Methods of rapid diagnosis for the etiology of meningitis in adults

Papers of special note have been highlighted as: • of interest; •• of considerable interest.

References

• 1 Bhimraj A. Acute community-acquired bacterial meningitis in adults: an evidence-based review. Cleve. Clin. J. Med. 79(6), 393–400 (2012).
  MedlineGoogle Scholar
• 2 Brouwer MC, Thwaites GE, Tunkel AR, van de Beek D. Dilemmas in the diagnosis of acute community-acquired bacterial meningitis. Lancet 380(9854), 1684–1692 (2012).
  MedlineGoogle Scholar
• 3 Ersoy Y, Yetkin F, Bayraktar MR, Ersoy Y, Yologlu S. A new diagnostic scoring for discrimination of tuberculous and bacterial meningitis on the basis of clinical and laboratory findings. Med. Princ. Pract. 21(3), 259–263 (2012).
  MedlineGoogle Scholar
• 4 Thigpen MC, Whitney CG, Messonnier NE et al. Bacterial meningitis in the United States, 1998–2007. N. Engl. J. Med. 364(21), 2016–2025 (2011).
  Medline CASGoogle Scholar
• 5 Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin. Microbiol. Rev. 23(3), 467–492 (2010).
  Medline CASGoogle Scholar
• 6 Tuppeny M. Viral meningitis and encephalitis. Crit. Care Nurs. Clin. North Am. 25(3), 363–380 (2013).
  MedlineGoogle Scholar
• 7 James SH, Kimberlin DW, Whitley RJ. Antiviral therapy for herpesvirus central nervous system infections: neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection. Antiviral Res. 83(3), 207–213 (2009).
  Medline CASGoogle Scholar
• 8 Thwaites GE, van Toorn R, Schoeman J. Tuberculous meningitis: more questions, still too few answers. Lancet Neurol. 12(10), 999–1010 (2013).
  Medline CASGoogle Scholar
• 9 Rajasingham R, Rolfes MA, Birkenkamp KE, Meya DB, Boulware DR. Cryptococcal meningitis treatment strategies in resource-limited settings: a cost–effectiveness analysis. PLoS Med. 9(9), e1001316 (2012).
  MedlineGoogle Scholar
• 10 Marais S, Pepper DJ, Schutz C, Wilkinson RJ, Meintjes G. Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS ONE 6(5), e20077 (2011).
  Medline CASGoogle Scholar
• 11 Cohn AC, MacNeil JR, Harrison LH et al. Changes in Neisseria meningitidis disease epidemiology in the United States, 1998–2007: implications for prevention of meningococcal disease. Clin. Infect. Dis. 50(2), 184–191 (2010).
  MedlineGoogle Scholar
• 12 Hsu HE, Shutt KA, Moore MR et al. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N. Engl. J. Med. 360(3), 244–256 (2009).
  Medline CASGoogle Scholar
• 13 Miller E, Andrews NJ, Waight PA, Slack MP, George RC. Herd immunity and serotype replacement 4 years after seven-valent pneumococcal conjugate vaccination in England and Wales: an observational cohort study. Lancet Infect. Dis. 11(10), 760–768 (2011).
  Medline CASGoogle Scholar
• 14 National Institute for Communicable Diseases. Group for enteric, respiratory and meningeal disease surveillance in South Africa. In: GERMS-SA Annual Report 2012. Meiring S, Quan V, Govender N, Crowther-Gibson P (Eds). Johannesburg, South Africa (2012).
  Google Scholar
• 15 Gessner BD, Mueller JE, Yaro S. African meningitis belt pneumococcal disease epidemiology indicates a need for an effective serotype 1 containing vaccine, including for older children and adults. BMC Infect. Dis. 10, 22 (2010).
  MedlineGoogle Scholar
• 16 McIntyre PB, O'Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet 380(9854), 1703–1711 (2012).
  MedlineGoogle Scholar
• 17 Coulson GB, von Gottberg A, du Plessis M et al. Meningococcal disease in South Africa, 1999–2002. Emerg. Infect. Dis. 13(2), 273–281 (2007).
