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Causes and risk factors

    Barbara Wirostko

    Barbara Wirostko, MD, is a board-certified ophthalmologist and fellowship-trained glaucoma specialist. She maintains an academic research and clinical practice with the University of Utah, Moran Eye Center (USA), as a Clinical Adjunct Associate Professor in ophthalmology. She is intimately involved with drug development and discovery in ophthalmology. She serves on various editorial boards, scientific advisory boards and glaucoma research foundations. From 2006 to 2010, she was Senior Medical Director within the specialty division at Pfizer (NY, USA). She oversaw the development of pipeline glaucoma strategy and led the Sustained Release Xalatan program, which is now in clinical trials. She has served as Principle Investigator for various glaucoma clinical trials. She completed her glaucoma fellowship at Cornell University (NY, USA) and received her ophthalmology training as well as her MD at Columbia University (NY, USA). Her BA with distinction was from Cornell University. She is a fellow of the American Academy of Ophthalmology, a member of the Association for Research in Vision and Ophthalmology, Women in Ophthalmology and local state societies.

    &
    Steven M Christiansen

    Steven M Christiansen, MD, obtained a BSc degree in business management from Brigham Young University (UT, USA) and earned a medical degree from the University of Utah School of Medicine (UT, USA). He has authored ten peer-reviewed articles in the areas of cornea and refractive surgery, presented at multiple national meetings and authored 15 textbook chapters on various aspects of pediatric ophthalmology and uveal tract disorders. He will soon begin internship at Indiana University Health Methodist Hospital (USA) and will then complete ophthalmology residency training at the University of Iowa (USA).

    Published Online:https://doi.org/10.2217/ebo.12.292
    Abstract:

    Glaucoma is a slowly progressive optic neuropathy characterized by damage to retinal ganglion nerve fibers of the optic nerve, which is sufficient to cause visual impairment. The disease can be categorized broadly into two categories: open-angle and narrow-angle glaucoma, both of which may be due to primary or secondary causes [1]. This chapter will discuss the various causes and risk factors of the more common types of glaucoma.

