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Management of balance and gait in older individuals with Parkinson’s disease

    Ryan P Duncan

    Washington University School of Medicine, Program in Physical Therapy, Campus Box 8502, 4444 Forest Park Blvd, St Louis, MO 63108, USA

    ,
    Abigail L Leddy

    Washington University School of Medicine, Program in Physical Therapy, Campus Box 8502, 4444 Forest Park Blvd, St Louis, MO 63108, USA

    &
    Gammon M Earhart

    † Author for correspondence

    Department of Anatomy & Neurobiology, Washington University School of Medicine, St Louis, MO, USA.

    Published Online:https://doi.org/10.2217/ahe.10.79

    Difficulties with walking and balance are common among people with Parkinson’s disease (PD). Effective management of these walking and balance problems is critical, as these issues can contribute to decreased mobility, falls, social isolation, reduced quality of life and increased mortality. This article provides an overview of the gait and balance disorders associated with PD and discusses the methods currently utilized to manage gait and balance problems among people with PD. These methods include pharmacological, surgical and rehabilitative approaches. Remaining challenges and future directions, including the need for comprehensive, multidisciplinary, patient-centered care provided by qualified movement disorders experts, are also highlighted.

    Papers of special note have been highlighted as: • of interest •• of considerable interest

    Bibliography

    • Fahn S: Description of Parkinson’s disease as a clinical syndrome. Ann. NY Acad. Sci.991,1–14 (2003).•• Very informative and easy to understand overview of the major signs and symptoms of Parkinson’s disease (PD).Crossref, Medline, CASGoogle Scholar
    • Chade AR, Kasten M, Tanner CM: Nongenetic causes of Parkinson’s disease. J. Neural Transm.70,147–151 (2006).CASGoogle Scholar
    • Biskup S, Gerlach M, Kupsch A et al.: Genes associated with Parkinson syndrome. J. Neurol.255,8–17 (2008).Crossref, Medline, CASGoogle Scholar
    • Taylor KS, Cook JA, Counsell CE: Heterogeneity in male to female risk for Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry78,905–906 (2007).Crossref, Medline, CASGoogle Scholar
    • Spillman BC, Lubitz J: New estimates of lifetime nursing home use: have patterns of use changed? Med. Care40,965–975 (2002).Crossref, MedlineGoogle Scholar
    • Perry EK, McKeith I, Thompson P et al.: Topography, extent, and clinical relevance of neurochemical deficits in dementia of Lewy body type, Parkinson’s disease, and Alzheimer’s disease. Ann. NY Acad. Sci.640,197–202 (1991).Crossref, Medline, CASGoogle Scholar
    • Bloem BR, Hausdorff JM, Visser JE et al.: Falls and freezing of gait in Parkinson’s disease: a review of two interconnected, episodic phenomena. Mov. Disord.19(8),871–884 (2004).•• Includes excellent model of how gait and balance impairments are part of a vicious cycle that includes falling and reduced quality of life.Crossref, MedlineGoogle Scholar
    • Morris ME, Iansek R, Matyas TA et al.: Ability to modulate walking cadence remains intact in Parkinson’s disease. J. Neurol. Neurosurg. Psych.57(12),1532–1534 (1994).Crossref, Medline, CASGoogle Scholar
    • Morris ME, Iansek R, Matyas TA et al.: The pathogenesis of gait hypokinesia in Parkinson’s disease. Brain117(Pt 5),1169–1181 (1994).Crossref, MedlineGoogle Scholar
    • 10  Morris ME, Iansek R, Matyas TA et al.: Stride length regulation in Parkinson’s disease: normalization strategies and underlying mechanisms. Brain119,551–568 (1996).Crossref, MedlineGoogle Scholar
    • 11  Morris ME, McGinley J, Huxham F et al.: Constraints on the kinetic, kinematic, and spatiotemporal parameters of gait in Parkinson’s disease. Hum. Mov. Sci.18,461–483 (1999).CrossrefGoogle Scholar
    • 12  Morris ME, Huxham FE, McGinley J et al.: Gait disorders and gait rehabilitation in Parkinson’s disease. Adv. Neurol.87,347–361 (2001).Medline, CASGoogle Scholar
    • 13  Pedersen SW, Öberg B, Larsson LE et al.: Gait analysis, isokinetic muscle strength measurement in patients with Parkinson’s disease. Scand. J. Rehab. Med.29,67–74 (1997).Medline, CASGoogle Scholar
    • 14  Rogers MW: Disorders of posture, balance, and gait in Parkinson’s disease. Clin. Geriatr. Med.12,825–845 (1996).Crossref, Medline, CASGoogle Scholar
    • 15  Lewis GN, Byblow WD, Walt SE: Stride length regulation in Parkinson’s disease: the use of extrinsic, visual cues. Brain123(Pt 10),2077–2090 (2000).Crossref, MedlineGoogle Scholar
    • 16  Grasso R, Peppe A, Stratta F et al.: Basal ganglia and gait control: apomorphine administration and internal pallidum stimulation in Parkinson’s disease. Exp. Brain Res.126(2),139–148, (1999).Crossref, Medline, CASGoogle Scholar
    • 17  Steiger MJ, Thompson PD, Marsden CD: Disordered axial movement in Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry61(6),645–648 (1996).Crossref, Medline, CASGoogle Scholar
    • 18  Camicioli R, Oken BS, Sexton G et al.: Verbal fluency task affects gait in Parkinson’s disease with motor freezing. J. Geriatr. Psychiatry Neurol.11(4),181–185 (1998).Crossref, Medline, CASGoogle Scholar
    • 19  O’Shea S, Morris ME, Iansek R: Dual task interference during gait in people with Parkinson’s disease: effects of motor versus cognitive secondary tasks. Phys. Ther.82(9),888–897 (2002).Crossref, MedlineGoogle Scholar
    • 20  Rochester L, Hetherington V, Jones D et al.: Attending to the task: interference effects of functional tasks on walking in Parkinson’s disease and the roles of cognition, depression, fatigue, and balance. Arch. Phys. Med. Rehabil.85(10),1578–1585 (2004).Crossref, MedlineGoogle Scholar
