Plasma and cerebrospinal fluid levels of cytokines as disease markers of neurologic manifestation in long-term HTLV-1 infected individuals

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References

• 1 Willems L, Hasegawa H, Accolla R et al. Reducing the global burden of HTLV-1 infection: an agenda for research and action. Antiviral Res. 137, 41–48 (2017). • The HTLV task force strengthen medical research and public health response to viral agents of human disease and prepare for new pandemic threats.
  Medline CASGoogle Scholar
• 2 Osame M, Usuku K, Izumo S et al. HTLV-I associated myelopathy, a new clinical entity. Lancet 1(8488), 1031–1032 (1986).
  Medline CASGoogle Scholar
• 3 Souza A, Santos S, Carvalho LP, Grassi MFR, Carvalho EM. Impairment of the humoral and CD4(⁺) T cell responses in HTLV-1-infected individuals immunized with tetanus toxoid. Hum. Immunol. 77(8), 674–81 (2016).
  Medline CASGoogle Scholar
• 4 Goncalves DU, Proietti FA, Barbosa-Stancioli EF et al. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) inflammatory network. Inflam. Allergy Drug Targets 7(2), 98–107 (2008).
  Medline CASGoogle Scholar
• 5 Matsuura E, Yamano Y, Jacobson S. Neuroimmunity of HTLV-I infection. J. Neuroimmune Pharmacol. 5(3), 310–25 (2010). •• An important review paper about pathophysiological findings on HTLV-associated myelopathy/tropical spastic paraparesis and focus on viral-host immune responses to the virus in HTLV-I infected individuals.
  MedlineGoogle Scholar
• 6 Jacobson S. Immunopathogenesis of human T cell lymphotropic virus type I-associated neurologic disease. J. Infect. Dis. 186(Suppl.), S187–S192 (2002).
  MedlineGoogle Scholar
• 7 Andrade RG, Ribeiro MA, Namen-Lopes MSS et al. Evaluation of the use of real-time PCR for human T cell lymphotropic virus 1 and 2 as a confirmatory test in screening for blood donors. Rev. Soc. Bras. Med. Trop. 43(2), 111–115 (2010).
  MedlineGoogle Scholar
• 8 Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33(11), 1444–1452 (1983). •• Explanation of a new Expanded Disability Status Scale with each of the former steps divided into two.
  Medline CASGoogle Scholar
• 9 Furtado M dos SBS, Andrade RG, Romanelli LCF et al. Monitoring the HTLV-1 proviral load in the peripheral blood of asymptomatic carriers and patients with HTLV-associated myelopathy/tropical spastic paraparesis from a Brazilian cohort: ROC curve analysis to establish the threshold for risk disease. J. Med. Virol. 84(4), 664–671 (2012).
  MedlineGoogle Scholar
• 10 Grassi MFR, Olavarria VN, Kruschewsky R de A et al. Human T cell lymphotropic virus type 1 (HTLV-1) proviral load of HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients according to new diagnostic criteria of HAM/TSP. J. Med. Virol. 83(7), 1269–74 (2011).
  Medline CASGoogle Scholar
• 11 Vallinoto ACR, Santana BB, Sá KSG et al. HTLV-1-Associated myelopathy/tropical spastic paraparesis is not associated with SNP rs12979860 of the IL-28B gene. Med. Inflamm. 2015, 804167 (2015).
  MedlineGoogle Scholar
• 12 Araya N, Sato T, Yagishita N et al. Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease. Viruses 3(9), 1532–1548 (2011).
  Medline CASGoogle Scholar
• 13 Montanheiro PA, Penalva de Oliveira AC, Smid J et al. The elevated interferon gamma production is an important immunological marker in HAM/TSP pathogenesis. Scand. J. Immunol. 70(4), 403–407 (2009).
  Medline CASGoogle Scholar
• 14 Sagawa K, Mochizuki M, Masuoka K et al. Immunopathological mechanisms of human T cell lymphotropic virus type 1 (HTLV-I) uveitis. Detection of HTLV-I-infected T cells in the eye and their constitutive cytokine production. J. Clin. Invest. 95(2), 852–858 (1995).
  Medline CASGoogle Scholar
• 15 de Castro-Costa CM, Araújo A de QC, Câmara CC et al. Pain in tropical spastic paraparesis/HTLV-I associated myelopathy patients. Arquivos de neuro-psiquiatria 67(3B), 866–870 (2009).
  MedlineGoogle Scholar
• 16 Ribas JGR, Melo GCN. [Human T-cell lymphotropic virus type 1(HTLV-1)-associated myelopathy]. Rev. Soc. Bras. Med. Trop. 35(4), 377–384 (2002).
  MedlineGoogle Scholar
• 17 Nagasaka M, Morioka I, Kawabata A et al. Comprehensive analysis of serum cytokines/chemokines in febrile children with primary human herpes virus-6B infection. J. Infect. Chemother. 22(9), 593–598 (2016).