  MedlineGoogle Scholar
• 18 Mohammed I, Nasidi A, Alkali AS et al. A severe epidemic of meningococcal meningitis in Nigeria, 1996. Trans. R. Soc. Trop. Med. Hyg. 94(3), 265–270 (2000).
  Medline CASGoogle Scholar
• 19 Daugla DM, Gami JP, Gamougam K et al. Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community study. Lancet 383(9911), 40–47 (2014).•• Demonstrates the elimination of meningococcal meningitis serotype A and carriage with community-wide vaccination. Ongoing implementation of vaccination will likely greatly decrease the burden of meningococcal disease in the meningitis belt of Africa.
  Medline CASGoogle Scholar
• 20 Zipursky S, Djingarey MH, Lodjo J-C, Olodo L, Tiendrebeogo S, Ronveaux O. Benefits of using vaccines out of the cold chain: delivering meningitis A vaccine in a controlled temperature chain during the mass immunization campaign in Benin. Vaccine 32(13), 1431–1435 (2014).
  MedlineGoogle Scholar
• 21 Ladhani S, Slack MP, Heys M, White J, Ramsay ME. Fall in Haemophilus influenzae serotype b (Hib) disease following implementation of a booster campaign. Arch. Dis. Child. 93(8), 665–669 (2008).
  Medline CASGoogle Scholar
• 22 Schrag SJ, Zywicki S, Farley MM et al. Group B streptococcal disease in the era of intrapartum antibiotic prophylaxis. N. Engl. J. Med. 342(1), 15–20 (2000).
  Medline CASGoogle Scholar
• 23 Phares CR, Lynfield R, Farley MM et al. Epidemiology of invasive group B streptococcal disease in the United States, 1999–2005. JAMA 299(17), 2056–2065 (2008).
  Medline CASGoogle Scholar
• 24 World Health Organisation. Global Tuberculosis Report – 2012. 1–6 (2012).
  Google Scholar
• 25 Riddell JT, Shuman EK. Epidemiol. Centr. Nerv. Syst. Infect. Neuroimag. Clin. N. Am. 22(4), 543–556 (2012).
  MedlineGoogle Scholar
• 26 Berenguer J, Moreno S, Laguna F et al. Tuberculous meningitis in patients infected with the human immunodeficiency virus. N. Engl. J. Med 326(10), 668–672 (1992).
  Medline CASGoogle Scholar
• 27 Jarvis JN, Meintjes G, Williams A, Brown Y, Crede T, Harrison TS. Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. BMC Infect. Dis. 10, 67 (2010).• Reports the etiologies of adult meningitis in Cape Town, South Africa reflecting the impact of HIV has had on the etiologies of meningitis.
  MedlineGoogle Scholar
• 28 Woldeamanuel YW, Girma B. A 43-year systematic review and meta-analysis: case-fatality and risk of death among adults with tuberculous meningitis in Africa. J. Neurol. 261(5), 851–865 (2013).
  MedlineGoogle Scholar
• 29 CDC. Emergence of Cryptococcus gattii – Pacific Northwest, 2004–2010. Morbid. Mortal. Wkly. Rep. 59(28), 865–868 (2010).
  MedlineGoogle Scholar
• 30 Ecevit IZ, Clancy CJ, Schmalfuss IM, Nguyen MH. The poor prognosis of central nervous system cryptococcosis among nonimmunosuppressed patients: a call for better disease recognition and evaluation of adjuncts to antifungal therapy. Clin. Infect. Dis. 42(10), 1443–1447 (2006).
  MedlineGoogle Scholar
• 31 Loyse A, Wilson D, Meintjes G et al. Comparison of the early fungicidal activity of high-dose fluconazole, voriconazole, and flucytosine as second-line drugs given in combination with amphotericin B for the treatment of HIV-associated cryptococcal meningitis. Clin. Infect. Dis. 54(1), 121–128 (2012).
  Medline CASGoogle Scholar
• 32 Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23(4), 525–530 (2009).
  MedlineGoogle Scholar
• 33 Cohen DB, Zijlstra EE, Mukaka M et al. Diagnosis of cryptococcal and tuberculous meningitis in a resource-limited African setting. Trop. Med. Int. Health 15(8), 910–917 (2010).