    • 21  Rochester L, Hetherington V, Jones D et al.: The effect of external rhythmic cues (auditory and visual) on walking during a functional task in homes of people with Parkinson’s disease. Arch. Phys. Med. Rehabil.86(5),999–1006 (2005).Crossref, MedlineGoogle Scholar
    • 22  Rochester L, Nieuwboer A, Baker K et al.: The attentional cost of external rhythmical cues and their impact on gait in Parkinson’s disease: effect of cue modality and task complexity. J. Neural Transm.114(10),1243–1248 (2007).Crossref, Medline, CASGoogle Scholar
    • 23  Plotnik M, Giladi N, Hausdorff JM: Bilateral coordination of gait and Parkinson’s disease: the effects of dual tasking. J. Neurol. Neurosurg. Psychiatry80(3),347–50 (2009).Crossref, Medline, CASGoogle Scholar
    • 24  Hackney M, Earhart GM: Backward walking in Parkinson disease. Mov. Disord.24(2),218–223 (2009).Crossref, MedlineGoogle Scholar
    • 25  Hackney ME, Earhart GM: The effects of a secondary task on forward and backward walking in Parkinson disease. Neurorehabil. Neural Repair (2011) (In press).Google Scholar
    • 26  Morris ME, Huxham F, McGinley J et al.: The biomechanics and motor control of gait in Parkinson disease. Clin. Biomech.16(6),459–470 (2001).• Good description of gait in PD and effects of medication.Crossref, Medline, CASGoogle Scholar
    • 27  Stack EL, Ashburn AM, Jupp KE: Strategies used by people with Parkinson’s disease who report difficulty turning. Parkinsonism Relat. Disord.12,87–92 (2006).Crossref, MedlineGoogle Scholar
    • 28  Crenna P, Carpinella I, Rabuffetti M et al.: The association between impaired turning and normal straight walking in Parkinson’s disease. Gait Posture26,172–178 (2006).CrossrefGoogle Scholar
    • 29  Visser JE, Voermans NC, Oude Nijhuis LB et al.: Quantification of trunk rotations during turning and walking in Parkinson’s disease. Clin. Neurophysiol.118,1602–1606 (2007).Crossref, MedlineGoogle Scholar
    • 30  Hong M, Perlmutter JS, Earhart GM: A kinematic and electromyographic analysis of turning in people with Parkinson disease. Neurorehabil. Neural Repair23(2),166–176 (2009).Crossref, MedlineGoogle Scholar
    • 31  Nieuwboer A, Dom R, De Weerdt W et al.: Abnormalitites of the spatiotemporal characteristics of gait at the onset of freezing in Parkinson’s disease. Mov. Disord.16,1066–1075 (2001).Crossref, Medline, CASGoogle Scholar
    • 32  Giladi N, Nieuwboer A: Understanding and treating freezing of gait in parkinsonism, proposed working definition, and setting the stage. Mov. Disord.23,S423–S425 (2008).Crossref, MedlineGoogle Scholar
    • 33  Michałowska M, Fiszer U, Krygowska-Wajs A et al.: Falls in Parkinson’s disease. Causes and impact on patients’ quality of life. Funct. Neurol.20(4),163–168 (2005).MedlineGoogle Scholar
    • 34  Robinson K, Dennison A, Roalf D et al.: Falling risk factors in Parkinson’s disease. NeuroRehabilitation20(3),169–182 (2005).Crossref, MedlineGoogle Scholar
    • 35  Moore ST, MacDougall HG, Ondo WG: Ambulatory monitoring of freezing of gait in Parkinson’s disease. J. Neurosci. Methods167,340–348 (2008).Crossref, MedlineGoogle Scholar
    • 36  Cumming R, Klineberg R: Fall frequency and characteristics and the risk of hip fractures. J. Am. Ger. Soc.42,774–778 (1994).Crossref, Medline, CASGoogle Scholar
    • 37  Benatru I, Vaugoyeau M, Azulay JP: Postural disorders in Parkinson’s disease. Neurophysiologie Clinique38(6),459–465 (2008).Crossref, Medline, CASGoogle Scholar
    • 38  Chastan N, Debono B, Maltete D, Weber J: Discordance between measured postural instability and absence of clinical symptoms in Parkinson’s disease patients in the early stages of the disease. Mov. Disord.23(3),366–372 (2008).Crossref, MedlineGoogle Scholar
    • 39  Frenklach A, Louie S, Koop MM, Bronte-Stewart H: Excessive postural sway and the risk of falls at different stages of Parkinson’s disease. Mov. Disord.24(3),377–385 (2009).Crossref, MedlineGoogle Scholar
    • 40  Mancini M, Zampieri C, Carlson-Kuhta P, Chiari L, Horak FB: Anticipatory postural adjustments prior to step initiation are hypometric in untreated Parkinson’s disease: an accelerometer-based approach. Eur. J. Neurol.16(9),1028–1034 (2009).Crossref, Medline, CASGoogle Scholar
    • 41  Grimbergen YA, Langston JW, Roos RA, Bloem BR: Postural instability in Parkinson’s disease: the adrenergic hypothesis and the locus coeruleus. Expert Rev. Neurother.9(2),279–290 (2009).Crossref, Medline, CASGoogle Scholar
    • 42  Horak FB, Dimitrova D, Nutt JG: Direction-specific postural instability in subjects with Parkinson’s disease. Exp. Neurol.193(2),504–521 (2005).Crossref, MedlineGoogle Scholar
    • 43  Kerr GK, Worringham CJ, Cole MH, Lacherez PF, Wood JM, Silburn PA: Predictors of future falls in Parkinson disease. Neurology75(2),116–124 (2010).Crossref, Medline, CASGoogle Scholar
    • 44  Kim S, Horak FB, Carlson-Kuhta P, Park S: Postural feedback scaling deficits in Parkinson’s disease. J. Neurophysiol.102(5),2910–2920 (2009).Crossref, MedlineGoogle Scholar
    • 45  King LA, St George RJ, Carlson-Kuhta P, Nutt JG, Horak FB: Preparation for Compensatory Forward Stepping in Parkinson’s Disease. Arch. Phys. Med. Rehabil.91(9),1332–1338 (2010).Crossref, MedlineGoogle Scholar
    • 46  McVey MA, Stylianou AP, Luchies CW et al.: Early biomechanical markers of postural instability in Parkinson’s disease. Gait Posture30(4),538–542 (2009).Crossref, MedlineGoogle Scholar
    • 47  Grimbergen YA, Munneke M, Bloem BR: Falls in Parkinson’s disease. Curr. Opin. Neurol.17(4),405–415 (2004).Crossref, MedlineGoogle Scholar
