Papers of special note have been highlighted as: • of interest; •• of considerable interest
References
- 1 Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 43(3), 304–377 (2017).
- 2 . Determinants of inappropriate empirical antibiotic treatment: systematic review and meta-analysis. Int. J. Antimicrob. Agents 51(4), 548–553 (2018). • An extensive evaluation of the impact of infections by multidrug-resistant organisms on patient's management and outcomes.
- 3 Effectiveness of practices to increase timeliness of providing targeted therapy for inpatients with bloodstream infections: a laboratory medicine best practices systematic review and meta-analysis. Clin. Microbiol. Rev. 29(1), 59–103 (2016). •• A comprehensive assessment of different fast microbiology workflows on pathogen identification and initiation of targeted therapy in bloodstream infections.
- 4 Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT international cohort study. Intensive Care Med. 38(12), 1930–1945 (2012).
- 5 . Rapid phenotypic methods to improve the diagnosis of bacterial bloodstream infections: meeting the challenge to reduce the time to result. Clin. Microbiol. Infect. 24(9), 935–943 (2018).
- 6 . Diagnosis of bloodstream infections from positive blood cultures and directly from blood samples: recent developments in molecular approaches. Clin. Microbiol. Infect. 24(9), 944–955 (2018). •• An exhaustive update on recent developments of molecular methods in the diagnosis of bloodstream infections.
- 7 . Molecular antibiogram in diagnostic clinical microbiology: advantages and challenges. Future Microbiol. 12, 361–364 (2017).
- 8 Cumulative effect of an antimicrobial stewardship and rapid diagnostic testing bundle on early streamlining of antimicrobial therapy in gram-negative bloodstream infections. Antimicrob. Agents Chemother. 61(9), e00189–17 (2017).
- 9 Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin. Infect. Dis. 62(10), e51–e77 (2016).
- 10 The GISA call to action for the appropriate use of antimicrobials and the control of antimicrobial resistance in Italy. Int. J. Antimicrob. Agents. 52(2), 127–134 (2018).
- 11 US Food and Drug Association. Companion Diagnostics (2018). www.fda.gov/MedicalDevices/ProductsandMedicalProcedures/InVitroDiagnostics/ucm407297.htm.
- 12 . Implementation of rapid molecular infectious disease diagnostics: the role of diagnostic and antimicrobial stewardship. J. Clin. Microbiol. 55(3), 715–723 (2017). •• An overview of features and aims of diagnostic stewardship and its connection to antimicrobial stewardship.
- 13 Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Crit. Care Med. 26(11), 1793–1800 (1998).
- 14 Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am. J. Epidemiol. 173(6), 676–682 (2011).
- 15 The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA 315(8), 801–810 (2016).
- 16 Predictors of outcome in patients with severe sepsis or septic shock due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Int. J. Antimicrob. Agents 52(5), 577–585 (2018).
- 17 Scoring systems for prediction of mortality in patients with intensive care unit-acquired sepsis: a comparison of the PITT bacteremia score and the Acute Physiology and Chronic Health Evaluation II scoring systems. Shock 31(2), 146–150 (2009).
- 18 . Diagnostic efficacy of serum procalcitonin, C-reactive protein concentration and clinical pulmonary infection score in ventilator-associated pneumonia. Med. Sci. 34, 26–32 (2018).
- 19 Medical wards invasive candidiasis algorithms (MEDICAL): consensus proposal for management. Eur. J. Intern. Med. 34, 45–53 (2016).
- 20 . Carbapenem-resistant Enterobacteriaceae colonization and infection in critically ill patients: a retrospective matched cohort comparison with non-carriers. J. Hosp. Infect. 94(1), 54–59 (2016). • Clinical study assessing the association of carbapenem-resistant Enterobacterales colonization with the risk of infection by the colonizing strain.
- 21 Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials. Crit. Care 22(1), 191 (2018).
- 22 Procalcitonin-guided antibiotic therapy: an expert consensus. Clin. Chem. Lab. Med. 56(8), 1223–1229 (2018).
- 23 . Mid regional pro-adrenomedullin for the prediction of organ failure in infection. Results from a single centre study. PLoS ONE 13(8), e0201491 (2018). • Clinical study on the ability of the novel biomarker mid-regional proadrenomedullin in predicting the evolution to sepsis of infected patients in intensive care unit.
- 24 Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions. Lancet Infect. Dis. 14(6), 498–509 (2014).