  MedlineGoogle Scholar
• 34 National Institute for Communicable Diseases. Group for Enteric, Respiratory and Meningeal Disease Surveillance in South Africa (GERMS-SA). In: GERMS-SA Annual Report 2011. Govender N, Quan V (Eds). Johannesburg, South Africa (2011).
  Google Scholar
• 35 Smith RM, Schaefer MK, Kainer MA et al. Fungal infections associated with contaminated methylprednisolone injections. N. Engl. J. Med. 369(17), 1598–1609 (2013).
  Medline CASGoogle Scholar
• 36 Johnson RH, Einstein HE. Coccidioidal meningitis. Clin. Infect. Dis. 42(1), 103–107 (2006).
  MedlineGoogle Scholar
• 37 Bariola JR, Perry P, Pappas PG et al. Blastomycosis of the central nervous system: a multicenter review of diagnosis and treatment in the modern era. Clin. Infect. Dis. 50(6), 797–804 (2010).
  MedlineGoogle Scholar
• 38 Wheat LJ, Batteiger BE, Sathapatayavongs B. Histoplasma capsulatum infections of the central nervous system. Clin. Rev. Med. 69(4), 244–260 (1990).
  CASGoogle Scholar
• 39 Rotbart HA, Brennan PJ, Fife KH et al. Enterovirus meningitis in adults. Clin. Infect. Dis. 27(4), 896–898 (1998).
  Medline CASGoogle Scholar
• 40 Kupila L, Vuorinen T, Vainionpaa R, Hukkanen V, Marttila RJ, Kotilainen P. Etiology of aseptic meningitis and encephalitis in an adult population. Neurology 66(1), 75–80 (2006).
  Medline CASGoogle Scholar
• 41 Lee BE, Davies HD. Aseptic meningitis. Curr. Opin. Infect. Dis. 20(3), 272–277 (2007).
  MedlineGoogle Scholar
• 42 Soares CN, Cabral-Castro MJ, Peralta JM, de Freitas MR, Zalis M, Puccioni-Sohler M. Review of the etiologies of viral meningitis and encephalitis in a dengue endemic region. J. Neurol. Sci. 303(1–2), 75–79 (2011).
  MedlineGoogle Scholar
• 43 Rajasingham R, Meya DB, Boulware DR. Integrating cryptococcal antigen screening and pre-emptive treatment into routine HIV care. J. Acquire. Immune Defic. Syndr. 59(5), e85–e91 (2012).
  Medline CASGoogle Scholar
• 44 Thwaites GE. Advances in the diagnosis and treatment of tuberculous meningitis. Curr. Opin. Neurol. 26(3), 295–300 (2013).
  Medline CASGoogle Scholar
• 45 Bekondi C, Bernede C, Passone N et al. Primary and opportunistic pathogens associated with meningitis in adults in Bangui, Central African Republic, in relation to human immunodeficiency virus serostatus. Int. J. Infect. Dis. 10(5), 387–395 (2006).
  MedlineGoogle Scholar
• 46 Domingo P, Suarez-Lozano I, Torres F et al. Bacterial meningitis in HIV-1-infected patients in the era of highly active antiretroviral therapy. J. Acq. Immune Defic. Syndr. 51(5), 582–587 (2009).
  MedlineGoogle Scholar
• 47 Durski KN, Kuntz KM, Yasukawa K, Virnig BA, Meya DB, Boulware DR. Cost-effective diagnostic checklists for meningitis in resource-limited settings. J. Acq. Immune Defic. Syndr. 63(3), e101–e108 (2013).•• Proposes a diagnostic algorithm for meningitis in sub-Saharan Africa among populations with high prevalence of HIV. The use of cost–effectiveness has been minimal to date in the realm of infectious disease diagnostics, and this study demonstrates a decrease in healthcare costs while improving diagnostic accuracy with the use of stepwise and targeted testing.
