Review

Developmental hearing loss disrupts synaptic inhibition: implications for auditory processing

Anne E Takesian

Center for Neural Science, New York University, NY 10003, USA.

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Email the corresponding author at aet241@nyu.edu

Vibhakar C Kotak

Center for Neural Science, New York University, NY 10003, USA.

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Email the corresponding author at vck1@nyu.edu

Dan H Sanes

† Author for correspondence

Center for Neural Science & Department of Biology, New York University, NY 10003, USA.

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Email the corresponding author at sanes@cns.nyu.edu

Published Online:23 Apr 2009https://doi.org/10.2217/fnl.09.5

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Abstract

Hearing loss during development leads to central deficits that persist even after the restoration of peripheral function. One key class of deficits is due to changes in central inhibitory synapses, which play a fundamental role in all aspects of auditory processing. This review focuses on the anatomical and physiological alterations of inhibitory connections at several regions within the central auditory pathway following hearing loss. Such aberrant inhibitory synaptic function may be linked to deficits in encoding binaural and spectral cues. Understanding the cellular changes that occur at inhibitory synapses following hearing loss may provide specific loci that can be targeted to improve function.

Keywords:

Papers of special note have been highlighted as: ▪ of interest ▪▪ of considerable interest

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Published online 23 April 2009

Published in print May 2009

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Financial & competing interests disclosure

Supported by DC006864 (Dan H Sanes and Vibhakar C Kotak) and DC008920 (Anne E Takesian). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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