Research Article

Association between haptoglobin gene and insulin resistance in Arab–Americans

Kyle J Burghardt

*Author for correspondence:

E-mail Address: kburg@wayne.edu

Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA

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Dana El Masri

Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA

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Sabrina E Dass

Department of Chemistry, Kalamazoo College, Kalamazoo, MI 49006, USA

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Sara S Shikwana

Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA

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Linda A Jaber

Eugene Applebaum College of Pharmacy & Health Sciences, Wayne State University, Detroit, MI 48201, USA

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Published Online:17 Oct 2017https://doi.org/10.2217/bmm-2017-0094

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Abstract

Aim: To analyze associations between variation in the HP gene and lipid and glucose-related measures in Arab–Americans. Secondary analyses were performed based on sex. Patients & methods: Genomic DNA was extracted from samples obtained from a previous epidemiological study of diabetes in Arab–Americans. The HP 1 and 2 alleles were analyzed by polymerase chain reaction and gel electrophoresis. Associations were analyzed by linear regression. Results & conclusion: Associations were identified between the heterozygous haptoglobin 2–1 genotype and insulin resistance, fasting insulin and fasting c-peptide. The effect of sex did not remain significant after adjustment for relevant variables. HP genetic variation may have utility as a biomarker of insulin resistance and diabetes risk in Arab–Americans, however, future prospective studies are needed.

Keywords:

Papers of special note have been highlighted as: • of interest; •• of considerable interest

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Vol. 11, No. 11

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History

Received 17 March 2017

Accepted 11 July 2017

Published online 17 October 2017

Published in print November 2017

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Ethical conduct of research

The study was approved by the Wayne State University Institutional Review Board.

Acknowledgements

The authors acknowledge E Conger for her contribution in the study.

Financial & competing interests disclosure

This samples utilized in this work were funded by an American Diabetes Grant (Jaber PI). Theauthors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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