References
- 1. . Parkinson's disease. Lancet 397(10291), 2284–2303 (2021).
- 2. . Distinctive patterns of DNA methylation associated with Parkinson's disease: identification of concordant epigenetic changes in brain and peripheral blood leukocytes. Epigenetics 8(10), 1030–1038 (2013).
- 3. . Methylation regulates alpha-synuclein Expression and is decreased in Parkinson's disease patients' brains. J. Neurosci. 30(18), 6355–6359 (2010).
- 4. . Hypomethylation of intron1 of α-synuclein gene does not correlate with Parkinson's disease. Mol. Brain 10(1), 6 (2017).
- 5. DNA methylation of the 5′-UTR DAT 1 gene in Parkinson's disease patients. Acta Neurol. Scand. 142(3), 275–280 (2020).
- 6. A DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons. CNS Neurosci. Ther. 19(3), 183–190 (2013).
- 7. TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease. Hum. Mol. Genet. 29(8), 1239–1252 (2020).
- 8. . Regulation of alpha-synuclein gene (SNCA) by epigenetic modifier TET1 in Parkinson disease. Int. Neurourol. J. 26(Suppl. 2), S85–S93 (2022).
- 9. L-dopa increases α-synuclein DNA methylation in Parkinson's disease patients in vivo and in vitro: L-Dopa and SNCA DNA methylation. Mov. Disord. 30(13), 1794–1801 (2015).
- 10. . Genome-wide histone acetylation analysis reveals altered transcriptional regulation in the Parkinson's disease brain. Mol. Neurodegener. 16(1), 31 (2021).
- 11. . Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum. Mol. Genet. 15(20), 3012–3023 (2006).
- 12. . Regulation of histone acetylation by autophagy in Parkinson's disease. J. Biol. Chem. 291(7), 3531–3540 (2016).
- 13. Histone deacetylase 4 inhibition reduces rotenone-induced alpha-synuclein accumulation via autophagy in SH-SY5Y cells. Brain Sci. 13(4), 670 (2023).
- 14. . Histone deacetylase 6 and the disease mechanisms of α-synucleinopathies. Front. Synaptic Neurosci. 12, 586453 (2020).
- 15. Histone deacetylases as epigenetic targets for treating Parkinson's disease. Brain Sci. 12(5), 672 (2022).
- 16. . Altered long noncoding RNA expression precedes the course of Parkinson's disease-a preliminary report. Mol. Neurobiol. 54(4), 2869–2877 (2017).
- 17. Salivary microR-153 and microR-223 levels as potential diagnostic biomarkers of idiopathic Parkinson's disease. Mov. Disord. 35(3), 468–477 (2020).
- 18. miR-335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease. Int. J. Mol. Med. 47(4), 61 (2021).
- 19. . Long non-coding RNA NEAT1 mediates the toxic of Parkinson's disease induced by MPTP/MPP+ via regulation of gene expression. Clin. Exp. Pharmacol. Physiol. 45(8), 841–848 (2018).
- 20. . circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR-29c-3p-mediated AMPK/mTOR pathway in Parkinson's disease. Mol. Med. Rep. 24(1), 540 (2021).