    • 48  Bohnen NI, Cham R: Postural control, gait, and dopamine functions in parkinsonian movement disorders. Clin. Geriatr. Med.22(4),797–812, vi (2006).Crossref, MedlineGoogle Scholar
    • 49  Visser M, Marinus J, Bloem BR, Kisjes H, van den Berg BM, van Hilten JJ: Clinical tests for the evaluation of postural instability in patients with Parkinson’s disease. Arch. Phys. Med. Rehabil.84(11),1669–1674 (2003).Crossref, MedlineGoogle Scholar
    • 50  Valkovic P, Brozova H, Botzel K, Ruzicka E, Benetin J: Push-and-release test predicts Parkinson fallers and nonfallers better than the pull test: comparison in OFF and ON medication states. Mov. Disord.23(10),1453–1457 (2008).Crossref, MedlineGoogle Scholar
    • 51  Blaszczyk JW, Orawiec R, Duda-Klodowska D, Opala G: Assessment of postural instability in patients with Parkinson’s disease. Exp. Brain Res.183(1),107–114 (2007).Crossref, Medline, CASGoogle Scholar
    • 52  Buckley TA, Pitsikoulis C, Hass CJ: Dynamic postural stability during sit-to-walk transitions in Parkinson disease patients. Mov. Disord.23(9),1274–1280 (2008).Crossref, MedlineGoogle Scholar
    • 53  Merello M, Fantacone N, Balej J: Kinematic study of whole body center of mass position during gait in Parkinson’s disease patients with and without festination. Mov. Disord.25(6),739–746 (2010).Crossref, MedlineGoogle Scholar
    • 54  Bleuse S, Cassim F, Blatt JL et al.: Anticipatory postural adjustments associated with arm movement in Parkinson’s disease: a biomechanical analysis. J. Neurol. Neurosurg. Psychiatry79(8),881–887 (2008).Crossref, Medline, CASGoogle Scholar
    • 55  Dimitrova D, Horak FB, Nutt JG: Postural muscle responses to multidirectional translations in patients with Parkinson’s disease. J. Neurophysiol.91(1),489–501 (2004).Crossref, MedlineGoogle Scholar
    • 56  Adkin AL, Frank JS, Jog MS: Fear of falling and postural control in Parkinson’s disease. Mov. Disord.18(5),496–502 (2003).Crossref, MedlineGoogle Scholar
    • 57  Ashburn A, Fazakarley L, Ballinger C, Pickering R, McLellan LD, Fitton C: A randomised controlled trial of a home based exercise programme to reduce the risk of falling among people with Parkinson’s disease. J. Neurol. Neurosurg. Psychiatry78(7),678–684 (2007).Crossref, MedlineGoogle Scholar
    • 58  Latt MD, Lord SR, Morris JG, Fung VS: Clinical and physiological assessments for elucidating falls risk in Parkinson’s disease. Mov. Disord.24(9),1280–1289 (2009).Crossref, MedlineGoogle Scholar
    • 59  Matinolli M, Korpelainen JT, Korpelainen R, Sotaniemi KA, Virranniemi M, Myllyla VV: Postural sway and falls in Parkinson’s disease: a regression approach. Mov. Disord.22(13),1927–1935 (2007).Crossref, MedlineGoogle Scholar
    • 60  Bloem BR, Grimbergen YA, Cramer M, Willemsen M, Zwinderman AH: Prospective assessment of falls in Parkinson’s disease. J. Neurol.248(11),950–958 (2001).Crossref, Medline, CASGoogle Scholar
    • 61  Fink HA, Kuskowski MA, Orwoll ES, Cauley JA, Ensrud KE; Osteoporotic Fractures in Men (MrOS) Study Group: Association between Parkinson’s disease and low bone density and falls in older men: the osteoporotic fractures in men study. J. Am. Geriatr. Soc.53(9),1559–1564 (2005).Crossref, MedlineGoogle Scholar
    • 62  Temlett JA, Thompson PD: Reasons for admission to hospital for Parkinson’s disease. Intern. Med. J.36(8),524–526 (2006).Crossref, Medline, CASGoogle Scholar
    • 63  Woodford H, Walker R: Emergency hospital admissions in idiopathic Parkinson’s disease. Mov. Disord.20(9),1104–1108 (2005).Crossref, MedlineGoogle Scholar
    • 64  Allcock LM, Rowan EN, Steen IN, Wesnes K, Kenny RA, Burn DJ: Impaired attention predicts falling in Parkinson’s disease. Parkinsonism Relat. Disord.15(2),110–115 (2009).Crossref, Medline, CASGoogle Scholar
    • 65  Ashburn A, Stack E, Ballinger C, Fazakarley L, Fitton C: The circumstances of falls among people with Parkinson’s disease and the use of falls diaries to facilitate reporting. Disabil. Rehabil.30(16),1205–1212 (2008).Crossref, Medline, CASGoogle Scholar
    • 66  Wood BH, Bilclough JA, Bowron A, Walker RW: Incidence and prediction of falls in Parkinson’s disease: a prospective multidisciplinary study. J. Neurol. Neurosurg. Psychiatry72(6),721–725 (2002).Crossref, Medline, CASGoogle Scholar
    • 67  Melton LJ III, Leibson CL, Achenbach SJ et al.: Fracture risk after the diagnosis of Parkinson’s disease: influence of concomitant dementia. Mov. Disord.21(9),1361–1367 (2006).Crossref, MedlineGoogle Scholar
    • 68  Rahman S, Griffin HJ, Quinn NP, Jahanshahi M: Quality of life in Parkinson’s disease: the relative importance of the symptoms. Mov. Disord.23(10),1428–1434 (2008).Crossref, MedlineGoogle Scholar
    • 69  Bacon WE: Secular trends in hip fracture occurrence and survival: age and sex differences. J. Aging Health8(4),538–553 (1996).Crossref, Medline, CASGoogle Scholar
    • 70  Kempster PA, O’Sullivan SS, Holton JL, Revesz T, Lees AJ: Relationships between age and late progression of Parkinson’s disease: a clinico-pathological study. Brain133(Pt 6),1755–1762 (2010).Crossref, MedlineGoogle Scholar
    • 71  Dennison AC, Noorigian JV, Robinson KM et al.: Falling in Parkinson disease: identifying and prioritizing risk factors in recurrent fallers. Am. J. Phys. Med. Rehabil.86(8),621–632 (2007).Crossref, MedlineGoogle Scholar
    • 72  Mak MK, Pang MY: Fear of falling is independently associated with recurrent falls in patients with Parkinson’s disease: a 1-year prospective study. J. Neurol.256(10),1689–1695 (2009).Crossref, MedlineGoogle Scholar
