysis. Am. J. Clin. Oncol. 38(3), 322–325 (2015).
    • 4 Kyrochristos ID, Glantzounis GK, Ziogas DE et al. From clinical standards to translating next-generation sequencing research into patient care improvement for hepatobiliary and pancreatic cancers. Int. J. Mol. Sci. 18(1), 180 (2017).
    • 5 National Comprehensive Cancer Network, Inc. www.nccn.org/
    • 6 Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature 489(7414), 57–74 (2012).
    • 7 Le DT, Uram JN, Wang H et al. PD-1 Blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372(26), 2509–2520 (2015).
    • 8 Nones K, Waddell N, Wayte N et al. Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nat. Commun. 5, 5224 (2014).
    • 9 Humphris JL, Patch AM, Nones K et al. Hypermutation in pancreatic cancer. Gastroenterology 152(1), 68–74; e62 (2017).
    • 10 Devarakonda S, Morgensztern D, Govindan R. Genomic alterations in lung adenocarcinoma. Lancet Oncol. 16(7), e342–e351 (2015).
    • 11 Prat A, Pineda E, Adamo B et al. Clinical implications of the intrinsic molecular subtypes of breast cancer. Breast 24(Suppl. 2), S26–S35 (2015).
    • 12 Waddell N, Pajic M, Patch AM et al. Whole genomes redefine the mutational landscape of pancreatic cancer. Nature 518(7540), 495–501 (2015).
    • 13 Connor AA, Denroche RE, Jang GH et al. Association of distinct mutational signatures with correlates of increased immune activity in pancreatic ductal adenocarcinoma. JAMA Oncol. 3(6), 774–783 (2017).
    • 14 Bailey P, Chang DK, Nones K et al. Genomic analyses identify molecular subtypes of pancreatic cancer. Nature 531(7592), 47–52 (2016).
    • 15 Collisson EA, Sadanandam A, Olson P et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat. Med. 17(4), 500–503 (2011).
    • 16 Hoadley KA, Yau C, Wolf DM et al. Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin. Cell 158(4), 929–944 (2014).
    • 17 Gundem G, Van Loo P, Kremeyer B et al. The evolutionary history of lethal metastatic prostate cancer. Nature 520(7547), 353–357 (2015).
    • 18 Eirew P, Steif A, Khattra J et al. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature 518(7539), 422–426 (2015).
    • 19 Yates LR, Gerstung M, Knappskog S et al. Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nat. Med. 21(7), 751–759 (2015).
    • 20 Hao JJ, Lin DC, Dinh HQ et al. Spatial intratumoral heterogeneity and temporal clonal evolution in esophageal squamous cell carcinoma. Nat. Genet. 48(12), 1500–1507 (2016).
    • 21 Zill OA, Greene C, Sebisanovic D et al. Cell-free DNA next-generation sequencing in pancreatobiliary carcinomas. Cancer Discov. 5(10), 1040–1048 (2015).
    • 22 Pishvaian MJ, Bender RJ, Matrisian LM et al. A pilot study evaluating concordance between blood-based and patient-matched tumor molecular testing within pancreatic cancer patients participating in the Know Your Tumor (KYT) initiative. Oncotarget 8, 83446–83456 (2017).
    • 23 Roukos DH. Spatiotemporal diversification of intrapatient genomic clones and early drug development concepts realize the roadmap of precision cancer medicine. Drug Discov. Today 22(8), 1148–1164 (2017).