Meta-Analysis

Prognostic and clinicopathological role of long noncoding RNA NORAD in various cancers: a meta-analysis

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Qianqian Zhang

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Jian Wang

https://orcid.org/0000-0001-5066-1526

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Wei Feng

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Yuqian Chen

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Jin Liu

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Zhan Qu

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Manxiang Li

*Author for correspondence: Tel.: +86 029 8532 4053;

E-mail Address: manxiangli@hotmail.com

Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710061, China

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Published Online:12 Mar 2021https://doi.org/10.2217/bmm-2020-0566

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Abstract

Aim: Long noncoding RNA (lncRNA) noncoding RNA activated by DNA damage (NORAD) is widely investigated in different tumors. Our meta-analysis intends to assess the prognostic and clinicopathological value of NORAD in cancers. Materials & methods: We searched PubMed, Web of Science, Embase and Chinese National Knowledge Infrastructure from inception to 1 August 2020. Results: The results showed that higher expression of NORAD had a significant association with worse overall survival. Additionally, correlations were detected between elevated level of NORAD and poor differentiation degree, positive lymph node metastasis and large tumor size in cancer patients. Conclusion: LncRNA NORAD can serve as a novel and promising biomarker for prognosis and clinicopathological characteristics in different cancers.

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Vol. 15, No. 6

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History

Received 2 September 2020

Accepted 2 February 2021

Published online 12 March 2021

Published in print April 2021

Information

Keywords

Author contributions

Q Wang, Q Zhang and M Li designed the project. J Wang, W Feng and Y Chen performed data extraction and analysis. J Liu and Z Qu performed the quality assessment. Q Wang and Q Zhang contributed to the article drafting. Q Wang and M Li revised the manuscript critically. All authors read and approved the final manuscript.

Acknowledgments

The authors thank all researchers for their contributions.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (grant number: 81970050). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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