    • 73  Martignoni E, Tassorelli C, Nappi G: Cardiovascular dysautonomia as a cause of falls in Parkinson’s disease. Parkinsonism Relat. Disord.12(4),195–204 (2006).Crossref, MedlineGoogle Scholar
    • 74  Moore ST, MacDougall HG, Gracies JM et al.: Locomotor response to levodopa in fluctuating Parkinson’s disease. Exp. Brain Res.184(4),469–478 (2008).Crossref, MedlineGoogle Scholar
    • 75  Sethi K: Levodopa unresponsive symptoms in Parkinson disease. Mov. Disord.23(Suppl. 3),S521–S533 (2008).Crossref, MedlineGoogle Scholar
    • 76  Blin O, Fernandez AM, Pailhous J et al.: Dopa-sensitive and dopa-resistance gait parameters in Parkinson’s disease. J. Neurol. Sci.103(1),51–54 (1991).Crossref, Medline, CASGoogle Scholar
    • 77  Blin O, Fernandez AM, Serratrice G: Quantitative analysis of gait in Parkinson patients: increased variability of stride length. J. Neurol. Sci.98(1),91–97 (1990).Crossref, Medline, CASGoogle Scholar
    • 78  Bowes SG, Clark PK, Leeman AL et al.: Determinants of gait in the elderly parkinsonian on maintenance levodopa/carbidopa therapy. Br. J. Clin. Pharmacol.30(1),13–24 (1990).Crossref, Medline, CASGoogle Scholar
    • 79  Pedersen SW, Eriksson T, Oberg B: Effects of withdrawal of antiparkinson medication on gait and clinical score in the Parkinson patient. Acta Neurol. Scand.84(1),7–13 (1991).Crossref, Medline, CASGoogle Scholar
    • 80  McIntosh GC, Brown SH, Rice RR et al.: Rhythmic auditory-motor facilitation of gait patterns in patients with Parkinson’s disease. J. Neurol. Neurosurg. Psych.62(1),22–26 (1997).Crossref, Medline, CASGoogle Scholar
    • 81  Azulay JP, Mesure S, Amblard B et al.: Visual control of locomotion in Parkinson’s disease. Brain122(Pt 1),111–120 (1999).Crossref, MedlineGoogle Scholar
    • 82  Hanakawa T, Katsumi Y, Fukuyama H et al.: Enhanced lateral premotor activity during paradoxical gait in Parkinson’s disease. Ann. Neurol.45(3),329–336 (1999).Crossref, Medline, CASGoogle Scholar
    • 83  Ebersbach G, Sojer M, Valldeoriola F et al.: Comparative analysis of gait in Parkinson’s disease, cerebellar ataxia and subcortical arteriosclerotic encephalopathy. Brain122(Pt 7),1349–1355 (1999).Crossref, MedlineGoogle Scholar
    • 84  Morris ME, Matyas TA, Iansek R et al.: Temporal stability of gait in Parkinson’s disease. Phys. Ther.76(7),763–777 (1996).Crossref, Medline, CASGoogle Scholar
    • 85  Koozekanani SH, Balmaseda MT Jr, Fatehi MT et al.: Ground reaction forces during ambulation in parkinsonism: pilot study. Arch. Phys. Med. Rehabil.68(1),28–30 (1987).Crossref, Medline, CASGoogle Scholar
    • 86  O’Sullivan JD, Said CM, Dillon LC et al.: Gait analysis in patients with Parkinson’s disease and motor fluctuations: influence of levodopa and comparison with other measures of motor function. Mov. Disord.13(6),900–906 (1998).Crossref, MedlineGoogle Scholar
    • 87  Morris M, Iansek R, Matyas T et al.: Abnormalities in the stride length–cadence relation in parkinsonian gait. Mov. Disord.13(1),61–69 (1998).Crossref, Medline, CASGoogle Scholar
    • 88  Okuma Y.: Freezing of gait in Parkinson’s disease. J. Neurol.253(Suppl. 7),VII27–VII32 (2006).Crossref, MedlineGoogle Scholar
    • 89  Fahn S: The freezing phenomenon in parkinsonism. Adv. Neurol.67,53–63 (1995).Medline, CASGoogle Scholar
    • 90  Schaafsma JD, Balash Y, Gurevich T et al.: Characterization of freezing of gait subtypes and the response of each to levodopa in Parkinson’s disease. Eur. J. Neurol.10(4),391–398 (2003).Crossref, Medline, CASGoogle Scholar
    • 91  Giladi N: Freezing of gait. Clinical overview. Adv. Neurol.87,191–197 (2001).Medline, CASGoogle Scholar
    • 92  Giladi N: Medical treatment of freezing of gait. Mov. Disord.23(Suppl. 2),S482–S488 (2008).Crossref, MedlineGoogle Scholar
    • 93  Giladi N, McDermott MP, Fahn S et al.: Freezing of gait in PD: prospective assessment in the DATATOP cohort. Neurology56(12),1712–1721 (2001).Crossref, Medline, CASGoogle Scholar
    • 94  Shoulson I: DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl and tocopherol antioxidative therapy of parkinsonism. Ann. Neurol.44(3 Suppl. 1),S160–S166 (1998).Crossref, Medline, CASGoogle Scholar
    • 95  Shoulson I, Oakes D, Fahn S et al.: Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson’s disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial. Ann. Neurol.51(5),604–612 (2002).Crossref, Medline, CASGoogle Scholar
    • 96  Giladi N, Treves TA, Simon ES et al.: Freezing of gait in patients with advances Parkinson’s disease. J. Neural Trans.108(1),53–61 (2001).Crossref, Medline, CASGoogle Scholar
    • 97  Macht M, Kaussner Y, Moller JC et al.: Predictors of freezing in Parkinson’s disease: a survey of 6,620 patients. Mov. Disord.22(7),953–956 (2007).Crossref, MedlineGoogle Scholar
    • 98  Giladi N, Honigman S: Botulinum toxin injections to one leg alleviate freezing of gait in a patient with Parkinson’s disease. Mov. Disord.12(6),1085–1086 (1997).Crossref, Medline, CASGoogle Scholar
    • 99  Giladi N, Gurevich T, Shabtai H et al.: The effect of botulinum toxin injections to the calf muscles on freezing of gait in parkinsonism: a pilot study. J. Neurol.248(7),572–576 (2001).Crossref, Medline, CASGoogle Scholar
    • 100  Gurevich T, Peretz C, Moore O et al.: The effect of injecting botulinum toxin type a into the calf muscles on freezing of gait in Parkinson’s disease: a double blind placebo-controlled pilot study. Mov. Disord.22(6),880–883 (2007).Crossref, MedlineGoogle Scholar
    • 101  Pollak L, Dobronevsky Y, Prohorov T et al.: Low dose methylphenidate improves freezing in advanced parkinson’s disease during off-state. J. Neural Trans. Suppl.72,145–148 (2007).Crossref, CASGoogle Scholar