  MedlineGoogle Scholar
• 48 Bahr N, Boulware DR, Marais S, Scriven J, Wilkinson RJ, Meintjes G. Central nervous system immune reconstitution inflammatory syndrome. Curr. Infect. Dis. Rep. 15(6), 583–593 (2013).
  MedlineGoogle Scholar
• 49 Meya DB, Manabe YC, Castelnuovo B et al. Cost–effectiveness of serum cryptococcal antigen screening to prevent deaths among HIV-infected persons with a CD4+ cell count < or = 100 cells/microL who start HIV therapy in resource-limited settings. Clin. Infect. Dis. 51(4), 448–455 (2010).
  MedlineGoogle Scholar
• 50 Newland A, Provan D, Myint S. Preventing severe infection after splenectomy. BMJ 331(7514), 417–418 (2005).
  MedlineGoogle Scholar
• 51 Adriani KS, Brouwer MC, van der Ende A, van de Beek D. Bacterial meningitis in adults after splenectomy and hyposplenic states. Mayo Clin. Proc. 88(6), 571–578 (2013).
  MedlineGoogle Scholar
• 52 Martinot M, Oswald L, Parisi E et al. Immunoglobulin deficiency in patients with Streptococcus pneumoniae or Haemophilus influenzae invasive infections. Int. J. Infect. Dis. 19, 79–84 (2014).
  Medline CASGoogle Scholar
• 53 Domingo P, Barquet N, Alvarez M, Coll P, Nava J, Garau J. Group B streptococcal meningitis in adults: report of twelve cases and review. Clin. Infect. Dis. 25(5), 1180–1187 (1997).
  Medline CASGoogle Scholar
• 54 Brouwer MC, van de Beek D, Heckenberg SG, Spanjaard L, de Gans J. Community-acquired Listeria monocytogenes meningitis in adults. Clin. Infect. Dis. 43(10), 1233–1238 (2006).
  MedlineGoogle Scholar
• 55 Cabellos C, Viladrich PF, Ariza J, Maiques JM, Verdaguer R, Gudiol F. Community-acquired bacterial meningitis in cirrhotic patients. Clin. Microbiol. Infect. 14(1), 35–40 (2008).
  Medline CASGoogle Scholar
• 56 Castro Marquez C, Castro Laria L, Arguelles Arias F, Herrerias JM. Residual hydrocephalus after tuberculous meningitis in a patient with biological therapy. Inflamm. Bowel Dis. 17(6), E33–E34 (2011).
  MedlineGoogle Scholar
• 57 Girardi K, Paviglianiti A, Cirillo M et al. Tuberculous meningoencephalitis in a patient with hairy cell leukemia in complete remission. J. Clin. Exp. Hematopathol. 52(1), 31–34 (2012).
  Medline CASGoogle Scholar
• 58 Petramfar P, Yousefian M, Ashraf MH, Davarpanah MA, Rahmati H. Meningoencephalitis with Aspergillus and Mycobacterium tuberculosis in a renal transplant recipient. Exp. Clin. Transplant. 9(1), 68–71 (2011).
  MedlineGoogle Scholar
• 59 Perfect JR, Dismukes WE, Dromer F et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the infectious diseases society of america. Clin. Infect. Dis. 50(3), 291–322 (2010).
  MedlineGoogle Scholar
• 60 Dismukes WE, Cloud G, Gallis HA et al. Treatment of cryptococcal meningitis with combination amphotericin B and flucytosine for four as compared with six weeks. N. Engl. J. Med. 317(6), 334–341 (1987).
  Medline CASGoogle Scholar
• 61 Sethi NK, Torgovnick J, Sethi PK. Cryptococcal meningitis after Imuran (azathioprine) therapy for autoimmune hepatitis. Eur. J. Gastroenterol. Hepatol. 19(10), 913–914 (2007).
  MedlineGoogle Scholar
• 62 Schmidt-Hieber M, Schwender J, Heinz WJ et al. Viral encephalitis after allogeneic stem cell transplantation: a rare complication with distinct characteristics of different causative agents. Haematologica 96(1), 142–149 (2011).
