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Leptin and adiponectin levels in obstructive sleep apnea phenotypes

    Zuleyha Bingol

    Department of Pulmonary Medicine, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    ,
    Ekrem Bilal Karaayvaz

    Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    ,
    Aysegul Telci

    Department of Biochemistry, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    ,
    Ahmet Kaya Bilge

    Department of Cardiology, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    ,
    Gulfer Okumus

    Department of Pulmonary Medicine, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    &
    Esen Kiyan

    *Author for correspondence: Tel.: +90 212 414 20 00; Fax: +90 212 635 27 08;

    E-mail Address: kiyanesen@gmail.com

    Department of Pulmonary Medicine, Faculty of Medicine, Istanbul University, Istanbul, 34093, Turkey

    Published Online:https://doi.org/10.2217/bmm-2018-0293

    Objective: To examine the serum levels of leptin and adiponectin in different obstructive sleep apnea (OSA) phenotypes. Methods: Obese patients who were admitted to our sleep laboratory were included. All patients underwent spirometry, daytime arterial blood gas analysis, polysomnography and transthoracic echocardiography. Serum levels of adiponectin and leptin were recorded. Results: Analysis included 146 OSA patients (81 females, 65 males, age: 49.8 ± 10.7 years, body mass index: 40.3 ± 4.9 kg/m2, 47.9% severe OSA, 42.5% severe obesity). Females had higher leptin and adiponectin levels (p < 0.001; p < 0.001, respectively). Leptin levels were higher in patients with severe obesity (p < 0.001). Severe OSA patients had lower leptin and adiponectin levels (p = 0.023; p = 0.035, respectively). Conclusion: Adipokine levels were different especially in OSA patients with severe obesity, female gender and severe OSA.

    Papers of special note have been highlighted: • of interest

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