    • 102  Auriel E, Hausdorff JM, Herman T et al.: Effects of methylphenidate on cognitive function and gait in patients with Parkinson’s disease: a pilot study. Clin. Neuropharmacol.29(1),15–17 (2006).Crossref, Medline, CASGoogle Scholar
    • 103  Vaamonde Gamo J, Cabello JP, Gallardo Alcañiz MJ et al.: Freezing of gait unresponsive to dopaminergic stimulation in patients with severe parkinsonism. Neurologia25(1),27–31 (2010).Crossref, Medline, CASGoogle Scholar
    • 104  Clarke CE, Worth P, Grosset D et al.: Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson’s disease. Parkinsonism Relat. Disord.15(10),728–741 (2009).Crossref, MedlineGoogle Scholar
    • 105  Tagliati M: Fine-tuning gait in Parkinson disease. Neurology71(2),76–77 (2008).Crossref, MedlineGoogle Scholar
    • 106  Van Nuenen BF, Esselink RA, Munneke M et al.: Postoperative gait deterioration after bilateral subthalamic nucleus stimulation in Parkinson’s disease. Mov. Disord.23(16),2404–2406 (2008).Crossref, MedlineGoogle Scholar
    • 107  Krack P, Batir A, Blercom N et al.: Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N. Engl. J. Med.349(20),1925–1934 (2003).Crossref, Medline, CASGoogle Scholar
    • 108  Bakker M, Esselink RA, Munneke M et al.: Effects of stereotactic neurosurgery on postural instability and gait in Parkinson’s disease. Mov. Disord.19(9),1092–1099 (2004).Crossref, MedlineGoogle Scholar
    • 109  Johnsen EL, Mogensen PH, Sunde NA et al.: Improved asymmetry of gait in Parkinson’s disease with DBS: gait and postural instability in Parkinson’s disease treated with bilateral stimulation in the subthalamic nucleus. Mov. Disord.24(4),590–597 (2009).Crossref, MedlineGoogle Scholar
    • 110  Hausdorff JM, Gruendlinger L, Scollins L et al.: Deep brain stimulation effects on gait variability in Parkinson’s disease. Mov. Disord.24(11),1688–1692 (2009).Crossref, MedlineGoogle Scholar
    • 111  Volkmann J: Deep brain stimulation for the treatment of Parkinson’s disease. J. Clin. Neurophysiol.21(1),6–17 (2004).Crossref, MedlineGoogle Scholar
    • 112  Mazzone P, Lozano A, Stanzione P et al.: Implantation of human pedunculopontine nucleus: a safe and clinically relevant target in Parkinson’s disease. Neuroreport16(17),1877–1881 (2005).Crossref, MedlineGoogle Scholar
    • 113  Plaha P, Gill SS.: Bilateral deep brain stimulation of the pedunculopontine nucleus for Parkinson’s disease. Neuroreport16(17),1883–1887 (2005).Crossref, MedlineGoogle Scholar
    • 114  Moro E, Hamani C, Poon YY et al.: Unilateral pedunculopontine stimulation improves fall in Parkinson’s disease. Brain133(Pt 1),215–224 (2010).Crossref, MedlineGoogle Scholar
    • 115  Stefani A, Lozano AM, Peppe A et al.: Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson’s disease. Brain130(Pt 6),1596–1607 (2007).Crossref, MedlineGoogle Scholar
    • 116  Davis JT, Lyons KE, Pahwa R: Freezing of gait after bilateral subthalamic nucleus stimulation for Parkinson’s disease. Clin. Neurol. Neurosurg.108(5),461–464 (2006).Crossref, MedlineGoogle Scholar
    • 117  Limousin P, Krack P, Pollak P et al.: Electrical stimulation of the subthalamic nucleus in advanced Parkinson’s disease. N. Engl. J. Med.339(16),1105–1111 (1998).Crossref, Medline, CASGoogle Scholar
    • 118  Stolze H, Klebe S, Poepping M et al.: Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait. Neurology57(1),144–146 (2001).Crossref, Medline, CASGoogle Scholar
    • 119  Yokoyama T, Sugiyama K, Nishizawa S et al.: Subthalamic nucleus stimulation for gait disturbance in Parkinson’s disease. Neurosurgery45(1),41–47 (1999).Crossref, Medline, CASGoogle Scholar
    • 120  Rodriguez-Oroz MC, Obeso JA, Lang AE et al.: Bilateral deep brain stimulation in Parkinson’s disease: a multicentre study with 4 years follow-up. Brain128(Pt 10),2240–2249 (2005).Crossref, Medline, CASGoogle Scholar
    • 121  Bejjani BP, Gervais D, Arnulf I et al.: Axial parkinsonian symptoms can be improved: the role of levodopa and bilateral subthalamic stimulation. J. Neurol. Neurosurg. Psych.68(5),595–600 (2000)Crossref, Medline, CASGoogle Scholar
    • 122  Nandi D, Aziz TZ, Giladi N et al.: Reversal of akinesia in experimental parkinsonism by GABA antagonist microinjections in the pedunculopontine nucleus. Brain125(Pt 11),2418–2430 (2002).Crossref, MedlineGoogle Scholar
    • 123  Munro-Davies LE, Winter J, Aziz TZ et al.: The role of the pedunculopontine region in basal-ganglia mechanisms of akinesia. Exp. Brain Res.129(4),511–517 (1999).Crossref, Medline, CASGoogle Scholar
    • 124  Benedetti F, Pollo A, Lopiano L et al.: Conscioius expectation and unconscious conditioning in analgesic, motor, and hormonal placebo/nocebo responses. J. Neurosci.23(10),4315–4323 (2003).Crossref, Medline, CASGoogle Scholar
    • 125  Mehrholz J, Friis R, Kugler J et al.: Treadmill training for patients with Parkinson’s disease (review). Cochrane Database Syst. Rev. (1), 1–31 (2010).Google Scholar
    • 126  Fisher BE, Wu AD, Salem GJ et al.: The effect of exercise training in improving motor performance and corticomotor excitability in people with early Parkinson’s disease. Arch. Phys. Med. Rehabil.89(7),1221–1229 (2008).Crossref, MedlineGoogle Scholar
    • 127  Pohl M, Rockstroh G, Ruckriem S et al.: Immediate effects of speed-dependent treadmill training on gait parameters in early Parkinson’s disease. Arch. Phys. Med. Rehabil.84(12),1760–1766 (2003).Crossref, MedlineGoogle Scholar
    • 128  Miyai I, Fujimoto Y, Ueda Y et al.: Treadmill training with body weight support: its effect on Parkinson’s disease. Arch. Phys. Med. Rehabil.81(7),849–852 (2000).Crossref, Medline, CASGoogle Scholar
