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L. plantarum and L. lactis as a promising agent in treatment of inflammatory bowel disease and colorectal cancer

    Hossein Javid

    Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran

    Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, 917966679, Iran

    ,
    Mahsa Akbari Oryani

    Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran

    ,
    Sanaz Akbari

    Department of Biology, Islamic Azad University, Mashhad Branch, Mashhad, 9133736351, Iran

    ,
    Taghi Amiriani

    Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, 4918936316, Iran

    ,
    Samaneh Ravanbakhsh

    Biology Expert, Plant Sciences, graduate of Golestan University, Gorgan, 4918936316, Iran

    ,
    Nastaran Rezagholinejad

    Department of Biochemistry, Payame Noor University (PNU), Mashhad, 193954697, Iran

    ,
    Amir-R Afshari

    Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, 9414974877, Iran

    &
    Mehdi Karimi-Shahri

    *Author for correspondence:

    E-mail Address: Labratorylabratory@yahoo.com

    Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, 1313199137, Iran

    Department of Pathology, School of Medicine, Gonabad University of Medical Sciences, Gonabad, 9691657678, Iran

    Published Online:https://doi.org/10.2217/fmb-2023-0076

    It has been understood for nearly a century that patients with intestinal inflammatory disease (IBD) have a higher risk of developing colorectal cancer (CRC). Recently, two species of lactic acid bacteria, Lactobacillus plantarum and Lactococcus lactis, have been investigated as therapeutic agents for IBD. These bacteria have been shown to survive gastric transit, to adhere and colonize in the intestinal tract of humans and modulate the intestinal microbiota and immune response. L. plantarum and L. lactis might be used as multifunctional drugs for the treatment of IBD and the prevention or treatment of CRC. This article summarizes current knowledge of L. plantarum and L. lactis as therapeutic and preventative agents for IBD and CRC, respectively.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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