  MedlineGoogle Scholar
• 63 Patel VB, Theron G, Lenders L et al. Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. PLoS Med. 10(10), e1001536 (2013).•• Along with [62], reports on the utility of GeneXpert MTB/RIF assay in testing CSF for the diagnosis of TB meningitis. The studies reveal imperfect sensitivity with assay sensitivity highly dependent on the volume of CSF tested.
  MedlineGoogle Scholar
• 64 Nhu NT, Heemskerk D, Thu do DA et al. Evaluation of GeneXpert MTB/RIF for diagnosis of tuberculous meningitis. J. Clin. Microbiol. 52(1), 226–233 (2014).
  MedlineGoogle Scholar
• 65 Thwaites GE, Chau TT, Stepniewska K et al. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet 360(9342), 1287–1292 (2002).
  Medline CASGoogle Scholar
• 66 Amaya-Villar R, Garcia-Cabrera E, Sulleiro-Igual E et al. Three-year multicenter surveillance of community-acquired listeria monocytogenes meningitis in adults. BMC Infect. Dis. 10, 324 (2010).
  MedlineGoogle Scholar
• 67 Ray P, Badarou-Acossi G, Viallon A et al. Accuracy of the cerebrospinal fluid results to differentiate bacterial from non bacterial meningitis, in case of negative gram-stained smear. Am. J. Emerg. Med 25(2), 179–184 (2007).
  MedlineGoogle Scholar
• 68 Kambugu A, Meya DB, Rhein J et al. Outcomes of cryptococcal meningitis in Uganda before and after the availability of highly active antiretroviral therapy. Clin. Infect. Dis. 46(11), 1694–1701 (2008).
  Medline CASGoogle Scholar
• 69 Day JN, Chau TT, Lalloo DG. Combination antifungal therapy for cryptococcal meningitis. N. Engl. J. Med, 368(26), 2522–2523 (2013).
  Medline CASGoogle Scholar
• 70 Mohan S, Jain KK, Arabi M, Shah GV. Imaging of meningitis and ventriculitis. Neuroimaging Clin. N. Am. 22(4), 557–583 (2012).
  MedlineGoogle Scholar
• 71 Helbok R, Pongpakdee S, Yenjun S et al. Chronic meningitis in Thailand. Clinical characteristics, laboratory data and outcome in patients with specific reference to tuberculosis and cryptococcosis. Neuroepidemiology 26(1), 37–44 (2006).
  Medline CASGoogle Scholar
• 72 Hakim JG, Gangaidzo IT, Heyderman RS et al. Impact of HIV infection on meningitis in Harare, Zimbabwe: a prospective study of 406 predominantly adult patients. Aids 14(10), 1401–1407 (2000).
  Medline CASGoogle Scholar
• 73 Boulware DR, Bonham SC, Meya DB et al. Paucity of initial cerebrospinal fluid inflammation in cryptococcal meningitis is associated with subsequent immune reconstitution inflammatory syndrome. J. Infect. Dis. 202(6), 962–970 (2010).
  Medline CASGoogle Scholar
• 74 Altun O, Almuhayawi M, Ullberg M, Ozenci V. Clinical evaluation of the filmarray blood culture identification panel in identification of bacteria and yeasts from positive blood culture bottles. J. Clin. Microbiol. 51(12), 4130–4136 (2013).
  MedlineGoogle Scholar
• 75 Ruggiero P, McMillen T, Tang YW, Babady NE. Evaluation of the BioFire FilmArray respiratory panel and the GenMark eSensor respiratory viral panel on lower respiratory tract specimens. J. Clin. Microbiol. 52(1), 288–290 (2014).
  MedlineGoogle Scholar
• 76 Rath PM, Schoch B, Adamzik M, Steinmann E, Buer J, Steinmann J. Value of multiplex PCR using cerebrospinal fluid for the diagnosis of ventriculostomy-related meningitis in neurosurgery patients. Infection 42(4), 621–627 (2014).
  Medline CASGoogle Scholar
• 77 Biofire Diagnostics I. FilmArray Meningitis/Encephalitis Panel. http://filmarray.com/assets/pdf/MRKT-PRT-0297-02-FilmArray-Meningitis-Encephalitis-Panel-Info-Sheet.pdf.