    • 129  Protas EJ, Mitchell K, Williams A et al.: Gait and step training to reduce falls in Parkinson’s disease. NeuroRehabilitation20(3),183–190 (2005).Crossref, MedlineGoogle Scholar
    • 130  Cakit BD, Saracoglu M, Genc H et al.: The effects of incremental speed-dependent treadmill training on postural instability and fear of falling in Parkinson’s disease. Clin. Rehabil.21(8),698–705 (2007).Crossref, MedlineGoogle Scholar
    • 131  Kurtais Y, Kutlay S, Tur BS et al.: Does treadmill training improve lower-extremity tasks in Parkinson disease? A randomized controlled trial. Clin. J. Sports Med.18(3),289–291 (2008).Crossref, MedlineGoogle Scholar
    • 132  Herman T, Giladi N, Gruendlinger L et al.: Six weeks of intensive treadmill training improves gait and quality of life in patients with Parkinson’s disease: a pilot study. Arch. Phys. Med. Rehabil.88(9),1154–1158 (2007).Crossref, MedlineGoogle Scholar
    • 133  Bello O, Marquez G, Camblor M et al.: Mechanisms involved in treadmill walking improvements in Parkinson’s disease. Gait Posture32,118–123 (2010).Crossref, MedlineGoogle Scholar
    • 134  Rubinstein TC, Giladi N, Hausdorff JM: The power of cueing to circumvent dopamine deficits: a review of physical therapy treatment of gait disturbances in Parkinson’s disease. Mov. Disord.17(6),1148–1160 (2002).Crossref, MedlineGoogle Scholar
    • 135  Murray MP, Sepic SB, Gardner GM et al.: Walking patterns of men with parkinsonism. Am. J. Phys. Med.57(6),278–294 (1978).Medline, CASGoogle Scholar
    • 136  Morris ME.: Movement disorders in people with Parkinson disease: a model for physical therapy. Phys. Ther.80(6),578–597 (2000).Crossref, Medline, CASGoogle Scholar
    • 137  Rochester L, Baker K, Hetherington V et al.: Evidence for motor learning in Parkinson’s disease: acquisition, automaticity and retention of cued gait performance after training with external rhythmical cues. Brain Res.1319,103–111 (2010).Crossref, Medline, CASGoogle Scholar
    • 138  Jiang Y, Norman KE: Effects of visual and auditory cues on gait initiation in people with Parkinson’s disease. Clin. Rehabil.20(1),36–45 (2006).Crossref, MedlineGoogle Scholar
    • 139  Rochester L, Burn DJ, Woods G, Godwin J, Nieuwboer A: Does auditory rhythmical cueing improve gait in people with Parkinson’s disease and cognitive impairment? A feasibility study. Mov. Disord.24(6),839–845 (2009).Crossref, MedlineGoogle Scholar
    • 140  Suteerawattananon M, Morris GS, Etnyre BR, Jankovic J, Protas EJ: Effects of visual and auditory cues on gait in individuals with Parkinson’s disease. J. Neurol. Sci.219(1–2),63–69 (2004).Crossref, Medline, CASGoogle Scholar
    • 141  Willems AM, Nieuwboer A, Chavret F et al.: Turning in Parkinson’s disease patients and controls: the effect of auditory cues. Mov. Disord.22(13),1871–1878 (2007).Crossref, MedlineGoogle Scholar
    • 142  Nieuwboer A, Baker K, Willems AM et al.: The short-term effects of different cueing modalities on turn speed in people with Parkinson’s disease. Neurorehabil. Neural Repair23(8),831–836 (2009).Crossref, MedlineGoogle Scholar
    • 143  Rochester L, Rafferty D, Dotchin C, Msuya O, Minde V, Walker RW: The effect of cueing therapy on single and dual-task gait in a drug naive population of people with Parkinson’s disease in northern Tanzania. Mov. Disord.25(7),906–911 (2010).Crossref, MedlineGoogle Scholar
    • 144  Mak MK, Hui-Chan CW: Cued task-specific training is better than exercise in improving sit-to-stand in patients with Parkinson’s disease: a randomized controlled trial. Mov. Disord.23(4),501–509 (2008).Crossref, MedlineGoogle Scholar
    • 145  Baker K, Rochester L, Nieuwboer A: The effect of cues on gait variability – reducing the attentional cost of walking in people with Parkinson’s disease. Parkinsonism Relat. Disord.14(4),314–320 (2008).Crossref, MedlineGoogle Scholar
    • 146  Baker K, Rochester L, Nieuwboer A: The immediate effect of attentional, auditory, and a combined cue strategy on gait during single and dual tasks in Parkinson’s disease. Arch. Phys. Med. Rehabil.88(12),1593–1600 (2007).Crossref, MedlineGoogle Scholar
    • 147  Nieuwboer A: Cueing for freezing of gait in patients with Parkinson’s disease: a rehabilitation perspective. Mov. Disord.23(Suppl. 2),S475–S481 (2008).Crossref, MedlineGoogle Scholar
    • 148  Bryant MS, Rintala DH, Lai EC, Protas EJ: An evaluation of self-administration of auditory cueing to improve gait in people with Parkinson’s disease. Clin. Rehabil.23(12),1078–1085 (2009).Crossref, Medline, CASGoogle Scholar
    • 149  Morris ME, Martin CL, Schenkman ML: Striding out with Parkinson disease: evidence-based physical therapy for gait disorders. Phys. Ther.90(2),280–288 (2010).• Review of current evidence to support specific physical therapy approaches to management of gait in PD.Crossref, MedlineGoogle Scholar
    • 150  Satoh M, Kuzuhara S: Training in mental singing while walking improves gait disturbance in Parkinson’s disease patients. Eur. Neurol.60(5),237–243 (2008).Crossref, MedlineGoogle Scholar
    • 151  Ford MP, Malone LA, Nyikos I, Yelisetty R, Bickel CS: Gait training with progressive external auditory cueing in persons with Parkinson’s disease. Arch. Phys. Med. Rehabil.91(8),1255–1261 (2010).Crossref, MedlineGoogle Scholar
    • 152  Nieuwboer A, Kwakkel G, Rochester L et al.: Cueing training in the home improves gait-related mobility in Parkinson’s disease: the RESCUE trial. J. Neurol. Neurosurg. Psychiatry78(2),134–140 (2007).Crossref, Medline, CASGoogle Scholar
    • 153  Bryant MS, Rintala DH, Lai EC et al.: Evaluation of a new device to prevent falls in persons with Parkinson’s disease. Disabil. Rehabil. Assist. Technol.4(5),357–363 (2010).CrossrefGoogle Scholar
