Review

Evidence and speculation: the response of Salmonella confronted by autophagy in macrophages

Zhongyi Xie

Department of Biochemistry & Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, Jiangsu 212013, China

International Genome Center, Jiangsu University, Zhenjiang, Jiangsu 212013, China

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Ying Zhang

*Author for correspondence:

E-mail Address: zhangyingzj85@163.com

Department of Biochemistry & Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, Jiangsu 212013, China

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Xinxiang Huang

**Author for correspondence:

E-mail Address: huxinx@ujs.edu.cn

Department of Biochemistry & Molecular Biology, Jiangsu University School of Medicine, Zhenjiang, Jiangsu 212013, China

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Published Online:7 Oct 2020https://doi.org/10.2217/fmb-2020-0125

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Abstract

Bacteria of the Salmonella genus cause diseases ranging from self-limited gastroenteritis to typhoid fever. Macrophages are immune cells that engulf and restrict Salmonella. These cells will carry Salmonella into the circulatory system and provoke a systemic infection. Therefore, the interaction between macrophages and intracellular Salmonella is vital for its pathogenicity. As one of the immune responses of macrophages, autophagy, along with the fusion of autophagosomes with lysosomes, occupies an important position in eliminating Salmonella. However, Salmonella that can overcome cellular defensive responses and infect neighboring cells must derive strategies to escape autophagy. This review introduces novel findings on Salmonella and macrophage autophagy as a mechanism against infection and explores the strategies used by Salmonella to escape autophagy.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 15, No. 13

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History

Received 25 May 2020

Accepted 14 August 2020

Published online 7 October 2020

Published in print September 2020

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Keywords

Author contributions

Z Xie drafted the manuscript. Y Zhang and X Huang critically revised and approved the final manuscript.

Financial & competing interests disclosure

The work was funded by the National Natural Science Foundation of China (31670131), the China Postdoctoral Science Foundation funded project (2018M642186). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

English language editing for this manuscript was provided by International Science Editing (http://www.internationalscienceediting.com) and was funded by the National Natural Science Foundation of China (31670131).

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