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Cataloging recent advances in epigenetic alterations in major mental disorders and autism

    Hamid Mostafavi Abdolmaleky

    *Author for correspondence:

    E-mail Address: hamostafavi@yahoo.com

    Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, 02118 MA, USA

    Department of Surgery, Nutrition/Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02215 MA, USA

    ,
    Jin-Rong Zhou

    Department of Surgery, Nutrition/Metabolism Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, 02215 MA, USA

    &
    Sam Thiagalingam

    Department of Medicine (Biomedical Genetics), Boston University School of Medicine, Boston, 02118 MA, USA

    Genetics & Genomics Graduate Program, Boston University School of Medicine, Boston, 02118 MA, USA

    Department of Pathology & Laboratory Medicine, Boston University School of Medicine, Boston, 02218 MA, USA

    Published Online:https://doi.org/10.2217/epi-2021-0074

    During the last two decades, diverse epigenetic modifications including DNA methylation, histone modifications, RNA editing and miRNA dysregulation have been associated with psychiatric disorders. A few years ago, in a review we outlined the most common epigenetic alterations in major psychiatric disorders (e.g., aberrant DNA methylation of DTNBP1, HTR2A, RELN, MB-COMT and PPP3CC, and increased expression of miR-34a and miR-181b). Recent follow-up studies have uncovered other DNA methylation aberrations affecting several genes in mental disorders, in addition to dysregulation of many miRNAs. Here, we provide an update on new epigenetic findings and highlight potential origin of the diversity and inconsistencies, focusing on drug effects, tissue/cell specificity of epigenetic landscape and discuss shortcomings of the current diagnostic criteria in mental disorders.

    Papers of special note have been highlighted as: • of interest; •• of considerable interest

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