    • 154  Cubo E, Moore CG, Leugran S et al.: Wheeled and standard walkers in Parkinson’s disease patients with gait freezing. Parkinsonism Relat. Disord.10(1),9–14 (2003).Crossref, MedlineGoogle Scholar
    • 155  Constantinescu R, Leonard C, Deeley C et al.: Assistive devices for gait in Parkinson’s disease. Parkinsonism Relat. Disord.13(3),133–138 (2007).Crossref, MedlineGoogle Scholar
    • 156  Bächlin M, Plotnik M, Roggen D et al.: A wearable system to assist walking of Parkinson s disease patients. Methods Inf. Med.49(1),88–95 (2010).Crossref, Medline, CASGoogle Scholar
    • 157  Cano-de-la-Cuerda R, Perez-de-Heredia M, Miangolarra-Page JC et al.: Is there muscular weakness in Parkinson’s disease? Am. J. Phys. Med. Rehabil.89(1),70–76 (2010).Crossref, MedlineGoogle Scholar
    • 158  Koller W, Kase S: Muscle strength testing in Parkinson’s disease. Eur. Neurol.25(2),130–133 (1986).Crossref, Medline, CASGoogle Scholar
    • 159  Macaluso A, De Vito G: Muscle strength, power and adaptations to resistance training in older people. Eur. J. Appl. Physiol.91(4),450–472 (2004).Crossref, MedlineGoogle Scholar
    • 160  Falvo MJ, Schilling BK, Earhart GM: Parkinson’s disease and resistive exercise: rationale, review and recommendations. Mov. Disord.23(1),1–11 (2008).Crossref, MedlineGoogle Scholar
    • 161  Dibble LE, Hale TF, Marcus RL et al.: High intensity eccentric resistance training decreases bradykinesia and improves quality of life in persons with Parkinson’s disease: a preliminary study. Parkinsonism Relat. Disord.15(10),752–757 (2009).Crossref, MedlineGoogle Scholar
    • 162  Dibble LE, Hale TF, Marcus RL et al.: High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson’s disease. Mov. Disord.21(9),1444–1452 (2006).Crossref, MedlineGoogle Scholar
    • 163  Scandalis TA, Bosak A, Berliner JC et al.: Resistance training and gait function in patients with Parkinson’s disease. Am. J. Phys. Med. Rehabil.80(1),38–43 (2001).Crossref, Medline, CASGoogle Scholar
    • 164  Hirsch MA, Toole T, Matiland CG et al.: The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson’s disease. Arch. Phys. Med. Rehabil.84(8),1109–1117 (2003).Crossref, MedlineGoogle Scholar
    • 165  Toole T, Hirsch MA, Forkink A et al.: The effects of a balance and strength training program on equilibrium in parkinsonism: a preliminary study. NeuroRehabilitation14(3),165–174 (2000).Crossref, MedlineGoogle Scholar
    • 166  Dibble LE, Addison O, Papa E: The effects of exercise on balance in persons with Parkinson’s disease: a systematic review across the disability spectrum. J. Neurologic Phys. Ther.33(1),14–26 (2009).•• Systematic review of the latest evidence on balance training in PD.Crossref, MedlineGoogle Scholar
    • 167  Keus SH, Bloem BR, Hendriks EJ, Bredero-Cohen AB, Munneke M; Practice Recommendations Development Group: Evidence-based analysis of physical therapy in Parkinson’s disease with recommendations for practice and research. Mov. Disord.22(4),451–460; quiz 600 (2007).•• Establishes evidence-based guidelines for physical therapy practice in PD.Crossref, MedlineGoogle Scholar
    • 168  Canning CG, Sherrington C, Lord SR et al.: Exercise therapy for prevention of falls in people with Parkinson’s disease: a protocol for a randomised controlled trial and economic evaluation. BMC Neurol.9,4 (2009).Crossref, MedlineGoogle Scholar
    • 169  Frazzitta G, Maestri R, Bertotti G et al.: Rehabilitation in Parkinson’s disease: assessing the outcome using objective metabolic measurements. Mov. Disord.25(5),609–614 (2010).Crossref, MedlineGoogle Scholar
    • 170  King LA, Horak FB: Delaying mobility disability in people with Parkinson disease using a sensorimotor agility exercise program. Phys. Ther.89(4),384–393 (2009).Crossref, MedlineGoogle Scholar
    • 171  Tamir R, Dickstein R, Huberman M: Integration of motor imagery and physical practice in group treatment applied to subjects with Parkinson’s disease. Neurorehabil. Neural Repair21(1),68–75 (2007).Crossref, MedlineGoogle Scholar
    • 172  Gobbi LTB, Oliveira-Ferreira MDT, Caetano MJD et al.: Exercise programs improve mobility and balance in people with Parkinson’s disease. Parkinsonism Relat. Disord.15(Suppl. 3),S49–S52 (2009).Crossref, MedlineGoogle Scholar
    • 173  Jessop RT, Horowicz C, Dibble LE: Motor learning and Parkinson disease: Refinement of movement velocity and endpoint excursion in a limits of stability balance task. Neurorehabil. Neural Repair20(4),459–467 (2006).Crossref, MedlineGoogle Scholar
    • 174  Arias P, Chouza M, Vivas J, Cudeiro J: Effect of whole body vibration in Parkinson’s disease: a controlled study. Mov. Disord.24(6),891–898 (2009).Crossref, MedlineGoogle Scholar
    • 175  Ebersbach G, Edler D, Kaufhold O, Wissel J: Whole body vibration versus conventional physiotherapy to improve balance and gait in Parkinson’s disease. Arch. Phys. Med. Rehabil.89(3),399–403 (2008).Crossref, MedlineGoogle Scholar
    • 176  Rossi-Izquierdo M, Soto-Varela A, Santos-Perez S et al.: Vestibular rehabilitation with computerised dynamic posturography in patients with Parkinson’s disease: improving balance impairment. Disabil. Rehabil.31(23),1907–1916 (2009).Crossref, MedlineGoogle Scholar
    • 177  Zeigelboim BS, Klagenberg KF, Teive HA, Munhoz RP, Martins-Bassetto J: Vestibular rehabilitation: clinical benefits to patients with Parkinson’s disease. Arq. Neuropsiquiatr.67(2A),219–223 (2009).Crossref, MedlineGoogle Scholar