  Medline CASGoogle Scholar
• 18 Zeremski M, Petrovic LM, Chiriboga L et al. Intrahepatic levels of CXCR3-associated chemokines correlate with liver inflammation and fibrosis in chronic hepatitis C. Hepatology 48(5), 1440–1450 (2008).
  Medline CASGoogle Scholar
• 19 Müller M, Carter S, Hofer MJ, Campbell IL. Review: the chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity – a tale of conflict and conundrum. Neuropathol. Appl. Neurobiol. 36(5), 368–387 (2010).
  MedlineGoogle Scholar
• 20 Rupprecht TA, Koedel U, Muhlberger B, Wilske B, Fontana A, Pfister H-W. CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis. J. Neurol. 252(7), 820–823 (2005).
  Medline CASGoogle Scholar
• 21 Moniuszko A, Czupryna P, Pancewicz S et al. Evaluation of CXCL8, CXCL10, CXCL11, CXCL12 and CXCL13 in serum and cerebrospinal fluid of patients with neuroborreliosis. Immunol. Lett. 157(1–2), 45–50 (2014). • Knowledge of the role of chemokines in inflammation during neuroborreliosis in serum and cerebrospinal fluid.
  Medline CASGoogle Scholar
• 22 Araya N, Sato T, Ando H et al. HTLV-1 induces a Th1-like state in CD4⁺CCR4⁺ T cells. J. Clin. Invest. 124(8), 3431–3442 (2014).
  Medline CASGoogle Scholar
• 23 Guerreiro JB, Santos SB, Morgan DJ et al. Levels of serum chemokines discriminate clinical myelopathy associated with human T lymphotropic virus type 1 (HTLV-1)/tropical spastic paraparesis (HAM/TSP) disease from HTLV-1 carrier state. Clin. Exp. Immunol. 145(2), 296–301 (2006).
  Medline CASGoogle Scholar
• 24 Sato T, Coler-Reilly A, Utsunomiya A et al. CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis. PLoS Negl. Trop. Dis. 7(10), e2479 (2013).
  MedlineGoogle Scholar
• 25 Nagai M, Kubota R, Greten TF, Schneck JP, Leist TP, Jacobson S. Increased activated human T cell lymphotropic virus type I (HTLV-I) Tax11–19-specific memory and effector CD8⁺ cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with HTLV-I provirus load. J. Infect. Dis. 183(2), 197–205 (2001).
  Medline CASGoogle Scholar
• 26 Best I, López G, Verdonck K et al. IFN-gamma production in response to Tax 161–233, and frequency of CD4⁺ Foxp3⁺ and Lin HLA-DRhigh CD123⁺ cells, discriminate HAM/TSP patients from asymptomatic HTLV-1-carriers in a Peruvian population. Immunology 128(1 Suppl.), e777–e786 (2009).
  MedlineGoogle Scholar
• 27 Kuroda Y, Matsui M. Cerebrospinal fluid interferon-gamma is increased in HTLV-I-associated myelopathy. J. Neuroimmunol. 42(2), 223–226 (1993).
  Medline CASGoogle Scholar
• 28 Nishimoto N, Yoshizaki K, Eiraku N et al. Elevated levels of interleukin-6 in serum and cerebrospinal fluid of HTLV-I-associated myelopathy/tropical spastic paraparesis. J. Neurol. Sci. 97(2–3), 183–193 (1990).
  Medline CASGoogle Scholar
• 29 Ohbo K, Sugamura K, Sekizawa T, Kogure K. Interleukin-6 in cerebrospinal fluid of HTLV-I-associated myelopathy. Neurology 41(4), 594–595 (1991).
  Medline CASGoogle Scholar
• 30 Schultz RM, Kleinschmidt WJ. Functional identity between murine gamma interferon and macrophage activating factor. Nature 305(5931), 239–240 (1983).
  Medline CASGoogle Scholar
• 31 Raine CS, Cannella B, Duijvestijn AM, Cross AH. Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Laboratory investigation; a journal of technical methods and pathology. Lab. Invest. 63(4), 476–489 (1990).
  Medline CASGoogle Scholar
• 32 Umehara F, Izumo S, Ronquillo AT, Matsumuro K, Sato E, Osame M. Cytokine expression in the spinal cord lesions in HTLV-I-associated myelopathy. J. Neuropathol. Exp. Neurol. 53(1), 72–77 (1994).
  Medline CASGoogle Scholar
• 33 Ottum PA, Arellano G, Reyes LI, Iruretagoyena M, Naves R. Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation. Front. Immunol. 6, 539 (2015).
  MedlineGoogle Scholar
• 34 Salmaggi A, Gelati M, Dufour A et al. Expression and modulation of IFN-gamma-inducible chemokines (IP-10, Mig, and I-TAC) in human brain endothelium and astrocytes: possible relevance for the immune invasion of the central nervous system and the pathogenesis of multiple sclerosis. J. Interferon Cytokine Res. 22(6), 631–640 (2002).
  Medline CASGoogle Scholar