  Google Scholar
• 78 Boulware DR, Rolfes MA, Rajasingham R et al. Multisite validation of cryptococcal antigen lateral flow assay and quantification by laser thermal contrast. Emerg. Infect. Dis. 20(1), 45–53 (2014).•• Reports the diagnostic performance of cryptococcal antigen lateral flow assay (CrAg LFA) in real world use, revealing that the CrAg LFA has the best diagnostic performance of any cryptococcal diagnostic test.
  MedlineGoogle Scholar
• 79 Kabanda T, Siedner MJ, Klausner JD, Muzoora C, Boulware DR. Point-of-care diagnosis and prognostication of cryptococcal meningitis with the cryptococcal antigen lateral flow assay on cerebrospinal fluid. Clin. Infect. Dis. 58(1), 113–116 (2014).
  Medline CASGoogle Scholar
• 80 Lindsley MD, Mekha N, Baggett HC et al. Evaluation of a newly developed lateral flow immunoassay for the diagnosis of cryptococcosis. Clin. Infect. Dis. 53(4), 321–325 (2011).
  MedlineGoogle Scholar
• 81 Jarvis JN, Percival A, Bauman S et al. Evaluation of a novel point-of-care cryptococcal antigen test on serum, plasma, and urine from patients with HIV-associated cryptococcal meningitis. Clin. Infect. Dis. 53(10), 1019–1023 (2011).
  Medline CASGoogle Scholar
• 82 Hansen J, Slechta ES, Gates-Hollingsworth MA et al. Large-scale evaluation of the immuno-mycologics lateral flow and enzyme-linked immunoassays for detection of cryptococcal antigen in serum and cerebrospinal fluid. Clin. Vaccine Immunol. 20(1), 52–55 (2013).
  Medline CASGoogle Scholar
• 83 Musubire AK, Boulware DR, Meya DB, Rhein J. Diagnosis and management of Cryptococcal relapse. J. AIDS Clin. Res. (Suppl. 3(3)), pii: S3–S003 (2013).
  MedlineGoogle Scholar
• 84 Brouwer AE, Teparrukkul P, Pinpraphaporn S et al. Baseline correlation and comparative kinetics of cerebrospinal fluid colony-forming unit counts and antigen titers in cryptococcal meningitis. J. Infect. Dis. 192(4), 681–684 (2005).
  MedlineGoogle Scholar
• 85 Chang CC, Lim A, Omarjee S et al. Cryptococcosis-IRIS is associated with lower Cryptococcus-specific IFN-gamma responses before antiretroviral therapy but not higher T-cell responses during therapy. J. Infect. Dis. 208(6), 898–906 (2013).
  Medline CASGoogle Scholar
• 86 Wheat LJ, Kohler RB, Tewari RP, Garten M, French ML. Significance of Histoplasma antigen in the cerebrospinal fluid of patients with meningitis. Arch. Intern. Med. 149(2), 302–304 (1989).
  Medline CASGoogle Scholar
• 87 Litvintseva AP, Lindsley MD, Gade L et al. Utility of (1–3)-beta-D-glucan testing for diagnostics and monitoring response to treatment during the multistate outbreak of fungal meningitis and other infections. Clin. Infect. Dis. 58(5), 622–630 (2014).
  Medline CASGoogle Scholar
• 88 Mikulska M, Furfaro E, Del Bono V et al. (1–3)-beta-D-glucan in cerebrospinal fluid is useful for the diagnosis of central nervous system fungal infections. Clin. Infect. Dis. 56(10), 1511–1512 (2013).
  MedlineGoogle Scholar
• 89 Marais S, Thwaites G, Schoeman JF et al. Tuberculous meningitis: a uniform case definition for use in clinical research. Lancet Infect. Dis. 10(11), 803–812 (2010).
  MedlineGoogle Scholar
• 90 Patel VB, Singh R, Connolly C et al. Comparison of a clinical prediction rule and a LAM antigen-detection assay for the rapid diagnosis of TBM in a high HIV prevalence setting. PLoS ONE 5(12), e15664 (2010).
