Research Article

Association between CYP19A1 rs6493497 and rs936306 polymorphisms and depression susceptibility in the Chinese population

https://orcid.org/0000-0002-2259-348X

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

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Yuan Yan

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

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Huacheng Yan

Department of Infectious Disease Prevention & Control, Center for Disease Control & Prevention of Southern Theatre Command, Guangzhou, 510507, China

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Guibo Xie

Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

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Lei Shi

Department of Pharmacy, General Hospital of Southern Theatre Command, Guangzhou, 510010, China

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Yuguan Wen

Department of Pharmacy, Guangzhou Brain Hospital, Guangzhou, 510370, China

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Qingxian Chang

*Author for correspondence:

E-mail Address: chqx0210@hotmail.com

Department of Gynecology & Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China

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Published Online:11 Jan 2023https://doi.org/10.2217/bmm-2022-0370

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Abstract

Aim: The CYP19A1 gene encodes the key aromatase for estrogen biosynthesis, and this study aimed to explore the relationship between CYP19A1 rs6493497 and rs936306 polymorphisms and depression risk. Methods:CYP19A1 rs6493497 and rs936306 genotyping was performed on 502 depression patients and 504 healthy controls. Results: In the general population, no significant association was observed between the CYP19A1 rs6493497 variant and depression, whereas that CYP19A1 rs936306 variant significantly reduced depression risk in the recessive model. In subgroup analysis, a significant association of the CYP19A1 rs6493497 variant with reduced depression risk was found in males aged 46–65 in the genotype, dominant and additive models. Conclusion: The CYP19A1 rs936306 variant may reduce depression risk, and the rs6493497 variant is associated with decreased depression risk in males aged 46–65.

Plain language summary

The cause of depression is complex and not fully elucidated; the research evidence suggests that changes in estrogen levels may partly account for the risk of the onset of depression. The CYP19A1 gene encodes the key enzyme for estrogen biosynthesis, and this study aimed to explore whether the two loci (rs6493497 and rs936306) variants of the CYP19A1 gene are associated with the risk of occurrence of depression. Five hundred two patients with depression and 504 healthy controls were enrolled. The results of this study indicate that the CYP19A1 gene rs936306 variant may reduce the risk of occurrence of depression, and the rs6493497 variant is associated with decreased depression risk in men aged 46–65.

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Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 16, No. 16

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History

Received 29 May 2022

Accepted 14 December 2022

Published online 11 January 2023

Published in print November 2022

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Keywords

Author contributions

Q Peng: investigation, writing – review and editing; Q Chang: conceptualization, writing – original draft, data curation; Y Yan: methodology, validation; H Yan: conceptualization, writing – review and editing, funding acquisition; G Xie: formal analysis, supervision; L Shi: resources; Y Wen: resources.

Financial & competing interests disclosure

This study was supported by grants from the Medical Scientific Research Foundation of Guangdong Province (A2015571) and the Science and Technology Planning Project of Guangdong Province (2017A020212002). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

The authors state that they have obtained appropriate institutional review board approval from the Ethics Committee of the General Hospital of the Southern Theatre Command. Informed consent has been obtained from the participants involved.

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