    • 178  Winogrodzka A, Wagenaar RC, Booij J, Wolters EC: Rigidity and bradykinesia reduce interlimb coordination in Parkinsonian gait. Arch. Phys. Med. Rehabil.86(2),183–189 (2005).Crossref, MedlineGoogle Scholar
    • 179  Wright WG, Gurfinkel VS, Nutt J, Horak FB, Cordo PJ: Axial hypertonicity in Parkinson’s disease: direct measurements of trunk and hip torque. Exp. Neurol.208(1),38–46 (2007).Crossref, Medline, CASGoogle Scholar
    • 180  Schenkman M, Cutson TM, Kuchibhatla M et al.: Exercise to improve spinal flexibility and function for people with Parkinson’s disease: a randomized, controlled trial. J. Am. Geriatr. Soc.46(10),1207–1216 (1998).Crossref, Medline, CASGoogle Scholar
    • 181  Schenkman M, Morey M, Kuchibhatla M: Spinal flexibility and balance control among community-dwelling adults with and without Parkinson’s disease. J. Gerontol. A Biol. Sci. Med. Sci.55(8),M441–M445 (2000).Crossref, Medline, CASGoogle Scholar
    • 182  Franzén E, Paquette C, Gurfinkel VS, Cordo PJ, Nutt JG, Horak FB: Reduced performance in balance, walking and turning tasks is associated with increased neck tone in Parkinson’s disease. Exp. Neurol.219(2),430–438 (2009).Crossref, MedlineGoogle Scholar
    • 183  Bartolo M, Serrao M, Tassorelli C et al.: Four-week trunk-specific rehabilitation treatment improves lateral trunk flexion in Parkinson’s disease. Mov. Disord.25(3),325–331 (2010).Crossref, MedlineGoogle Scholar
    • 184  Palo-Bengtsson L, Ekman SL: Social dancing in the care of persons with dementia in a nursing home setting: a phenomenological study. Sch. Inq. Nurs. Pract.11(2),101–108 (1997).Medline, CASGoogle Scholar
    • 185  Belardinelli R, Lacalaprice F, Ventrella C, Volpe L, Faccenda E: Waltz dancing in patients with chronic heart failure: a new form of exercise training. Circ. Heart Fail.1,107–114 (2008).Crossref, MedlineGoogle Scholar
    • 186  Peidro RM et al.: Tango: modificaciones cardiorrespiratorias durante el baile. Revista Argentina de Cardiologia70,358–363 (2002).Google Scholar
    • 187  Hackney ME, Kantorovich S, Levin R et al.: Effects of tango on functional mobility in Parkinson disease: a preliminary study. J. Neurol. Phys. Ther.31(4),173–179 (2007).Crossref, MedlineGoogle Scholar
    • 188  Hackney ME, Earhart GM: Short duration, intensive tango dancing for Parkinson disease: an uncontrolled pilot study. Complement. Ther. Med.17,203–207 (2009).Crossref, MedlineGoogle Scholar
    • 189  Hackney ME, Earhart GM: Effects of dance on movement control in Parkinson disease: a comparison of argentine tango and American Ballroom. J. Rehab. Med.41,475–481 (2009).Crossref, MedlineGoogle Scholar
    • 190  Hackney ME, Earhart GM: Effects of dance on gait and balance in Parkinson disease: a comparison of partnered and non-partnered dance movement. Neurorehabil. Neural Repair24(4),384–392 (2010).Crossref, MedlineGoogle Scholar
    • 191  Hackney ME, Earhart GM: Effects of dance on balance and gait in severe Parkinson disease: a case study. Disabil. Rehab.32(8),679–684 (2010).Crossref, MedlineGoogle Scholar
    • 192  Earhart GM: Dance as therapy for individuals with Parkinson disease. Eur. J. Phys. Med. Rehabil.45(2),231–238 (2009).Medline, CASGoogle Scholar
    • 193  Hackney ME, Earhart GM: Recommendations for implementing partnered tango classes for persons with Parkinson disease. Am. J. Dance Ther.32(1),41 (2010).Crossref, MedlineGoogle Scholar
    • 194  Lee MS, Lam P, Ernst E: Effectiveness of Tai Chi for Parkinson’s disease: a critical review. Parkinsonism Relat. Disord.14,589–594 (2008).Crossref, MedlineGoogle Scholar
    • 195  Marjama-Lyons J, Lamb P, Ernst E: Tai Chi and reduced rate of falling in Parkinson’s disease: a single blinded pilot study. Mov. Disord.17,S70–S71 (2002).Crossref, MedlineGoogle Scholar
    • 196  Hackney ME, Earhart GM: Tai Chi improves balance and mobility in people with Parkinson disease. Gait Posture28,456–460 (2008).Crossref, MedlineGoogle Scholar
    • 197  Cheon SM, Sung HR, Ha MS et al.: Tai Chi for physical and mental health of patients with Parkinson’s disease. In: Proceedings of the First International Conference of Tai Chi for Health. Seoul, Republic of Korea, 68 (abstract) (2006).Google Scholar
    • 198  van der Marck MA, Kalf JG, Sturkenboom IH, Nijkrake MJ, Munneke M, Bloem BR: Multidisciplinary care for patients with Parkinson’s disease. Parkinsonism Relat. Disord.15(Suppl. 3),S219–S223 (2009).Crossref, MedlineGoogle Scholar
    • 199  Cohen DB, Oh MY, Baser SM et al.: Fast-track programming and rehabilitation model: a novel approach to postoperative deep brain stimulation patient care. Arch. Phys. Med. Rehabil.88(10),1320–1324 (2007).Crossref, MedlineGoogle Scholar
    • 200  Ellis T, Katz DI, White DK, DePiero TJ, Hohler AD, Saint-Hilaire M: Effectiveness of an inpatient multidisciplinary rehabilitation program for people with Parkinson disease. Phys. Ther.88(7),812–819 (2008).• Presents the effects of a multidisciplinary inpatient program in a large sample of people with PD.Crossref, MedlineGoogle Scholar
    • 201  Ellis T, de Goede CJ, Feldman RG et al.: Efficacy of a physical therapy program in patients with Parkinson’s disease: a randomized controlled trial. Arch. Phys. Med. Rehabil.86(4),626–632 (2005).Crossref, MedlineGoogle Scholar
    • 202  Trend P, Kaye J, Gage H et al.: Short-term effectiveness of intensive multidisciplinary rehabilitation for people with Parkinson’s disease and their carers. Clin. Rehabil.16(7),717–725 (2002).Crossref, MedlineGoogle Scholar
    • 203  Carne W, Cifu DX, Marcinko P et al.: Efficacy of multidisciplinary treatment program on long-term outcomes of individuals with Parkinson’s disease. J. Rehabil. Res. Dev.42(6),779–786 (2005).Crossref, MedlineGoogle Scholar