  Medline CASGoogle Scholar
• 91 Ho J, Marais BJ, Gilbert GL, Ralph AP. Diagnosing tuberculous meningitis – have we made any progress? Trop. Med. Int. Health 18(6), 783–793 (2013).
  MedlineGoogle Scholar
• 92 Feng GD, Shi M, Ma L et al. Diagnostic Accuracy of intracellular mycobacterium tuberculosis detection for tuberculous meningitis. Am. J. Respir. Crit. Care Med. 189(4), 475–481 (2014).
  Medline CASGoogle Scholar
• 93 Huang Z, Xiong G, Luo Q et al. Evaluation of the performance of the microscopic observation drug susceptibility assay for diagnosis of extrapulmonary tuberculosis in China: a preliminary study. Respirology 19(1), 132–137 (2014).
  MedlineGoogle Scholar
• 94 Caws M, Dang TM, Torok E et al. Evaluation of the MODS culture technique for the diagnosis of tuberculous meningitis. PLoS ONE 2(11), e1173 (2007).
  MedlineGoogle Scholar
• 95 Xu HB, Jiang RH, Li L, Sha W, Xiao HP. Diagnostic value of adenosine deaminase in cerebrospinal fluid for tuberculous meningitis: a meta-analysis. Int. J. Tuberc. Lung Dis. 14(11), 1382–1387 (2010).
  MedlineGoogle Scholar
• 96 Park KH, Cho OH, Lee EM et al. T-cell-based assays on cerebrospinal fluid andPBMCs for rapid diagnosis of TB meningitis in non-HIV patients. Eur. Resp. J. 39(3), 768–770 (2012).
  Medline CASGoogle Scholar
• 97 Kim SH, Cho OH, Park SJ et al. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin. Infect. Dis. 50(10), 1349–1358 (2010).
  Medline CASGoogle Scholar
• 98 Patel VB, Singh R, Connolly C et al. Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population. Am. J. Respir. Crit. Care Med. 182(4), 569–577 (2010).
  Medline CASGoogle Scholar
• 99 Sardella IG, Singh M, Kumpfer S, Heringer RR, Saad MH, Sohler MP. Evaluation of Lionex TB kits and mycobacterial antigens for IgG and IgA detection in cerebrospinal fluid from tuberculosis meningitis patients. Mem. Inst. Oswaldo Cruz 105(5), 722–728 (2010).
  Medline CASGoogle Scholar
• 100 Pai M, Flores LL, Pai N, Hubbard A, Riley LW, Colford JM Jr. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect. Dis. 3(10), 633–643 (2003).
  Medline CASGoogle Scholar
• 101 Solomons RS, van Elsland SL, Visser DH et al. Commercial nucleic acid amplification tests in tuberculous meningitis-a meta-analysis. Diagn. Microbiol. Infect. Dis. 78(4), 398–403 (2014).
  Medline CASGoogle Scholar
• 102 Nagdev KJ, Kashyap RS, Parida MM et al. Loop-mediated isothermal amplification for rapid and reliable diagnosis of tuberculous meningitis. J. Clin. Microbiol. 49(5), 1861–1865 (2011).
  MedlineGoogle Scholar
• 103 Tortoli E, Russo C, Piersimoni C et al. Clinical validation of Xpert MTB/RIF for the diagnosis of extrapulmonary tuberculosis. Eur. Respir. J. 40(2), 442–447 (2012).
  MedlineGoogle Scholar
• 104 Causse M, Ruiz P, Gutierrez-Aroca JB, Casal M. Comparison of two molecular methods for rapid diagnosis of extrapulmonary tuberculosis. J. Clin. Microbiol. 49(8), 3065–3067 (2011).
  MedlineGoogle Scholar
• 105 Vadwai V, Boehme C, Nabeta P, Shetty A, Alland D, Rodrigues C. Xpert MTB/RIF: a new pillar in diagnosis of extrapulmonary tuberculosis? J. Clin. Microbiol. 49(7), 2540–2545 (2011).
  MedlineGoogle Scholar
• 106 Boulware DR. Utility of the Xpert MTB/RIF assay for diagnosis of tuberculous meningitis. PLoS Med. 10(10), e1001537 (2013).
