Research Article

Prevalence and determinants of elevated D-dimer in patients with hypertrophic cardiomyopathy

*Author for correspondence:

Department of Cardiology and Macrovascular Disease, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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Changlin Zhang

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Jiansong Yuan

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Jingang Cui

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Shubin Qiao

**Author for correspondence:

E-mail Address: qsbfw@sina.com

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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Published Online:14 Feb 2020https://doi.org/10.2217/bmm-2019-0225

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Abstract

Aim: To evaluate D-dimer levels in patients with hypertrophic cardiomyopathy (HCM). Patients & methods: A total of 346 patients with HCM were recruited. Plasma D-dimer was determined by clinical laboratory of our hospital. Left ventricular mass, stroke volume, cardiac output and cardiac index were assessed with cardiovascular magnetic resonance. Results: A total of 36 (10.4%) patients had elevated D-dimer levels. Age, female patients and statin therapy were independently associated with increasing D-dimer levels, and predictors of elevated D-dimer. Conclusion: Patients with HCM may have higher plasma D-dimer levels than subjects without HCM. D-dimer levels in patients with HCM are influenced by age, sex, atrial fibrillation, statin therapy and diastolic blood pressure.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 14, No. 2

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History

Received 24 May 2019

Accepted 22 November 2019

Published online 14 February 2020

Published in print February 2020

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Keywords

Author contributions

C Yang and S Qiao conceived and designed the study. C Zhang, J Yuan, J Cui and C Yang collected data. C Zhang, S Qiao and J Yuan analyzed the data. C Yang wrote the paper.

Financial & competing interests disclosure

This work was supported by the National Natural Science Foundation of China (grant number 81370327) and Training Program of Natural Science Foundation of Capital Medical University (grant number PYZ2018100). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Authors state that they have obtained appropriate institutional review board approval or have followed the principles outlined in the Declaration of Helsinki for all human investigations. Informed consent has been obtained from the participants involved.

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