    References

    • Quigley HA . Glaucoma . Lancet 377 , 1367 – 1377 (2011) .
    • Quigley HA , Vitale S . Models of open-angle glaucoma prevalence and incidence in the United States . Invest. Ophthalmol. Vis. Sci. 38 , 83 – 91 (1997) .
    • Friedman DS , Wolfs RC , O’Colmain BJ et al. Prevalence of open-angle glaucoma among adults in the United States . Arch. Ophthalmol. 122 , 532 – 538 (2004) .
    • Tielsch JM , Sommer A , Katz J , Royall RM , Quigley HA , Javitt J . Racial variations in the prevalence of primary open-angle glaucoma: the Baltimore eye survey . JAMA 266 , 369 – 374 (1991) .
    • Boland MV , Quigley HA . Risk factors and open-angle glaucoma: classification and application . J. Glaucoma (2007) .
    • Acott TS , Kelly MJ . Extracellular matrix in the trabecular meshwork . Exp. Eye Res. 86 , 543 – 561 (2008) .
    • Vajaranant TS , Nayak S , Wilensky JT , Joslin CE . Gender and glaucoma: what we know and what we need to know . Curr. Opin. Ophthalmol. 21 , 91 – 99 (2010) .
    • Leske N , Connell AM , Schachat AP , Hyman L . The Barbados eye study: prevalence of open-angle glaucoma . Arch. Ophthalmol. 112 , 821 – 829 (1994) .
    • Sommer A , Tielsch JM , Katz J et al. Racial differences in the cause-specific prevalence of blindness in east Baltimore . N. Engl. J. Med. 325 , 1412 – 1417 (1991) .
    • 10  Cook C , Foster P . Epidemiology of glaucoma: what’s new? Can. J. Ophthalmol. 47 , 223 – 226 (2012) .
    • 11  Stein JD , Kim DS , Niziol LM . Differences in rates of glaucoma among Asian Americans and other racial groups, and among various Asian ethnic groups . Ophthalmology 118 , 1031 – 1037 (2011) .
    • 12  Summanen P , Tönjum AM . Exfoliation syndrome among Saudis . Acta Ophthalmol. Suppl. 184 , 107 – 111 (1988) .
    • 13  Wang X , Harmon J , Zabrieskie N et al. Using the Utah population database to assess familial risk of primary open angle glaucoma . Vision Res. 50 , 2391 – 2395 (2010) .
    • 14  Fingert JH , Stone EM , Sheffield VC et al. Myocilin glaucoma . Surv. Ophthalmol. 47 , 547 – 561 (2002) .
    • 15  Alward WL , Kwon YH , Kawase K et al. Evaluation of optineurin sequence variations in 1,048 patients with open-angle glaucoma . Am. J. Ophthalmol. 136 , 904 – 909 (2003) .
    • 16  Vickers JC , Craig JE , Stankovich J et al. The apolipoprotein ε4 gene is associated with elevated risk of normal tension glaucoma . Mol. Vis. 8 , 389 – 393 (2002) .
    • 17  Koga T , Shen X , Park JS et al. Differential effects of myocilin and optineurin, two glaucoma genes, on neurite outgrowth . Am. J. Pathol. 176 , 343 – 352 (2010) .
    • 18  Amerasinghe N , Zhang J , Thalamuthu A et al. The heritability and sibling risk of angle closure in Asians . Ophthalmology 118 , 480 – 485 (2011) .
    • 19  Chen H , Chen LJ , Zhang M et al. Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma . Mol. Vis. 16 , 167 – 177 (2010) .
    • 20  Sommer A , Tielsch JM , Katz J et al. Relationship between intraocular pressure and primary open angle glaucoma among white and black Americans. The Baltimore eye survey . Arch. Ophthalmol. 109 , 1090 – 1095 (1991) .
    • 21  Mitchell P , Smith W , Attebo K , Healey PR . Prevalence of open-angle glaucoma in Australia. The Blue Mountains eye study . Ophthalmology 103 , 1661 – 1669 (1996) .
    • 22  Gordon MO , Beiser JA , Brandt JD et al. The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma . Arch. Ophthalmol. 120 , 714 – 720 (2002) .
    • 23  Asrani S , Zeimer R , Wilensky J , Gieser D , Vitale S , Lindenmuth K . Large diurnal fluctuations in intraocular pressure are an independent risk factor in patients with glaucoma . J. Glaucoma 9 , 134 – 142 (2000) .
    • 24  Caprioli J , Coleman AL . Intraocular pressure fluctuation a risk factor for visual field progression at low intraocular pressures in the advanced glaucoma intervention study . Ophthalmology 115 , 1123 – 1129 (2008) .
    • 25  Jonas JB , Stroux A , Velten I et al. Central corneal thickness correlated with glaucoma damage and rate of progression . Invest. Ophthalmol. Vis. Sci. 46 , 1269 – 1274 (2005) .
    • 26  Medeiros FA , Weinreb RN . Is corneal thickness an independent risk factor for glaucoma? Ophthalmology 119 , 435 – 436 (2012) .
    • 27  Marcus MW , de Vries MM , Junoy Montolio FG et al. Myopia as a risk factor for open-angle glaucoma: a systematic review and meta-analysis . Ophthalmology 118 , 1989 – 1994 (2011) .
    • 28  Yanagi M , Kawasaki R , Wang JJ et al. Vascular risk factors in glaucoma: a review . Clin. Exp. Ophthalmol. 39 , 252 – 258 (2011) .