  MedlineGoogle Scholar
• 107 Viallon A, Zeni F, Lambert C et al. High sensitivity and specificity of serum procalcitonin levels in adults with bacterial meningitis. Clin. Infect. Dis. 28(6), 1313–1316 (1999).
  Medline CASGoogle Scholar
• 108 Boisier P, Mahamane AE, Hamidou AA et al. Field evaluation of rapid diagnostic tests for meningococcal meningitis in Niger. Trop. Med. Int. Health 14(1), 111–117 (2009).
  Medline CASGoogle Scholar
• 109 Moisi JC, Saha SK, Falade AG et al. Enhanced diagnosis of pneumococcal meningitis with use of the Binax NOW immunochromatographic test of Streptococcus pneumoniae antigen: a multisite study. Clin. Infect. Dis. 48(Suppl. 2), S49–S56 (2009).
  Medline CASGoogle Scholar
• 110 Rose AM, Mueller JE, Gerstl S et al. Meningitis dipstick rapid test: evaluating diagnostic performance during an urban Neisseria meningitidis serogroup A outbreak, Burkina Faso, 2007. PLoS ONE 5(6), e11086 (2010).
  MedlineGoogle Scholar
• 111 Sakushima K, Hayashino Y, Kawaguchi T, Jackson JL, Fukuhara S. Diagnostic accuracy of cerebrospinal fluid lactate for differentiating bacterial meningitis from aseptic meningitis: a meta-analysis. J. Infect. 62(4), 255–262 (2011).
  MedlineGoogle Scholar
• 112 Srinivasan L, Pisapia JM, Shah SS, Halpern CH, Harris MC. Can broad-range 16S ribosomal ribonucleic acid gene polymerase chain reactions improve the diagnosis of bacterial meningitis? A systematic review and meta-analysis. Ann. Emerg. Med. 60(5), 609–620 e602 (2012).
  MedlineGoogle Scholar
• 113 Kim DW, Kilgore PE, Kim EJ, Kim SA, Anh DD, Seki M. Loop-mediated isothermal amplification assay for detection of Haemophilus influenzae type b in cerebrospinal fluid. J. Clin. Microbiol. 49(10), 3621–3626 (2011).
  Medline CASGoogle Scholar
• 114 Kim DW, Kilgore PE, Kim EJ et al. The enhanced pneumococcal LAMP assay: a clinical tool for the diagnosis of meningitis due to Streptococcus pneumoniae. PLoS ONE 7(8), e42954 (2012).
  Medline CASGoogle Scholar
• 115 Meyler KL, Meehan M, Bennett D, Cunney R, Cafferkey M. Development of a diagnostic real-time polymerase chain reaction assay for the detection of invasive Haemophilus influenzae in clinical samples. Diagn. Microbiol. Infect. Dis. 74(4), 356–362 (2012).
  Medline CASGoogle Scholar
• 116 Le Monnier A, Abachin E, Beretti JL, Berche P, Kayal S. Diagnosis of Listeria monocytogenes meningoencephalitis by real-time PCR for the hly gene. J. Clin. Microbiol. 49(11), 3917–3923 (2011).
  Medline CASGoogle Scholar
• 117 Volle R, Nourrisson C, Mirand A et al. Quantitative real-time RT-PCR assay for research studies on enterovirus infections in the central nervous system. J. Virol. Meth. 185(1), 142–148 (2012).
  Medline CASGoogle Scholar
• 118 Ninove L, Nougairede A, Gazin C et al. Comparative detection of enterovirus RNA in cerebrospinal fluid: GeneXpert system vs. real-time RT-PCR assay. Clin. Microbiol. Infect. 17(12), 1890–1894 (2011).
  Medline CASGoogle Scholar
• 119 Zarrouk V, Leflon-Guibout V, Robineaux S et al. Broad-range 16S rRNA PCR with cerebrospinal fluid may be unreliable for management of postoperative aseptic meningitis. J. Clin. Microbiol. 48(9), 3331–3333 (2010).
  MedlineGoogle Scholar