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Recommendations for SIR-Spheres Y-90 resin microspheres in chemotherapy-refractory/intolerant colorectal liver metastases

    Enrique Aranda

    *Author for correspondence: Tel.: +34 957 736 231 (Secretary); +34 957 011 410 (Office);

    E-mail Address: earandaa@seom.org

    Department of Medical Oncology, Hospital Universitario Reina Sofía, CIBERONC, IMIBIC, UCO, Córdoba, Spain

    ,
    Jorge Aparicio

    Department of Medical Oncology, Hospital Universitari I Politecnic La Fe, Valencia, Spain

    ,
    José Ignacio Bilbao

    Department of Vascular & Interventional Radiology, Clínica Universidad de Navarra, Navarra, Spain

    ,
    Pilar García Alfonso

    Department of Medical Oncology, Hospital General Universitario Gregorio Marañón, Madrid, Spain

    ,
    Joan Maurel

    Department of Medical Oncology, Hospital Clinic, Barcelona, Spain

    ,
    Javier Rodríguez

    Department of Medical Oncology, Clínica Universitaria de Navarra, Navarra, Spain

    ,
    Bruno Sangro

    Liver Unit & HPB Oncology Area, Clínica Universitaria de Navarra-IDISNA-CIBEREHD, Pamplona, Spain

    ,
    José María Vieitez

    Department of Medical Oncology, Hospital Universitario Central de Asturias, Asturias, Spain

    &
    Jaime Feliu

    Department of Medical Oncology, Hospital Universitario La Paz, CIBERONC, Madrid, Spain

    Published Online:https://doi.org/10.2217/fon-2017-0220

    A Spanish expert panel reviewed current evidence for the use of SIR-Spheres Y-90 resin microspheres in patients with chemotherapy refractory/intolerant unresectable colorectal liver metastases. Substantial evidence for its efficacy and safety is available from a randomized controlled study, retrospective comparative studies and several single arm studies. Clinical evidence data obtained from more than 1500 patients have led to the inclusion of selective internal radiation therapy in the 2016 ESMO Clinical Guidelines as third-line treatment. This publication results from an expert panel meeting, where published evidence and author's experiences were shared to position SIR-Spheres Y-90 resin microspheres in Spain for the treatment of chemotherapy refractory/intolerant unresectable colorectal liver metastases, and second, to define the patient subgroup that will benefit the most with this treatment.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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