    • 29  Klein BE , Klein R , Knudtson MD . Intraocular pressure and systemic blood pressure: longitudinal perspective: the Beaver Dam Eye Study . Br. J. Ophthalmol. 89 , 284 – 287 (2005) .
    • 30  Konstas AG , Mikropoulos DG , Irkec M . Open-angle glaucoma and ocular perfusion . Br. J. Ophthalmol. 94 , 1273 – 1274 (2010) .
    • 31  Costa VP , Arcieri ES , Harris A . Blood pressure and glaucoma . Br. J. Ophthalmol. 93 , 1276 – 1282 (2009) .
    • 32  Zheng Y , Wong TY , Mitchell P , Friedman DS , He M , Aung T . Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the Singapore Malay eye study . Invest. Ophthalmol. Vis. Sci. 51 , 3399 – 3404 (2010) .
    • 33  Wang YX , Hu LN , Yang H , Jonas JB , Xu L . Frequency and associated factors of structural progression of open-angle glaucoma in the Beijing eye study . Br. J. Ophthalmol. 96 , 811 – 815 (2012) .
    • 34  Teng CC , De Moraes CG , Prata TS , Tello C , Ritch R , Liebmann JM . β-zone parapapillary atrophy and the velocity of glaucoma progression . Ophthalmology 117 , 909 – 915 (2010) .
    • 35  Prata TS , De Moraes CG , Teng CC , Tello C , Ritch R , Liebmann JM . Factors affecting rates of visual field progression in glaucoma patients with optic disc hemorrhage . Ophthalmology 117 , 24 – 29 (2010) .
    • 36  Medeiros FA , Zangwill LM , Mansouri K , Lisboa R , Tafreshi A , Weinreb RN . Incorporating risk factors to improve the assessment of rates of glaucomatous progression . Invest. Ophthalmol. Vis. Sci. 53 , 2199 – 2207 (2012) .
    • 37  Klein BE , Klein R , Jensen SC . Open-angle glaucoma and older-onset diabetes. The Beaver Dam eye study . Ophthalmology 101 , 1173 – 1177 (1994) .
    • 38  Dielemans I , de Jong PT , Stolk R , Vingerling JR , Grobbee DE , Hofman A . Primary open-angle glaucoma, intraocular pressure, and diabetes mellitus in the general elderly population. The Rotterdam study . Ophthalmology 103 , 1271 – 1275 (1996) .
    • 39  Woo S , Lee S , Park C et al. Elevated intraocular pressure is associated with insulin resistance and metabolic syndrome . Diabetes Metab. Res. Rev. 21 , 434 – 440 (2005) .
    • 40  Tan GS , Wong TY , Fong CW , Aung T . Diabetes, metabolic abnormalities, and glaucoma . Arch. Ophthalmol. 127 , 1354 – 1361 (2009) .
    • 41  Mitchell P , Lee AJ , Rochtchina E , Wang JJ . Open- angle glaucoma and systemic hypertension: the Blue Mountains eye study . J. Glaucoma 13 , 319 – 326 (2004) .
    • 42  Leske MC , Wu SY , Hennis A , Honkanen R , Nemesure B . Risk factors for incident open-angle glaucoma: the Barbados eye studies . Ophthalmology 115 , 85 – 93 (2008) .
    • 43  Kaiser HJ , Flammer J , Graf T , Stumpfig D . Systemic blood pressure in glaucoma patients . Graefes Arch. Clin. Exp. Ophthalmol. 231 , 677 – 680 (1993) .
    • 44  Demailly P , Cambien F , Plouin PF , Baron P , Chevallier B . Do patients with low tension glaucoma have particular cardiovascular characteristics? Ophthalmologica 188 , 65 – 75 (1984) .
    • 45  Abdala H , Pizzimentia JJ , Purvis CC et al. The eye in sleep apnea syndrome . Sleep Med. 7 , 107 – 115 (2006) .
    • 46  Mojon DS , Hess CW , Goldblum D et al. High prevalence of glaucoma in patients with sleep apnea syndrome . Ophthalmology 106 , 1009 – 1012 (1999) .
    • 47  Davies JR , Rudd JH , Weissberg PL . Molecular and metabolic imaging of atherosclerosis . J. Nucl. Med. 45 , 1898 – 1907 (2004) .
    • 48  Stein JD , Newman-Casey PA , Talwar N . The relationship between statin use and open-angle glaucoma . Ophthalmology (2012) .
    • 49  Moore D , Harris A , Wu D et al. Dysfunctional regulation of ocular blood flow: a risk factor for glaucoma? Clin. Ophthalmol. 2 , 849 – 861 (2008) .
    • 50  Drance S , Anderson D , Schulzer M . Risk factors for progression of visual field abnormalities in normal-tension glaucoma . Am. J. Ophthalmol. 131 , 699 – 708 (2001) .
    • 51  Cursiefen C , Wisse M , Cursiefen S et al. Migraine and tension headache in high-pressure and normal-pressure glaucoma . Am. J. Ophthalmol. 129 , 102 – 104 (2000) .
    • 52  McKendrick AM , Vingrys AJ , Badcock DR et al. Visual field losses in subjects with migraine headaches . Invest. Ophthalmol. Vis. Sci. 41 , 1239 – 1247 (2000) .
    • 53  Chauhan BC , Mikelberg FS , Balaszi AG . Canadian Glaucoma Study: 2. Risk factors for the progression of open-angle glaucoma . Arch. Ophthalmol. 126 , 1030 – 1036 (2008) .
    • 54  Wostyn P , Audenaert K , De Deyn PP . Alzheimer’s disease and glaucoma: is there a causal relationship? Br. J. Ophthalmol. 93 , 1557 – 1559 (2009) .

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